Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
pale yolk sac | Sass6em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
abnormal pericardium morphology | Sass6em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
abnormal embryo turning | Sass6em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
edema | Sass6em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
abnormal tail bud morphology | Sass6em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
preweaning lethality, complete penetrance | Sass6em1(IMPC)Bay | HOM | Early adult | 0.00 | ||
abnormal vitelline vasculature morphology | Sass6em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
abnormal heart looping | Sass6em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
abnormal neural tube morphology | Sass6em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
abnormal pharyngeal arch morphology | Sass6em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
abnormal somite shape | Sass6em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
abnormal midbrain development | Sass6em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
abnormal optic vesicle formation | Sass6em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
embryonic growth retardation | Sass6em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
abnormal heart morphology | Sass6em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
abnormal forebrain development | Sass6em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
abnormal neural tube closure | Sass6em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
abnormal embryo size | Sass6em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
abnormal hindbrain development | Sass6em1(IMPC)Bay | HOM | E9.5 | 0.00 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Sass6 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Autosomal Recessive Primary Microcephaly | Short stature, Growth delay | ORPHA:2512 | |
Microcephaly 14, Primary, Autosomal Recessive | OMIM:616402 |
The table below shows human diseases predicted to be associated to Sass6 by phenotypic similarity.
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MGI Allele | Allele Type | Produced |
---|---|---|
Sass6tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Sass6em1(IMPC)Bay | Exon Deletion | Mice |
Sass6tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
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