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Gene: Cul4b MGI:1919834

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
cullin 4B
Synonyms:
2700050M05Rik

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Cul4b mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Cul4b by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Intellectual Developmental Disorder, X-Linked, Syndromic, Cabezas Type
Delayed puberty, Abdominal obesity, Striae distensae, Short stature OMIM:300354
X-Linked Intellectual Disability, Cabezas Type
Short stature, Cachexia, Obesity ORPHA:85293

The table below shows human diseases predicted to be associated to Cul4b by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Placental Insufficiency
Abnormal placenta morphology, Small placenta, Proportionate short stature, Abnormal umbilical cor... ORPHA:439167
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency
Postnatal growth retardation, Small placenta, Severe postnatal growth retardation, Severe intraut... ORPHA:73272
Silver-Russell Syndrome Due To A Point Mutation
Postnatal growth retardation, Small placenta, Intrauterine growth retardation, Oligohydramnios, S... ORPHA:397590
Silver-Russell Syndrome Due To 11P15 Microduplication
Postnatal growth retardation, Decreased fetal movement, Severe intrauterine growth retardation, S... ORPHA:231144
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Hypermethylation
Postnatal growth retardation, Large for gestational age, Large placenta, Polyhydramnios, Umbilica... ORPHA:254534
Methylmalonic Acidemia With Homocystinuria, Type Cbld
Failure to thrive, Pallor ORPHA:79283
Osteoporosis-Oculocutaneous Hypopigmentation Syndrome
Short stature, Pallor ORPHA:2786
Myopathy, Lactic Acidosis, And Sideroblastic Anemia 2
Growth delay, Failure to thrive, Pallor OMIM:613561
Fetal Akinesia Deformation Sequence 1
Short umbilical cord, Stillbirth, Polyhydramnios, Small placenta, Increased nuchal translucency, ... OMIM:208150
Hereditary Persistence Of Fetal Hemoglobin-Beta-Thalassemia Syndrome
Pallor ORPHA:46532
Congenital Heart Block
Hydrops fetalis, Premature birth, Intrauterine growth retardation, Pallor, Oligohydramnios, Vagin... ORPHA:60041
Peripheral Cone Dystrophy
Pallor OMIM:609021
Cone-Rod Dystrophy 11
Pallor OMIM:610381
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Microdeletion
Postnatal growth retardation, Large placenta, Polyhydramnios, Redundant neck skin, Umbilical hern... ORPHA:254528
Acute Peripheral Arterial Occlusion
Pallor ORPHA:90064
Acute Myelomonocytic Leukemia
Pallor, Weight loss ORPHA:517
Dermatitis, Atopic
Pallor, Facial erythema, Dry skin OMIM:603165
Benign Paroxysmal Torticollis Of Infancy
Pallor ORPHA:71518
Restrictive Dermopathy
Scaling skin, Short umbilical cord, Large placenta, Polyhydramnios, Small placenta, Premature bir... ORPHA:1662
Cyclic Vomiting Syndrome
Growth delay, Pallor OMIM:500007
Leber Congenital Amaurosis 14
Pallor OMIM:613341
Thiamine-Responsive Megaloblastic Anemia Syndrome
Short stature, Pallor ORPHA:49827
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Pallor, Increased body weight ORPHA:276608
Anemia, Congenital Dyserythropoietic, Type Ib
Growth delay, Pallor, Short stature OMIM:615631
Neu-Laxova Syndrome 1
