Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

dermokine,  sk89,  1110014F24Rik,  sk30,  Dmkn,  cI-36

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Dmkn mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Dmkn by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Palmoplantar Keratoderma, Nonepidermolytic, Focal Or Diffuse
Palmoplantar keratoderma, Epidermal acanthosis OMIM:615735
Keratosis Palmoplantaris Striata Ii
Palmoplantar keratoderma, Epidermal acanthosis OMIM:612908
Peeling Skin Syndrome 5
Epidermal acanthosis, Hyperkeratosis OMIM:617115
Epidermolysis Bullosa Simplex 4, Localized Or Generalized Intermediate, Autosomal Recessive
Epidermal acanthosis, Hyperkeratosis OMIM:615028
Cole Disease
Epidermal acanthosis, Palmoplantar keratoderma, Hyperkeratosis OMIM:615522
Ichthyosis, Congenital, Autosomal Recessive 14
Scaling skin, Orthokeratotic hyperkeratosis, Erythema, Hyperkeratosis OMIM:617571
Acrokeratosis Verruciformis
Epidermal acanthosis, Hyperkeratosis OMIM:101900
Palmoplantar Keratoderma, Nagashima Type
Orthokeratotic hyperkeratosis, Epidermal acanthosis OMIM:615598
Erythrokeratodermia Variabilis Et Progressiva 4
Epidermal acanthosis, Erythema, Palmoplantar hyperkeratosis, Hyperkeratosis OMIM:617526
Psoriasis 2
Hyperkeratosis, Epidermal acanthosis, Scaling skin, Parakeratosis OMIM:602723
Erythrokeratodermia Variabilis Et Progressiva 3
Epidermal acanthosis, Palmoplantar keratoderma, Erythema, Hyperkeratosis OMIM:617525
Keratosis, Focal Palmoplantar And Gingival
Circumungual hyperkeratosis, Focal friction-related palmoplantar hyperkeratosis, Gingival hyperke... OMIM:148730
Peeling Skin Syndrome 4
Palmoplantar keratoderma, Orthokeratosis, Hyperkeratosis, Scaling skin, Epidermal acanthosis OMIM:607936
Palmoplantar Keratoderma, Nonepidermolytic, Focal 2
Palmoplantar keratoderma, Hyperkeratosis OMIM:616400
Epidermolytic Hyperkeratosis
Scaling skin, Palmoplantar hyperkeratosis, Epidermal acanthosis OMIM:113800
Hereditary Palmoplantar Keratoderma, Gamborg-Nielsen Type
Diffuse palmoplantar hyperkeratosis, Hyperkeratosis with erythema ORPHA:86923
Verrucous Hemangioma
Hyperkeratotic papule, Epidermal acanthosis ORPHA:464318
Infantile Digital Fibromatosis
Hyperkeratosis, Epidermal acanthosis, Parakeratosis ORPHA:199267
Erythrokeratodermia Variabilis Et Progressiva 5
Palmoplantar hyperkeratosis, Hyperkeratosis OMIM:617756
Peeling Skin With Leukonychia, Acral Punctate Keratoses, Cheilitis, And Knuckle Pads
Scaling skin, Epidermal acanthosis, Palmoplantar keratoderma, Hyperkeratosis OMIM:616295
Krt1-Related Diffuse Nonepidermolytic Keratoderma
Dry skin, Erythema, Scaling skin, Nonepidermolytic palmoplantar hyperkeratosis, Palmoplantar scal... ORPHA:530838
White Sponge Nevus 2
Hyperparakeratosis, Epidermal acanthosis OMIM:615785
Hyperkeratosis Lenticularis Perstans
Hyperkeratosis lenticularis perstans OMIM:144150
Angioma Serpiginosum, Autosomal Dominant
Hyperkeratosis OMIM:106050
Reticulate Acropigmentation Of Kitamura
Hyperkeratosis OMIM:615537
Papillomatosis, Confluent And Reticulated
Hyperkeratosis OMIM:167900
Epidermolysis Bullosa Simplex 1C, Localized
Hyperkeratosis OMIM:131800
Mental Retardation, Fra12A Type
Hyperkeratosis OMIM:136630
