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Gene: Dmkn MGI:1920962

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
dermokine
Synonyms:
dermokine,  sk89,  1110014F24Rik,  sk30,  Dmkn,  cI-36

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Dmkn mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Dmkn by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Peeling Skin Syndrome 5
Hyperkeratosis, Epidermal acanthosis, Scaling skin OMIM:617115
Keratosis Palmoplantaris Striata Ii
Palmoplantar keratoderma, Epidermal acanthosis OMIM:612908
Epidermolysis Bullosa Simplex 4, Localized Or Generalized Intermediate, Autosomal Recessive
Hyperkeratosis, Epidermal acanthosis OMIM:615028
Ichthyosis Hystrix, Curth-Macklin Type
Hyperkeratotic papule, Palmoplantar keratoderma, Scaling skin OMIM:146590
Palmoplantar Keratoderma, Nagashima Type
Orthokeratotic hyperkeratosis, Epidermal acanthosis, Palmoplantar hyperkeratosis OMIM:615598
Ichthyosis, Congenital, Autosomal Recessive 14
Hyperkeratosis, Orthokeratotic hyperkeratosis, Erythema, Scaling skin OMIM:617571
Acrokeratosis Verruciformis
Hyperkeratosis, Punctate palmoplantar hyperkeratosis, Epidermal acanthosis OMIM:101900
Psoriasis 2
Hyperkeratosis, Parakeratosis, Epidermal acanthosis, Scaling skin OMIM:602723
Keratosis, Focal Palmoplantar And Gingival
Circumungual hyperkeratosis, Subungual hyperkeratosis, Gingival hyperkeratosis, Focal friction-re... OMIM:148730
Erythrokeratodermia Variabilis Et Progressiva 4
Hyperkeratosis, Erythema, Epidermal acanthosis, Palmoplantar hyperkeratosis OMIM:617526
Peeling Skin Syndrome 4
Epidermal acanthosis, Hyperkeratosis, Palmoplantar keratoderma, Scaling skin, Orthokeratosis OMIM:607936
Ichthyosis, Annular Epidermolytic, 2
Erythema, Palmoplantar hyperkeratosis, Palmoplantar keratoderma, Scaling skin, Orthokeratosis OMIM:620148
Hereditary Palmoplantar Keratoderma, Gamborg-Nielsen Type
Hyperkeratosis with erythema, Diffuse palmoplantar hyperkeratosis ORPHA:86923
Verrucous Hemangioma
Hyperkeratotic papule, Epidermal acanthosis ORPHA:464318
Epidermolytic Hyperkeratosis 1
Epidermal acanthosis, Scaling skin, Palmoplantar hyperkeratosis OMIM:113800
Ichthyosis Hystrix, Lambert Type
Hyperkeratosis, Orthokeratotic hyperkeratosis OMIM:146600
Peeling Skin Syndrome 6
Orthokeratosis, Parakeratosis, Dry skin, Scaling skin OMIM:618084
Infantile Digital Fibromatosis
Hyperkeratosis, Parakeratosis, Epidermal acanthosis ORPHA:199267
Palmoplantar Keratoderma, Nonepidermolytic, Focal 1
Perioral hyperkeratosis, Palmoplantar keratoderma, Follicular hyperkeratosis OMIM:613000
Krt1-Related Diffuse Nonepidermolytic Keratoderma
Diffuse palmoplantar hyperkeratosis, Nonepidermolytic palmoplantar hyperkeratosis, Erythema, Palm... ORPHA:530838
White Sponge Nevus 2
Hyperparakeratosis, Epidermal acanthosis OMIM:615785
Hyperkeratosis Lenticularis Perstans
Hyperkeratosis lenticularis perstans OMIM:144150
Angioma Serpiginosum, Autosomal Dominant