Short umbilical cord, Stillbirth, Polyhydramnios, Small placenta, Hydranencephaly, Spina bifida, ... OMIM:256520
Optic Atrophy 1
Pallor OMIM:165500
Renal Tubular Acidosis, Distal, 4, With Hemolytic Anemia
Short stature, Failure to thrive, Pallor OMIM:611590
Congenital Syphilis
Palmoplantar scaling skin, Large placenta, Hydrops fetalis, Purpura, Petechiae, Premature birth, ... ORPHA:499009
Familial Focal Epilepsy With Variable Foci
Pallor ORPHA:98820
Hemoglobin D Disease
Pallor ORPHA:90039
Fanconi Anemia, Complementation Group I
Intrauterine growth retardation, Pallor, Decreased body weight, Short stature OMIM:609053
Hyperinsulinism Due To Hnf1A Deficiency
Large for gestational age, Pallor, Small for gestational age ORPHA:324575
Breath-Holding Spells
Pallor OMIM:607578
Primary Lateral Sclerosis, Juvenile
Pallor OMIM:606353
Optic Atrophy 7 With Or Without Auditory Neuropathy
Pallor OMIM:612989
Pyruvate Kinase Deficiency Of Red Cells
Intrauterine growth retardation, Pallor, Nonimmune hydrops fetalis OMIM:266200
Myopathy, Lactic Acidosis, And Sideroblastic Anemia 1
Delayed puberty, Failure to thrive, Pallor, Growth delay OMIM:600462
Mosaic Trisomy 16
Single umbilical artery, Large placenta, Premature birth, Intrauterine growth retardation, Small ... ORPHA:1708
Retinitis Pigmentosa 51
Pallor, Obesity OMIM:613464
Hyperinsulinism Due To Ucp2 Deficiency
Large for gestational age, Pallor ORPHA:276556
Kagami-Ogata Syndrome
Postnatal growth retardation, Large for gestational age, Large placenta, Polyhydramnios, Prematur... ORPHA:254519
X-Linked Sideroblastic Anemia
Pallor ORPHA:75563
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Large for gestational age, Pallor ORPHA:276575
Trichohepatoenteric Syndrome 1
Large placenta, Polyhydramnios, Short stature, Failure to thrive, Abnormalities of placenta or um... OMIM:222470
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Large for gestational age, Pallor ORPHA:276580
Myopathic Ehlers-Danlos Syndrome
Failure to thrive, Pallor ORPHA:536516
Leishmaniasis
Pallor, Skin ulcer, Weight loss ORPHA:507
Spontaneous Periodic Hypothermia
Pallor ORPHA:29822
Hb Bart'S Hydrops Fetalis
Hydrops fetalis, Pallor, Polyhydramnios, Oligohydramnios ORPHA:163596
Primary Myelofibrosis
Purpura, Petechiae, Cachexia, Ecchymosis, Pallor ORPHA:824
Anemia, Sideroblastic, And Spinocerebellar Ataxia
Intrauterine growth retardation, Pallor, Weight loss, Short stature OMIM:301310
Non-Functioning Paraganglioma
Pallor, Weight loss ORPHA:94080
Greenberg Dysplasia
Stillbirth, Large placenta, Hydrops fetalis, Polyhydramnios, Rhizomelia, Disproportionate short-l... OMIM:215140
Restrictive Dermopathy 1
Scaling skin, Short umbilical cord, Stillbirth, Polyhydramnios, Premature birth, Neonatal death, ... OMIM:275210
Dravet Syndrome
Pallor ORPHA:33069
Deafness-Lymphedema-Leukemia Syndrome
Pallor, Weight loss ORPHA:3226
Anemia, Hypochromic Microcytic, With Iron Overload 2
Growth delay, Pallor OMIM:615234
Evans Syndrome
Petechiae, Pallor ORPHA:1959
Beta-Thalassemia
Pallor, Skin ulcer ORPHA:848
Idiopathic Pulmonary Hemosiderosis
Failure to thrive, Pallor ORPHA:99931
Congenital Hyperinsulinism Due To Hnf4A Deficiency
Large for gestational age, Pallor, Increased body weight ORPHA:263455
Sepsis In Premature Infants