Palmoplantar Keratoderma-Deafness Syndrome
Palmoplantar keratoderma, Hyperkeratosis ORPHA:2202
Palmoplantar Keratoderma, Norrbotten Recessive Type
Palmoplantar keratoderma, Hyperkeratosis OMIM:244850
Palmoplantar Keratoderma, Punctate Type Iii
Hyperkeratosis OMIM:101850
Palmoplantar Keratoderma, Punctate Type Ia
Punctate palmoplantar hyperkeratosis, Orthokeratosis, Epidermal acanthosis OMIM:148600
Sjogren-Larsson-Like Ichthyosis Without Cns Or Eye Involvement
Hyperkeratosis OMIM:270220
Hyperkeratosis ORPHA:1659
Ichthyosis, Congenital, Autosomal Recessive 6
Dry skin, Palmoplantar keratoderma, Parakeratosis, Orthokeratosis, Hyperkeratosis, Scaling skin, ... OMIM:612281
Ichthyosis, Congenital, Autosomal Recessive 13
Palmoplantar hyperkeratosis, Hyperkeratosis OMIM:617574
Peeling Skin Syndrome 2
Scaling skin, Erythema OMIM:609796
Ichthyosis-Alopecia-Eclabion-Ectropion-Intellectual Disability Syndrome
Dry skin, Cutis laxa, Scaling skin, Generalized hyperkeratosis, Epidermal acanthosis ORPHA:2269
Hypotrichosis Simplex Of The Scalp
Hyperkeratosis, Epidermal acanthosis, Scaling skin, Parakeratosis ORPHA:90368
Erythrokeratodermia Variabilis Et Progressiva 1
Generalized hyperkeratosis, Patchy palmoplantar hyperkeratosis, Epidermal acanthosis OMIM:133200
Dowling-Degos Disease 2
Hyperkeratotic papule, Follicular hyperkeratosis OMIM:615327
Keratoderma Hereditarium Mutilans With Ichthyosis
Palmoplantar keratoderma, Parakeratosis, Orthokeratosis, Honeycomb palmoplantar hyperkeratosis, H... ORPHA:79395
Ichthyosis, Congenital, Autosomal Recessive 12
White scaling skin OMIM:617320
Peeling Skin Syndrome 3
White scaling skin OMIM:616265
Ichthyosis, Lamellar, Autosomal Dominant
Hyperkeratosis OMIM:146750
Olmsted Syndrome, X-Linked
Subungual hyperkeratosis, Palmoplantar keratoderma, Parakeratosis, Hyperkeratosis, Palmoplantar h... OMIM:300918
Congenital Panfollicular Nevus
Hyperkeratosis ORPHA:139414
Ectodermal Dysplasia/Skin Fragility Syndrome
Scaling skin, Palmoplantar hyperkeratosis OMIM:604536
Dowling-Degos Disease 4
Epidermal acanthosis OMIM:615696
Familial Reactive Perforating Collagenosis
Hyperkeratotic papule, Abnormal epidermal morphology ORPHA:79147
Epidermolytic Palmoplantar Keratoderma
Epidermal hyperkeratosis, Palmoplantar hyperkeratosis, Palmar hyperkeratosis, Diffuse palmoplanta... ORPHA:2199
Bazex Syndrome
Hyperkeratosis, Palmoplantar keratoderma, Scaling skin, Parakeratosis ORPHA:166113
Ichthyosis, Congenital, Autosomal Recessive 8
Epidermal acanthosis, Orthokeratosis, Erythema, Hyperkeratosis OMIM:613943
Elastosis Perforans Serpiginosa
Hyperkeratotic papule, Cutis laxa, Epidermal acanthosis ORPHA:79148
Atrophoderma Vermiculata
Hyperkeratotic papule, Follicular hyperkeratosis, Erythema, Abnormal epidermal morphology ORPHA:79100
Ichthyosis, Congenital, Autosomal Recessive 9
Epidermal acanthosis OMIM:615023
Hyperkeratosis-Hyperpigmentation Syndrome
Hyperkeratosis ORPHA:1336
Pachyonychia Congenita 4
Palmoplantar keratoderma, Hyperkeratosis OMIM:615728
Amyloidosis, Primary Localized Cutaneous, 1
Scaling skin, Dry skin, Cutis laxa OMIM:105250
Ichthyosis, Spastic Quadriplegia, And Mental Retardation
Dry skin, Erythema, Scaling skin, Hyperkeratosis OMIM:614457
