IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Cldn34b2 by phenotypic similarity.
|Pseudohypoaldosteronism, Type Iib||
|Pseudohypoaldosteronism, Type Iid||
|Pseudohypoaldosteronism, Type Iie||
|Pseudohypoaldosteronism, Type Iic||
||Decreased circulating renin level, Hyperchloremia, Hyperkalemia||OMIM:614492|
|Bartter Syndrome, Type 5, Antenatal, Transient||
||Hypokalemia, Hypochloremia, Increased circulating renin level, Hyponatremia||OMIM:300971|
|Diarrhea 1, Secretory Chloride, Congenital||
||Increased circulating renin level, Hypokalemia, Hypochloremia, Hyponatremia||OMIM:214700|
|Bartter Syndrome, Type 4B, Neonatal, With Sensorineural Deafness||
||Hyperchloriduria, Hypokalemia, Hypochloremia, Hyponatremia||OMIM:613090|
|Bartter Syndrome, Type 4A, Neonatal, With Sensorineural Deafness||
||Hyperchloriduria, Hypokalemia, Hypochloremia, Hyponatremia||OMIM:602522|
|Bartter Syndrome, Type 1, Antenatal||
||Increased serum prostaglandin E2, Hypokalemia, Increased circulating renin level, Hyperchloriduri...||OMIM:601678|
|Bartter Syndrome Type 4||
||Hypokalemia, Increased circulating renin level, Hypochloremia, Hyponatremia, Hypomagnesemia||ORPHA:89938|
|Bartter Syndrome, Type 2, Antenatal||
||Increased serum prostaglandin E2, Hypokalemia, Increased circulating renin level, Hyperchloriduri...||OMIM:241200|
|Classic Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency||
||Hypochloremia, Hyperkalemia, Hyponatremia||ORPHA:90794|
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|MGI Allele||Allele Type||Produced|
|Cldn34b2tm1a(KOMP)Wtsi||KO first allele (reporter-tagged insertion with conditional potential)||Mice, Targeting vectors, ES Cells|
|Cldn34b2tm1e(KOMP)Wtsi||Targeted, non-conditional allele||ES Cells|
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