Purpura, Petechiae, Decreased body weight, Caesarian section, Premature birth, Pallor, Small for ... ORPHA:90051
Myopathy, Mitochondrial, And Ataxia
Short stature, Pallor, Growth delay OMIM:617675
Megaloblastic Anemia Due To Dihydrofolate Reductase Deficiency
Pallor OMIM:613839
Dominant Beta-Thalassemia
Delayed puberty, Skin ulcer, Growth delay, Failure to thrive in infancy, Pallor ORPHA:231226
Congenital Dyserythropoietic Anemia Type Iii
Short stature, Pallor ORPHA:98870
Kcnq2-Related Epileptic Encephalopathy
Pallor, Facial erythema ORPHA:439218
Acquired Idiopathic Sideroblastic Anemia
Pallor ORPHA:75564
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Postnatal growth retardation, Large for gestational age, Large placenta, Polyhydramnios, Redundan... ORPHA:96334
Beta-Thalassemia Major
Delayed puberty, Skin ulcer, Growth delay, Failure to thrive in infancy, Pallor ORPHA:231214
Irida Syndrome
Pallor ORPHA:209981
Hereditary Folate Malabsorption
Failure to thrive, Pallor ORPHA:90045
Meckel Syndrome, Type 1
Single umbilical artery, Occipital encephalocele, Large placenta, Breech presentation, Anencephal... OMIM:249000
6-Pyruvoyl-Tetrahydropterin Synthase Deficiency
Pallor ORPHA:13
Drug-Induced Autoimmune Hemolytic Anemia
Pallor ORPHA:90037
Hereditary Spherocytosis
Growth delay, Pallor, Skin ulcer ORPHA:822
Cold Agglutinin Disease
Pallor ORPHA:56425
Diamond-Blackfan Anemia 1
Spina bifida occulta, Short stature, Failure to thrive, Premature birth, Intrauterine growth reta... OMIM:105650
Imerslund-Gräsbeck Syndrome
Failure to thrive, Pallor, Weight loss ORPHA:35858
Rheumatic Fever
Pallor, Erythema ORPHA:3099
Mixed-Type Autoimmune Hemolytic Anemia
Pallor ORPHA:90036
Severe Congenital Hypochromic Anemia With Ringed Sideroblasts
Growth delay, Pallor ORPHA:300298
Fanconi Anemia, Complementation Group C
Intrauterine growth retardation, Anemic pallor, Small for gestational age, Short stature OMIM:227645
Sporadic Pheochromocytoma/Secreting Paraganglioma
Pallor, Weight loss ORPHA:276621
American Trypanosomiasis
Pallor ORPHA:3386
Beta-Ketothiolase Deficiency
Pallor, Weight loss ORPHA:134
Fumarase Deficiency
Failure to thrive, Bilateral fetal pyelectasis, Polyhydramnios, Pallor OMIM:606812
Esophageal Atresia
Polyhydramnios, Growth delay, Absence of stomach bubble on fetal sonography, Failure to thrive in... ORPHA:1199
Severe Combined Immunodeficiency Due To Complete Rag1/2 Deficiency
Failure to thrive, Pallor ORPHA:331206
Retinitis Pigmentosa 75
Pallor OMIM:617023
Myelofibrosis
Purpura, Pallor OMIM:254450
Tay-Sachs Disease
Pallor OMIM:272800
Beckwith-Wiedemann Syndrome
Subchorionic septal cyst, Large for gestational age, Large placenta, Polyhydramnios, Redundant sk... ORPHA:116
Cone-Rod Dystrophy 8
Pallor OMIM:605549
3-Hydroxy-3-Methylglutaric Aciduria
Pallor, Weight loss ORPHA:20
Autoimmune Hemolytic Anemia, Warm Type
Pallor ORPHA:90033
Anemia, Sideroblastic, 1
Anemic pallor OMIM:300751
Beta-Thalassemia Intermedia
Pallor, Skin ulcer ORPHA:231222
Pearson Marrow-Pancreas Syndrome
Hydrops fetalis, Failure to thrive, Pallor, Small for gestational age, Erythema OMIM:557000
Hereditary Pheochromocytoma-Paraganglioma
Pallor, Weight loss ORPHA:29072
Degcags Syndrome
Single umbilical artery, Polyhydramnios, Breech presentation, Failure to thrive, Premature birth,... OMIM:619488