Palmoplantar Keratoderma I, Striate, Focal, Or Diffuse
Orthokeratotic hyperkeratosis, Palmoplantar keratoderma, Streaks of hyperkeratosis along each fin... OMIM:148700
Erythrokeratoderma ''En Cocardes''
Hyperkeratosis ORPHA:315
Familial Benign Chronic Pemphigus
Erythema, Acantholysis, Skin vesicle, Hyperkeratosis ORPHA:2841
Bathing Suit Ichthyosis
Scaling skin, Epidermal acanthosis, Palmoplantar hyperkeratosis, Parakeratosis ORPHA:100976
Acral Self-Healing Collodion Baby
Palmoplantar scaling skin, Erythema, Lack of skin elasticity ORPHA:281127
Congenital Disorder Of Glycosylation, Type If
Dry skin, Scaling skin, Hyperkeratosis OMIM:609180
Ectodermal Dysplasia/Short Stature Syndrome
Epidermal acanthosis, Hyperkeratosis OMIM:616029
Mal De Meleda
Epidermal acanthosis, Palmoplantar keratoderma, Erythema, Nonepidermolytic palmoplantar hyperkera... ORPHA:87503
Porokeratosis Of Mibelli
Hyperkeratosis ORPHA:735
Ichthyosis, Congenital, Autosomal Recessive 7
Palmoplantar keratoderma, Epidermal acanthosis OMIM:615022
Acral Peeling Skin Syndrome
Scaling skin, Excessive wrinkling of palmar skin, Erythema ORPHA:263534
Ichthyosis, Congenital, Autosomal Recessive 5
Orthokeratosis, Palmoplantar keratoderma, Epidermal acanthosis, Parakeratosis OMIM:604777
Olmsted Syndrome 2
Palmoplantar keratoderma, Parakeratosis, Perioral hyperkeratosis, Hyperkeratosis, Palmoplantar hy... OMIM:619208
Acrokeratoelastoidosis Of Costa
Hyperkeratotic papule, Orthokeratosis, Palmoplantar hyperkeratosis, Epidermal acanthosis ORPHA:38
Epidermolysis Bullosa Dystrophica, Pretibial
Hyperkeratosis OMIM:131850
Glycogen Storage Disease Due To Lactate Dehydrogenase M-Subunit Deficiency
Scaling skin, Psoriasiform lesion, Parakeratosis ORPHA:284426
Infantile Cataract, Skin Abnormalities, Glutamate Excess, And Impaired Intellectual Development
Hyperkeratosis OMIM:618339
Acrokeratosis Verruciformis Of Hopf
Punctate palmoplantar hyperkeratosis, Epidermal acanthosis, Hyperkeratosis ORPHA:79151
Idiopathic Localized Lipodystrophy
Scaling skin, Erythema ORPHA:90158
Palmoplantar Keratoderma And Congenital Alopecia 2
Dry skin, Palmoplantar hyperkeratosis, Facial erythema, Hyperkeratosis OMIM:212360
Vulvovaginal Gingival Syndrome
Epidermal acanthosis, Erythema, Parakeratosis ORPHA:83453
Peeling Skin Syndrome 1
Scaling skin, Erythema OMIM:270300
Vohwinkel Syndrome, Variant Form
Hyperkeratosis, Orthokeratosis, Parakeratosis OMIM:604117
Aicardi-Goutieres Syndrome 5
Dry skin, Scaling skin OMIM:612952
Pemphigus Foliaceus
Scaling skin, Erythema, Acantholysis, Skin vesicle ORPHA:79481
Scaling skin, Dry skin OMIM:257960
Superficial Epidermolytic Ichthyosis
Palmoplantar keratoderma, Acantholysis, Erythema ORPHA:455
Ichthyosis Hystrix Of Curth-Macklin
Diffuse palmoplantar hyperkeratosis, Hyperkeratosis ORPHA:79503
Angioma Serpiginosum, X-Linked
Hyperkeratosis OMIM:300652
Singleton-Merten Syndrome 2
Hyperkeratosis OMIM:616298
Ichthyosis Vulgaris
Dry skin, Absent keratohyalin granules OMIM:146700
Basan Syndrome
Palmoplantar keratoderma, Epidermal acanthosis OMIM:129200
Porokeratosis 7, Multiple Types
Parakeratosis OMIM:614714
Recessive X-Linked Ichthyosis
Dry skin, Hyperkeratosis ORPHA:461
Huriez Syndrome
