Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
2900045C01Rik,  testican 3

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Spock3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Spock3 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Glycosylphosphatidylinositol Biosynthesis Defect 17
Overfriendliness, Aggressive behavior, Dysplastic corpus callosum, Primary microcephaly OMIM:618010
Schizencephaly, Agenesis of corpus callosum, Cerebral cortical atrophy OMIM:269160
Chudley-Mccullough Syndrome
Partial agenesis of the corpus callosum, Hypoplasia of the corpus callosum, Dysplastic corpus cal... OMIM:604213
Sin3A-Related Intellectual Disability Syndrome Due To A Point Mutation
Mild malformation of cortical development, Dysplastic corpus callosum, Abnormal cerebral white ma... ORPHA:500166
Childhood-Onset Benign Chorea With Striatal Involvement
Anxiety, Abnormal corpus striatum morphology, Striatal T2 hyperintensity ORPHA:494541
Neurodegeneration, Childhood-Onset, With Cerebellar Atrophy
Dysplastic corpus callosum, Poor eye contact, Microcephaly OMIM:618276
Spastic Paraplegia 45, Autosomal Recessive
Hypoplasia of the corpus callosum, Dysplastic corpus callosum OMIM:613162
Prkar1B-Related Neurodegenerative Dementia With Intermediate Filaments
Frontotemporal cerebral atrophy, Inappropriate behavior, Abnormal neuron morphology, Apathy, Diff... ORPHA:412066
Cortical Dysplasia, Complex, With Other Brain Malformations 7
Unilateral polymicrogyria, Lissencephaly, Pachygyria, Hypoplasia of the corpus callosum, Agenesis... OMIM:610031
Cortical Dysplasia, Complex, With Other Brain Malformations 1
Lissencephaly, Polymicrogyria, Hypoplasia of the corpus callosum, Cortical dysplasia, Agenesis of... OMIM:614039
Neurodevelopmental Disorder With Microcephaly And Structural Brain Anomalies
Aggressive behavior, Absent septum pellucidum, Simplified gyral pattern, Cerebral atrophy, Hypopl... OMIM:618492
Sub-Cortical Nodular Heterotopia
Abnormal cerebral cortex morphology, Polymicrogyria, Abnormality of the basal ganglia, Hypoplasia... ORPHA:101029
Mirror Movements 1
Agenesis of corpus callosum OMIM:157600
Lissencephaly 4
Microcephaly, Lissencephaly, Agenesis of corpus callosum, Simplified gyral pattern OMIM:614019
Glycine Encephalopathy
Aggressive behavior, Irritability, Agenesis of corpus callosum, Impulsivity OMIM:605899
Microcephaly 5, Primary, Autosomal Recessive
Small cerebral cortex, Simplified gyral pattern, Hypoplasia of the corpus callosum, Cortical dysp... OMIM:608716
Microcephaly-Polymicrogyria-Corpus Callosum Agenesis Syndrome
Polymicrogyria, Agenesis of corpus callosum, Primary microcephaly ORPHA:171703
Lissencephaly 3
Lissencephaly, Pachygyria, Polymicrogyria, Agyria, Hypoplasia of the corpus callosum, Agenesis of... OMIM:611603
Polymicrogyria With Optic Nerve Hypoplasia
Colpocephaly, Agenesis of corpus callosum, Dysplastic corpus callosum, Polymicrogyria ORPHA:250972
Infantile Osteopetrosis With Neuroaxonal Dysplasia
Partial agenesis of the corpus callosum, Hypoplastic hippocampus, Agenesis of corpus callosum, Ce... ORPHA:85179
Polymicrogyria Due To Tubb2B Mutation
Perisylvian polymicrogyria, Schizencephaly, Dysgenesis of the basal ganglia, Abnormal caudate nuc... ORPHA:300573
Abnormal fear/anxiety-related behavior, Agoraphobia, Claustrophobia, Irritability, Emotional labi... ORPHA:66624
Midline Malformations, Multiple, With Limb Abnormalities And Hypopituitarism
Dysplastic corpus callosum, Anterior hypopituitarism OMIM:601016
Joubert Syndrome 23
Dysplastic corpus callosum OMIM:616490
Mucolipidosis Iv
Cerebral dysmyelination, Dysplastic corpus callosum, Microcephaly OMIM:252650
Microcephaly, Amish Type
Partial agenesis of the corpus callosum, Progressive microcephaly, Irritability OMIM:607196
Combined Oxidative Phosphorylation Deficiency 12
Hypoplasia of the corpus callosum, Dysplastic corpus callosum, Leukoencephalopathy OMIM:614924
Microcephaly, Short Stature, And Polymicrogyria With Or Without Seizures
Dysplastic corpus callosum, Polymicrogyria, Lissencephaly, Agenesis of corpus callosum, Microcephaly OMIM:614833
Osteopetrosis And Infantile Neuroaxonal Dystrophy
Hypoplastic hippocampus, Agenesis of corpus callosum, Cerebral atrophy OMIM:600329
Severe Growth Deficiency-Strabismus-Extensive Dermal Melanocytosis-Intellectual Disability Syndrome
Multifocal cerebral white matter abnormalities, Dysplastic corpus callosum, Aggressive behavior, ... ORPHA:488627