Fructose-1,6-Bisphosphatase Deficiency
Pallor ORPHA:348
Senior-Loken Syndrome 8
Pallor OMIM:616307
Methylmalonic Aciduria And Homocystinuria, Cblc Type
Failure to thrive, Pallor, Small for gestational age OMIM:277400
Fanconi Anemia, Complementation Group E
Short stature, Anemic pallor, Small for gestational age OMIM:600901
Systemic Mastocytosis With Associated Hematologic Neoplasm
Pallor, Weight loss ORPHA:98849
Prolactinoma
Delayed puberty, Pallor ORPHA:2965
Plummer-Vinson Syndrome
Pallor ORPHA:54028
Childhood Absence Epilepsy
Pallor ORPHA:64280
Incontinentia Pigmenti
Short stature, Pallor, Erythema OMIM:308300
Sheehan Syndrome
Pallor, Dry skin, Obesity ORPHA:91355
3-Hydroxy-3-Methylglutaryl-Coa Lyase Deficiency
Pallor OMIM:246450
Fanconi Anemia, Complementation Group A
Short stature, Anemic pallor, Small for gestational age OMIM:227650
Waldenström Macroglobulinemia
Purpura, Pallor ORPHA:33226
Non-Functioning Pituitary Adenoma
Pallor ORPHA:91349
Letterer-Siwe Disease
Pallor OMIM:246400
Alternating Hemiplegia Of Childhood
Failure to thrive, Pallor ORPHA:2131
Diamond-Blackfan Anemia
Short stature, Growth delay, Nonimmune hydrops fetalis, Pallor, Small for gestational age ORPHA:124
Adenohypophysitis
Pallor ORPHA:95512
Generalized Juvenile Polyposis/Juvenile Polyposis Coli
Growth delay, Anemic pallor ORPHA:329971
Panhypophysitis
Pallor ORPHA:95513
Elliptocytosis 1
Pallor OMIM:611804
Pituitary Apoplexy
Pallor ORPHA:95613
Aregenerative Anemia
Pallor ORPHA:101096
Neuroblastoma
Anemic pallor, Weight loss ORPHA:635
Tsh-Secreting Pituitary Adenoma
Delayed puberty, Pallor, Weight loss ORPHA:91347
Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema
Pallor OMIM:194380
Anemia, Nonspherocytic Hemolytic, Due To G6Pd Deficiency
Pallor OMIM:300908
Refractory Anemia With Excess Blasts
Anemic pallor ORPHA:86839
Histiocytoid Cardiomyopathy
Failure to thrive, Pallor ORPHA:137675
Fanconi Anemia, Complementation Group D2
Short stature, Anemic pallor, Small for gestational age OMIM:227646
Idiopathic Hypereosinophilic Syndrome
Failure to thrive, Pallor ORPHA:3260
Autosomal Recessive Malignant Osteopetrosis
Growth delay, Pallor ORPHA:667
Infection-Related Hemolytic Uremic Syndrome
Pallor ORPHA:544482
Multiple Endocrine Neoplasia Type 2
Pallor ORPHA:653
Von Hippel-Lindau Disease
Pallor ORPHA:892
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 3
Pallor OMIM:253280
Goodpasture Syndrome
Pallor, Weight loss OMIM:233450
Congenital Total Pulmonary Venous Return Anomaly
Pallor, Low 5-minute APGAR score, Low 1-minute APGAR score ORPHA:99125
Intellectual Developmental Disorder, X-Linked, Syndromic, Cabezas Type
Delayed puberty, Abdominal obesity, Striae distensae, Short stature OMIM:300354
X-Linked Intellectual Disability, Cabezas Type
Short stature, Cachexia, Obesity ORPHA:85293

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cul4b

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cul4b.

No publications found that use IMPC mice or data for Cul4b.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Cul4btm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Cul4btm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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