Congenital palmoplantar hyperkeratosis, Epidermal acanthosis OMIM:181600
Acquired Ichthyosis
Dry skin, Palmoplantar keratoderma, Erythema, Hyperkeratosis ORPHA:454
Tylosis With Esophageal Cancer
Diffuse palmoplantar hyperkeratosis, Parakeratosis OMIM:148500
Ichthyosis, Congenital, Autosomal Recessive 3
Palmoplantar keratoderma, Erythema, Hyperkeratosis OMIM:606545
Peeling Skin Syndrome 6
Orthokeratosis, Parakeratosis OMIM:618084
Ichthyosis With Confetti
Palmoplantar hyperkeratosis, Hyperkeratosis OMIM:609165
Hyperkeratosis Lenticularis Perstans
Hyperkeratosis lenticularis perstans, Skin ulcer ORPHA:409
Centrifugal Lipodystrophy
Scaling skin, Erythema ORPHA:90156
Hypotrichosis And Recurrent Skin Vesicles
Follicular hyperkeratosis, Epidermal acanthosis, Skin vesicle OMIM:613102
Palmoplantar Carcinoma, Multiple Self-Healing
Follicular hyperkeratosis, Palmoplantar keratoderma, Epidermal acanthosis, Parakeratosis OMIM:615225
Ichthyosis, Congenital, Autosomal Recessive 1
Epidermal acanthosis, Palmoplantar hyperkeratosis, Parakeratosis OMIM:242300
Seborrhea-Like Dermatitis With Psoriasiform Elements
Hyperkeratosis OMIM:610227
Cutaneous Mastocytoma
Scaling skin, Erythema ORPHA:79455
Irida Syndrome
Pallor, Hyperkeratosis ORPHA:209981
Pityriasis Rubra Pilaris
Orthokeratosis, Palmoplantar keratoderma, Subungual hyperkeratosis, Parakeratosis OMIM:173200
Pachyonychia Congenita 1
Follicular hyperkeratosis, Palmoplantar hyperkeratosis OMIM:167200
Ifap Syndrome 1, With Or Without Bresheck Syndrome
Dry skin, Follicular hyperkeratosis, Scaling skin OMIM:308205
Proteus Syndrome
Epidermal acanthosis, Hyperkeratosis OMIM:176920
Autosomal Dominant Epidermolytic Ichthyosis
Palmoplantar keratoderma, Skin ulcer, Hyperkeratosis ORPHA:312
Ichthyosis, Congenital, Autosomal Recessive 2
Epidermal acanthosis, Palmoplantar keratoderma, Erythema, Hyperkeratosis OMIM:242100
Ichthyosis Prematurity Syndrome
Follicular hyperkeratosis, Epidermal acanthosis OMIM:608649
Porokeratosis 3, Multiple Types
Parakeratosis OMIM:175900
Epidermodysplasia Verruciformis, Susceptibility To, 3
Epidermal acanthosis OMIM:618267
Ichthyosis, Leukocyte Vacuoles, Alopecia, And Sclerosing Cholangitis
Dry skin, Epidermal acanthosis, Orthokeratosis, Parakeratosis OMIM:607626
Lichen Planus Pemphigoides
Skin vesicle, Hyperkeratosis ORPHA:254478
Lymphatic Malformation 4
Hyperkeratosis OMIM:615907
Familial Keratoacanthoma
Skin ulcer, Hyperkeratosis ORPHA:493
Psoriasis 14, Pustular
Epidermal acanthosis, Erythema, Parakeratosis OMIM:614204
Autosomal Dominant Palmoplantar Keratoderma And Congenital Alopecia
Dry skin, Palmoplantar keratoderma, Scaling skin, Facial erythema ORPHA:1010
Gonadal Dysgenesis, Dysmorphic Facies, Retinal Dystrophy, And Myopathy
Dry skin, Scaling skin OMIM:618419
Pemphigus Vulgaris
Acantholysis ORPHA:704
Scaling skin ORPHA:79323
Skin Fragility-Woolly Hair Syndrome
Palmoplantar keratosis with erythema and scale, Acantholysis OMIM:607655
Punctate Palmoplantar Keratoderma Type 1
Hyperkeratotic papule, Palmoplantar keratoderma, Abnormal epidermal morphology, Orthokeratosis, P... ORPHA:79501
Diffuse Cutaneous Mastocytosis
Scaling skin ORPHA:79456
Autoinflammation With Arthritis And Dyskeratosis