Hyperkeratosis OMIM:106050
Papillomatosis, Confluent And Reticulated
Hyperkeratosis OMIM:167900
Epidermolysis Bullosa Simplex 1C, Localized
Hyperkeratosis OMIM:131800
Reticulate Acropigmentation Of Kitamura
Hyperkeratosis OMIM:615537
Palmoplantar Keratoderma-Deafness Syndrome
Hyperkeratosis, Palmoplantar keratoderma ORPHA:2202
Palmoplantar Keratoderma, Norrbotten Recessive Type
Hyperkeratosis, Palmoplantar keratoderma OMIM:244850
Palmoplantar Keratoderma, Punctate Type Ia
Orthokeratosis, Punctate palmoplantar hyperkeratosis, Epidermal acanthosis OMIM:148600
Palmoplantar Keratoderma, Punctate Type Iii
Hyperkeratosis OMIM:101850
Ichthyosis, Congenital, Autosomal Recessive 6
Parakeratosis, Epidermal acanthosis, Hyperkeratosis, Palmoplantar keratoderma, Scaling skin, Orth... OMIM:612281
Dermatoleukodystrophy
Hyperkeratosis ORPHA:1659
Ichthyosis, Annular Epidermolytic, 1
Erythema, Hyperparakeratosis, Palmoplantar hyperkeratosis, Scaling skin, Orthokeratosis OMIM:607602
Peeling Skin Syndrome 2
Erythema, Scaling skin OMIM:609796
Ichthyosis, Congenital, Autosomal Recessive 5
Parakeratosis, Epidermal acanthosis, Palmoplantar keratoderma, Orthokeratosis, White scaling skin OMIM:604777
Erythrokeratodermia Variabilis Et Progressiva 1
Generalized hyperkeratosis, Patchy palmoplantar hyperkeratosis, Epidermal acanthosis OMIM:133200
Dowling-Degos Disease 2
Hyperkeratotic papule, Follicular hyperkeratosis OMIM:615327
Ichthyosis, Congenital, Autosomal Recessive 12
White scaling skin OMIM:617320
Palmoplantar Keratoderma, Nonepidermolytic, Focal Or Diffuse
Plantar hyperkeratosis, Palmoplantar keratoderma, Epidermal acanthosis OMIM:615735
Seborrhea-Like Dermatitis With Psoriasiform Elements
Hyperkeratosis, Epidermal acanthosis OMIM:610227
Keratoderma Hereditarium Mutilans With Ichthyosis
Parakeratosis, Scaling skin on fingertip, Epidermal acanthosis, Honeycomb palmoplantar hyperkerat... ORPHA:79395
Ichthyosis, Congenital, Autosomal Recessive 8
Orthokeratosis, Hyperkeratosis, Erythema, Epidermal acanthosis OMIM:613943
Erythrokeratodermia Variabilis Et Progressiva 5
Hyperkeratosis, Palmoplantar hyperkeratosis OMIM:617756
Ichthyosis, Lamellar, Autosomal Dominant
Hyperkeratosis OMIM:146750
Ichthyosis, Congenital, Autosomal Recessive 13
Hyperkeratosis, Palmoplantar hyperkeratosis OMIM:617574
Peeling Skin Syndrome 3
Erythema, White scaling skin OMIM:616265
Olmsted Syndrome, X-Linked
Subungual hyperkeratosis, Parakeratosis, Epidermal acanthosis, Palmoplantar hyperkeratosis, Hyper... OMIM:300918
Erythrokeratodermia Variabilis Et Progressiva 3
Epidermal acanthosis, Erythema, Hyperkeratosis, Palmoplantar keratoderma, Orthokeratosis OMIM:617525
Epidermolytic Palmoplantar Keratoderma
Epidermal acanthosis, Epidermal hyperkeratosis, Diffuse palmoplantar hyperkeratosis, Palmoplantar... ORPHA:2199
Peeling Skin With Leukonychia, Acral Punctate Keratoses, Cheilitis, And Knuckle Pads
Epidermal acanthosis, Acantholysis, Punctate palmoplantar hyperkeratosis, Hyperkeratosis, Scaling... OMIM:616295
