IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
|Phenotype||System||Allele||Zyg||Sex||Life Stage||P Value|
|increased heart weight||Spns1tm1e(EUCOMM)Wtsi||HET||Early adult||7.62×10-06|
|increased total body fat amount||Spns1tm1e(EUCOMM)Wtsi||HET||Early adult||4.77×10-05|
|increased lean body mass||Spns1tm1e(EUCOMM)Wtsi||HET||Early adult||2.47×10-07|
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Spns1 by phenotypic similarity.
|Cardiomyopathy, Dilated, 1I||
||Dilated cardiomyopathy, Cardiomegaly||OMIM:604765|
|Obesity-Colitis-Hypothyroidism-Cardiac Hypertrophy-Developmental Delay Syndrome||
|Cardiomyopathy, Familial Hypertrophic 27||
||Right ventricular hypertrophy, Concentric hypertrophic cardiomyopathy, Endocardial fibroelastosis...||OMIM:618052|
|Congenitally Uncorrected Transposition Of The Great Arteries||
||Abnormal pulmonary valve morphology, Abnormal mitral valve morphology, Failure to thrive, Anomalo...||ORPHA:860|
|Congenital Tricuspid Valve Dysplasia||
||Tricuspid valve prolapse, Right atrial enlargement, Anomalous pulmonary venous return, Hepatomega...||ORPHA:555874|
||Bicuspid aortic valve, Hypoplastic left heart, Aortic valve atresia, Tetralogy of Fallot, Abnorma...||ORPHA:1457|
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|MGI Allele||Allele Type||Produced|
|Spns1tm1e(EUCOMM)Wtsi||Targeted, non-conditional allele||Mice, ES Cells|
|Spns1tm1e(EUCOMM)Hmgu||Targeted, non-conditional allele||ES Cells|
|Spns1tm1a(EUCOMM)Wtsi||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors, ES Cells|