Dry skin, Follicular hyperkeratosis, Palmoplantar hyperkeratosis, Epidermal acanthosis OMIM:617388
Rare Cutaneous Lupus Erythematosus
Scaling skin, Follicular hyperkeratosis, Erythema, Psoriasiform lesion ORPHA:535
Kid Syndrome
Scaling skin, Follicular hyperkeratosis, Palmoplantar keratoderma, Epidermal acanthosis ORPHA:477
Ectodermal Dysplasia-Skin Fragility Syndrome
Scaling skin, Follicular hyperkeratosis, Palmoplantar keratoderma ORPHA:158668
X-Linked Dominant Chondrodysplasia Punctata
Scaling skin ORPHA:35173
Inflammatory Skin And Bowel Disease, Neonatal, 2
Epidermal acanthosis OMIM:616069
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity
Scaling skin OMIM:606367
Odontoonychodermal Dysplasia
Erythema, Orthokeratosis, Dry skin, Plantar hyperkeratosis, Epidermal acanthosis OMIM:257980
Darier-White Disease
Subungual hyperkeratotic fragments, Acantholysis OMIM:124200
Erythroderma, Congenital, With Palmoplantar Keratoderma, Hypotrichosis, And Hyper-Ige
Orthokeratosis, Palmoplantar keratoderma, Acantholysis OMIM:615508
Mednik Syndrome
Hyperkeratosis ORPHA:171851
Hyperkeratosis ORPHA:79358
Immunodeficiency 58
Scaling skin, Psoriasiform lesion OMIM:618131
Bacterial Toxic-Shock Syndrome
Ecchymosis, Scaling skin ORPHA:36234
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Psoriasiform lesion ORPHA:169154
Graft Versus Host Disease
Scaling skin ORPHA:39812
Focal Facial Dermal Dysplasia Type Iv
Abnormal epidermal morphology ORPHA:398189
Porphyria Cutanea Tarda
Scaling skin ORPHA:101330
Immunodeficiency, Common Variable, 8, With Autoimmunity
Psoriasiform lesion OMIM:614700
Restrictive Dermopathy
Epidermal hyperkeratosis, Generalized hyperkeratosis, Dermal translucency, Scaling skin ORPHA:1662
Riddle Syndrome
Scaling skin, Erythema ORPHA:420741
Neonatal Inflammatory Skin And Bowel Disease
Scaling skin, Erythema ORPHA:294023
Pemphigus Erythematosus
Acantholysis ORPHA:79480
Osteomyelitis, Sterile Multifocal, With Periostitis And Pustulosis
Epidermal acanthosis, Hyperkeratosis OMIM:612852
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Dry skin, Scaling skin, Skin ulcer ORPHA:2526
Naxos Disease
Palmoplantar keratoderma, Acantholysis, Epidermal acanthosis OMIM:601214
Rat-Bite Fever
Scaling skin ORPHA:31205
Parkes Weber Syndrome
Scaling skin, Skin ulcer ORPHA:90307
Chronic Actinic Dermatitis
Epidermal acanthosis ORPHA:330064
Pachyonychia Congenita 3
Palmoplantar keratoderma, Plantar hyperkeratosis, Palmar hyperkeratosis, Hyperkeratosis OMIM:615726
Iga Pemphigus
Acantholysis, Skin vesicle ORPHA:555905
Neurodevelopmental Disorder With Hypotonia And Dysmorphic Facies
Cutis laxa, Erythema, Scaling skin, Facial erythema, Dry skin OMIM:619503
Woodhouse-Sakati Syndrome
Scaling skin ORPHA:3464
Psoriasis-Related Juvenile Idiopathic Arthritis
Psoriasiform lesion ORPHA:85436
Pseudoxanthoma Elasticum
Civatte bodies, Cutis laxa OMIM:264800
Agammaglobulinemia-Microcephaly-Craniosynostosis-Severe Dermatitis Syndrome
Epidermal acanthosis, Parakeratosis ORPHA:83617


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dmkn

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dmkn.

No publications found that use IMPC mice or data for Dmkn.

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