Bazex Syndrome
Hyperkeratosis, Parakeratosis, Palmoplantar keratoderma, Scaling skin ORPHA:166113
Elastosis Perforans Serpiginosa
Hyperkeratotic papule, Epidermal acanthosis, Cutis laxa ORPHA:79148
Atrophoderma Vermiculata
Abnormal epidermal morphology, Erythema, Hyperkeratotic papule, Follicular hyperkeratosis ORPHA:79100
Bathing Suit Ichthyosis
Parakeratosis, Epidermal acanthosis, Palmoplantar hyperkeratosis, Palmoplantar scaling skin, Scal... ORPHA:100976
Ichthyosis-Alopecia-Eclabion-Ectropion-Intellectual Disability Syndrome
Epidermal acanthosis, Cutis laxa, Scaling skin, Dry skin, Generalized hyperkeratosis ORPHA:2269
Hyperkeratosis-Hyperpigmentation Syndrome
Hyperkeratosis ORPHA:1336
Amyloidosis, Primary Localized Cutaneous, 1
Dry skin, Scaling skin OMIM:105250
Familial Benign Chronic Pemphigus
Skin vesicle, Hyperkeratosis, Erythema, Acantholysis ORPHA:2841
Erythrokeratoderma ''En Cocardes''
Hyperkeratosis ORPHA:315
Dowling-Degos Disease 4
Epidermal acanthosis OMIM:615696
Palmoplantar Keratoderma I, Striate, Focal, Or Diffuse
Epidermal acanthosis, Palmoplantar hyperkeratosis, Orthokeratotic hyperkeratosis, Palmoplantar ke... OMIM:148700
Familial Reactive Perforating Collagenosis
Abnormal epidermal morphology, Hyperkeratotic papule ORPHA:79147
Epidermolytic Hyperkeratosis 2
Palmoplantar hyperkeratosis, Hyperkeratosis, Cobblestone-like hyperkeratosis, Palmoplantar kerato... OMIM:620150
Acral Self-Healing Collodion Baby
Palmoplantar scaling skin, Erythema, Lack of skin elasticity ORPHA:281127
Porokeratosis Of Mibelli
Hyperkeratosis ORPHA:735
Mal De Meleda
Erythema, Nonepidermolytic palmoplantar hyperkeratosis, Epidermal acanthosis, Palmoplantar kerato... ORPHA:87503
Ichthyosis, Congenital, Autosomal Recessive 7
Palmoplantar keratoderma, Epidermal acanthosis OMIM:615022
Hypotrichosis Simplex Of The Scalp
Hyperkeratosis, Parakeratosis, Epidermal acanthosis, Scaling skin ORPHA:90368
Cole Disease
Epidermal acanthosis, Punctate palmoplantar hyperkeratosis, Hyperkeratosis, Palmoplantar keratode... OMIM:615522
Acral Peeling Skin Syndrome
Erythema, Scaling skin, Excessive wrinkling of palmar skin ORPHA:263534
Ichthyosis, Spastic Quadriplegia, And Impaired Intellectual Development
Hyperkeratosis, Erythema, Dry skin, Scaling skin OMIM:614457
Acrokeratoelastoidosis Of Costa
Orthokeratosis, Hyperkeratotic papule, Epidermal acanthosis, Palmoplantar hyperkeratosis ORPHA:38
Olmsted Syndrome 2
Parakeratosis, Epidermal acanthosis, Perioral hyperkeratosis, Palmoplantar hyperkeratosis, Hyperk... OMIM:619208
Ectodermal Dysplasia/Skin Fragility Syndrome
Scaling skin, Palmoplantar hyperkeratosis OMIM:604536
Glycogen Storage Disease Due To Lactate Dehydrogenase M-Subunit Deficiency
Parakeratosis, Psoriasiform lesion, Scaling skin ORPHA:284426
Vohwinkel Syndrome, Variant Form
Orthokeratosis, Hyperkeratosis, Parakeratosis, Honeycomb palmoplantar hyperkeratosis OMIM:604117