Familial Congenital Mirror Movements
Morphological abnormality of the corticospinal tract, Dysgenesis of the hippocampus, Agenesis of ... ORPHA:238722
Early-Onset Schizophrenia
Shyness, No social interaction, Unhappy demeanor, Low self esteem, Suicidal ideation, Lack of pee... ORPHA:96369
Hypotonia, Infantile, With Psychomotor Retardation And Characteristic Facies 3
Dysplastic corpus callosum, Small basal ganglia, Periventricular leukomalacia, Cerebral atrophy, ... OMIM:616900
Pyruvate Dehydrogenase E1-Beta Deficiency
Agenesis of corpus callosum OMIM:614111
Ectodermal Dysplasia, Hypohidrotic, With Hypothyroidism And Agenesis Of The Corpus Callosum
Agenesis of corpus callosum OMIM:225040
Even-Plus Syndrome
Dysplastic corpus callosum, Agenesis of corpus callosum OMIM:616854
Hydranencephaly, Self-mutilation, Pachygyria, Agenesis of corpus callosum, Microcephaly OMIM:605013
Pontocerebellar Hypoplasia Type 2
Abnormal cortical gyration, Progressive microcephaly, Hypoplasia of the corpus callosum, Dysplast... ORPHA:2524
Neurodevelopmental Disorder With Dysmorphic Facies, Sleep Disturbance, And Brain Abnormalities
Partial agenesis of the corpus callosum, Dysplastic corpus callosum, Focal polymicrogyria, Head-b... OMIM:619103
Global Developmental Delay-Alopecia-Macrocephaly-Facial Dysmorphism-Structural Brain Anomalies Syndrome
Dilated third ventricle, Dysplastic corpus callosum, Periventricular cysts, Self-injurious behavi... ORPHA:544488
Oculocerebrodental Syndrome
Focal white matter lesions, Dysplastic corpus callosum, Abnormality of thalamus morphology ORPHA:557003
Microphthalmia, Syndromic 11
Agenesis of pineal gland, Agenesis of corpus callosum OMIM:614402
Neurodevelopmental Disorder With Ataxia, Hypotonia, And Microcephaly
Hypoplasia of the corpus callosum, Dysplastic corpus callosum, Head-banging, Microcephaly OMIM:618569
Septooptic Dysplasia
Anterior pituitary hypoplasia, Decreased response to growth hormone stimulation test, Agenesis of... OMIM:182230
Microcephaly 26, Primary, Autosomal Dominant
Dysplastic corpus callosum, Simplified gyral pattern, Pachygyria, Hypoplasia of the corpus callos... OMIM:619179
Combined Oxidative Phosphorylation Deficiency 53
Secondary microcephaly, Dysplastic corpus callosum OMIM:619423
Cerebrofacioarticular Syndrome
Dysplastic corpus callosum, Self-injurious behavior, Hypoplasia of the corpus callosum, Agenesis ... ORPHA:314679
Kapur-Toriello Syndrome
Pachygyria, Dysplastic corpus callosum, Polymicrogyria ORPHA:2328
Autosomal Recessive Cutis Laxa Type 2A
Dysplastic corpus callosum, Primary microcephaly, Pachygyria, Thick cerebral cortex, Secondary mi... ORPHA:357058
Pontocerebellar Hypoplasia, Hypotonia, And Respiratory Insufficiency Syndrome, Neonatal Lethal
Dysplastic corpus callosum OMIM:618810
Thoc6-Related Developmental Delay-Microcephaly-Facial Dysmorphism Syndrome
Dysplastic corpus callosum ORPHA:363444
White-Kernohan Syndrome
Anxiety, Dysplastic corpus callosum OMIM:619426
Intellectual Developmental Disorder, X-Linked, Syndromic 34
Pineal cyst, Dysplastic corpus callosum, Aggressive behavior, Thick corpus callosum, Impulsivity OMIM:300967
Genitourinary And/Or Brain Malformation Syndrome
Dysplastic corpus callosum, Colpocephaly, Absent septum pellucidum, Polymicrogyria, Secondary mic... OMIM:618820
Witteveen-Kolk Syndrome
Dysplastic corpus callosum, Aggressive behavior, Conspicuously happy disposition, Decreased respo... OMIM:613406
Macrocephaly-Intellectual Disability-Left Ventricular Non Compaction Syndrome
Shyness, Dysplastic corpus callosum, Aggressive behavior, Anterior pituitary hypoplasia, Anxiety,... ORPHA:466791
Zttk Syndrome
Hypoplasia of the corpus callosum, Dysplastic corpus callosum, Periventricular leukomalacia, Abno... OMIM:617140
Brain Malformations-Musculoskeletal Abnormalities-Facial Dysmorphism-Intellectual Disability Syndrome
Dysplastic corpus callosum, Abnormal cerebral cortex morphology, Simplified gyral pattern, Polymi... ORPHA:500150


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Spock3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Spock3.

No publications found that use IMPC mice or data for Spock3.

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MGI Allele Allele Type Produced
Spock3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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