Singleton-Merten Syndrome 2
Hyperkeratosis, Psoriasiform lesion OMIM:616298
Palmoplantar Keratoderma And Congenital Alopecia 2
Hyperkeratosis, Dry skin, Palmoplantar hyperkeratosis, Facial erythema OMIM:212360
Epidermolysis Bullosa Dystrophica, Pretibial
Hyperkeratosis OMIM:131850
Idiopathic Localized Lipodystrophy
Erythema, Scaling skin ORPHA:90158
Ichthyosis With Confetti
Scaling skin, Palmoplantar hyperkeratosis OMIM:609165
Vulvovaginal Gingival Syndrome
Parakeratosis, Erythema, Epidermal acanthosis ORPHA:83453
Acrokeratosis Verruciformis Of Hopf
Parakeratosis, Epidermal acanthosis, Acantholysis, Punctate palmoplantar hyperkeratosis, Hyperker... ORPHA:79151
Pemphigus Foliaceus
Skin vesicle, Erythema, Scaling skin, Acantholysis ORPHA:79481
Lipoid Proteinosis Of Urbach And Wiethe
Hyperkeratosis, Reduced epidermal extracellular matrix protein 1 protein expression OMIM:247100
Congenital Disorder Of Glycosylation, Type If
Hyperkeratosis, Dry skin, Scaling skin OMIM:609180
Superficial Epidermolytic Ichthyosis
Erythema, Palmoplantar keratoderma, Acantholysis ORPHA:455
Cancer, Alopecia, Pigment Dyscrasia, Onychodystrophy, And Keratoderma
Palmoplantar keratoderma, Scaling skin, Dry skin OMIM:618373
Hypercarotenemia And Vitamin A Deficiency, Autosomal Recessive
Follicular hyperkeratosis OMIM:277350
Aicardi-Goutieres Syndrome 5
Dry skin, Scaling skin OMIM:612952
Angioma Serpiginosum, X-Linked
Hyperkeratosis OMIM:300652
Lupus Erythematosus Tumidus
Scaling skin ORPHA:90283
Porokeratosis 7, Multiple Types
Parakeratosis OMIM:614714
Porokeratosis 1, Multiple Types
Parakeratosis OMIM:175800
Ichthyosis Vulgaris
Absent keratohyalin granules, Dry skin OMIM:146700
Ichthyosis, Congenital, Autosomal Recessive 9
Orthokeratosis, Hyperkeratosis, Epidermal acanthosis OMIM:615023
Recessive X-Linked Ichthyosis
Hyperkeratosis, Dry skin ORPHA:461
Cardiomyopathy, Dilated, With Woolly Hair And Keratoderma
Acantholysis, Palmoplantar hyperkeratosis, Palmoplantar scaling skin, Palmoplantar keratoderma, P... OMIM:605676
Basan Syndrome
Palmoplantar keratoderma, Epidermal acanthosis OMIM:129200
Acute Radiation Syndrome
Hyperkeratosis, Scaling skin, Skin ulcer ORPHA:454831
Acquired Ichthyosis
Hyperkeratosis, Erythema, Palmoplantar keratoderma, Dry skin ORPHA:454
Subacute Cutaneous Lupus Erythematosus
Hyperkeratosis, Psoriasiform lesion ORPHA:163525
Ichthyosis, Congenital, Autosomal Recessive 10
Hyperkeratosis, Orthokeratotic hyperkeratosis, Palmoplantar keratoderma OMIM:615024
Huriez Syndrome
Congenital palmoplantar hyperkeratosis, Epidermal acanthosis OMIM:181600
Intellectual Developmental Disorder, Fra12A Type
Hyperkeratosis OMIM:136630
Hyperkeratosis Lenticularis Perstans
Hyperkeratosis lenticularis perstans, Skin ulcer ORPHA:409
Acute Generalized Exanthematous Pustulosis
Skin vesicle, Purpura, Scaling skin, Acantholysis ORPHA:293173
Hypotrichosis And Recurrent Skin Vesicles
Skin vesicle, Epidermal acanthosis, Follicular hyperkeratosis OMIM:613102
Tylosis With Esophageal Cancer
Diffuse palmoplantar hyperkeratosis, Parakeratosis, Follicular hyperkeratosis OMIM:148500
Pityriasis Rubra Pilaris
Orthokeratosis, Subungual hyperkeratosis, Parakeratosis, Palmoplantar keratoderma OMIM:173200
Centrifugal Lipodystrophy
Erythema, Scaling skin ORPHA:90156
Ectodermal Dysplasia/Short Stature Syndrome
Hyperkeratosis, Palmoplantar keratoderma, Epidermal acanthosis OMIM:616029
Irida Syndrome
Hyperkeratosis, Pallor ORPHA:209981
Cutaneous Mastocytoma
Erythema, Scaling skin ORPHA:79455
Autosomal Dominant Epidermolytic Ichthyosis
Hyperkeratosis, Palmoplantar keratoderma, Skin ulcer ORPHA:312
Proteus Syndrome
Hyperkeratosis, Epidermal acanthosis OMIM:176920
Peeling Skin Syndrome 1
Scaling skin OMIM:270300
Ichthyosis Prematurity Syndrome
Epidermal acanthosis, Follicular hyperkeratosis OMIM:608649
Porokeratosis 3, Multiple Types
Parakeratosis OMIM:175900
Ichthyosis, Congenital, Autosomal Recessive 1
Parakeratosis, Epidermal acanthosis, Palmoplantar hyperkeratosis OMIM:242300
Palmoplantar Carcinoma, Multiple Self-Healing
Parakeratosis, Palmoplantar keratoderma, Epidermal acanthosis, Follicular hyperkeratosis OMIM:615225
Lichen Planus Pemphigoides
Skin vesicle, Hyperkeratosis ORPHA:254478
Familial Keratoacanthoma
Hyperkeratosis, Skin ulcer ORPHA:493
Epidermodysplasia Verruciformis, Susceptibility To, 3
Epidermal acanthosis OMIM:618267
Pachyonychia Congenita 1
Follicular hyperkeratosis, Palmoplantar hyperkeratosis OMIM:167200
Autosomal Dominant Palmoplantar Keratoderma And Congenital Alopecia
Palmoplantar keratoderma, Scaling skin, Dry skin, Facial erythema ORPHA:1010
Pemphigus Vulgaris
Acantholysis ORPHA:704
Psoriasis 14, Pustular
Parakeratosis, Erythema, Epidermal acanthosis OMIM:614204
Ichthyosis, Congenital, Autosomal Recessive 2
Hyperkeratosis, Erythema, Palmoplantar keratoderma, Epidermal acanthosis OMIM:242100
Punctate Palmoplantar Keratoderma Type 1
Epidermal acanthosis, Abnormal epidermal morphology, Palmoplantar hyperkeratosis, Palmoplantar ke... ORPHA:79501
Ichthyotic Keratoderma, Spasticity, Hypomyelination, And Dysmorphic Facial Features
Hyperkeratosis, Parakeratosis, Dry skin, Epidermal acanthosis OMIM:618527
Mpdu1-Cdg
Scaling skin ORPHA:79323
Diffuse Cutaneous Mastocytosis
Scaling skin ORPHA:79456
Recon Progeroid Syndrome
Dry skin, Scaling skin OMIM:620370
Ichthyosis, Congenital, Autosomal Recessive 3
Hyperkeratosis, Erythema, Palmoplantar keratoderma OMIM:606545
Kid Syndrome
Palmoplantar keratoderma, Epidermal acanthosis, Scaling skin, Follicular hyperkeratosis ORPHA:477
Autoinflammation With Arthritis And Dyskeratosis
Dry skin, Epidermal acanthosis, Follicular hyperkeratosis, Palmoplantar hyperkeratosis OMIM:617388
Ectodermal Dysplasia-Skin Fragility Syndrome
Palmoplantar keratoderma, Scaling skin, Follicular hyperkeratosis ORPHA:158668
X-Linked Dominant Chondrodysplasia Punctata
Scaling skin ORPHA:35173
Darier-White Disease
Subungual hyperkeratotic fragments, Acantholysis OMIM:124200
Odontoonychodermal Dysplasia
Plantar hyperkeratosis, Epidermal acanthosis, Erythema, Palmoplantar hyperkeratosis, Follicular h... OMIM:257980
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity
Scaling skin OMIM:606367
Immunodeficiency 58
Psoriasiform lesion, Scaling skin OMIM:618131
Graft Versus Host Disease
Scaling skin ORPHA:39812
Ichthyosis, Leukocyte Vacuoles, Alopecia, And Sclerosing Cholangitis
Orthokeratosis, Parakeratosis, Dry skin, Epidermal acanthosis OMIM:607626
Naxos Disease
Subungual hyperkeratosis, Epidermal acanthosis, Acantholysis, Diffuse palmoplantar hyperkeratosis... OMIM:601214
Bacterial Toxic-Shock Syndrome
Ecchymosis, Scaling skin ORPHA:36234
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Psoriasiform lesion ORPHA:169154
Porphyria Cutanea Tarda
Scaling skin ORPHA:101330
Focal Facial Dermal Dysplasia Type Iv
Abnormal epidermal morphology ORPHA:398189
Inflammatory Skin And Bowel Disease, Neonatal, 2
Epidermal acanthosis OMIM:616069
Myoectodermal Gonadal Dysgenesis Syndrome
Dry skin, Scaling skin OMIM:618419
Pemphigus Erythematosus
Acantholysis ORPHA:79480
Riddle Syndrome
Erythema, Scaling skin ORPHA:420741
Restrictive Dermopathy
Dermal translucency, Generalized hyperkeratosis, Scaling skin, Epidermal hyperkeratosis ORPHA:1662
Immunodeficiency, Common Variable, 8, With Autoimmunity
Psoriasiform lesion OMIM:614700
Chronic Recurrent Multifocal Osteomyelitis 2, With Periostitis And Pustulosis
Hyperkeratosis, Epidermal acanthosis OMIM:612852
Neonatal Inflammatory Skin And Bowel Disease
Erythema, Scaling skin ORPHA:294023
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Dry skin, Scaling skin, Skin ulcer ORPHA:2526
Ifap Syndrome 1, With Or Without Bresheck Syndrome
Subungual hyperkeratosis, Perianal erythema, Hyperkeratosis, Scaling skin, Follicular hyperkerato... OMIM:308205
Parkes Weber Syndrome
Scaling skin, Skin ulcer ORPHA:90307
Chronic Actinic Dermatitis
Epidermal acanthosis ORPHA:330064
Restrictive Dermopathy 1
Scaling skin, Epidermal hyperkeratosis OMIM:275210
Rat-Bite Fever
Scaling skin ORPHA:31205
Neurodevelopmental Disorder With Hypotonia And Dysmorphic Facies
Erythema, Cutis laxa, Facial erythema, Scaling skin, Dry skin OMIM:619503
Congenital Hemidysplasia With Ichthyosiform Erythroderma And Limb Defects
Parakeratosis, Epidermal acanthosis, Erythema, Hyperkeratosis, Orthokeratosis OMIM:308050
Woodhouse-Sakati Syndrome
Scaling skin ORPHA:3464
Psoriasis-Related Juvenile Idiopathic Arthritis
Psoriasiform lesion ORPHA:85436
Pseudoxanthoma Elasticum
Civatte bodies, Cutis laxa OMIM:264800
Agammaglobulinemia-Microcephaly-Craniosynostosis-Severe Dermatitis Syndrome
Parakeratosis, Epidermal acanthosis ORPHA:83617

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dmkn

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dmkn.

No publications found that use IMPC mice or data for Dmkn.

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