Gene: Bbs5

Name
Bardet-Biedl syndrome 5 (human)
MGI ID
MGI:1919819
Synonyms
1700049I01Rik 2700023J09Rik
Viability
Homozygous - Viable
Other links
View data by physiological system
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
increased hemoglobin content Bbs5tm1b(EUCOMM)Wtsi HOM postnatal 1.63×10-09
increased total body fat amount Bbs5tm1b(EUCOMM)Wtsi HOM postnatal 0.00
increased lymphocyte cell number Bbs5tm1b(EUCOMM)Wtsi HOM postnatal 9.78×10-06
decreased respiratory quotient Bbs5tm1b(EUCOMM)Wtsi HOM postnatal 1.99×10-08
decreased heart weight Bbs5tm1b(EUCOMM)Wtsi HOM postnatal 6.41×10-05
decreased lean body mass Bbs5tm1b(EUCOMM)Wtsi HOM postnatal 0.00
increased circulating alanine transaminase level Bbs5tm1b(EUCOMM)Wtsi HOM postnatal 1.40×10-05
increased fasted circulating glucose level Bbs5tm1b(EUCOMM)Wtsi HOM postnatal 5.47×10-14
thrombocytopenia Bbs5tm1b(EUCOMM)Wtsi HOM postnatal 4.32×10-07
increased circulating aspartate transaminase level Bbs5tm1b(EUCOMM)Wtsi HOM postnatal 1.98×10-06
decreased spleen weight Bbs5tm1b(EUCOMM)Wtsi HOM postnatal 2.87×10-06
decreased grip strength Bbs5tm1b(EUCOMM)Wtsi HOM postnatal 2.46×10-18
increased mean corpuscular volume Bbs5tm1b(EUCOMM)Wtsi HOM postnatal 4.67×10-10
decreased bone mineral content Bbs5tm1b(EUCOMM)Wtsi HOM postnatal 0.00
abnormal heart left ventricle morphology Bbs5tm1b(EUCOMM)Wtsi HOM postnatal 1.01×10-08
increased circulating alkaline phosphatase level Bbs5tm1b(EUCOMM)Wtsi HOM postnatal 9.33×10-06
abnormal gait Bbs5tm1b(EUCOMM)Wtsi HOM postnatal 3.20×10-09
decreased bone mineral density Bbs5tm1b(EUCOMM)Wtsi HOM postnatal 1.01×10-08
short tibia Bbs5tm1b(EUCOMM)Wtsi HOM postnatal 3.86×10-39
increased leukocyte cell number Bbs5tm1b(EUCOMM)Wtsi HOM postnatal 7.98×10-07
impaired glucose tolerance Bbs5tm1b(EUCOMM)Wtsi HOM postnatal 1.08×10-06
increased circulating glucose level Bbs5tm1b(EUCOMM)Wtsi HOM postnatal 1.61×10-06
decreased heart rate variability Bbs5tm1b(EUCOMM)Wtsi HOM postnatal 1.43×10-05
abnormal behavior Bbs5tm1b(EUCOMM)Wtsi HOM postnatal 6.44×10-05
increased hematocrit Bbs5tm1b(EUCOMM)Wtsi HOM postnatal 2.76×10-06

Download data as:  TSV  XLS

Filtered by: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No  (2/584)  (1/4) N/A
Aorta 4 No N/A
Bone 4 No N/A
Brain 4 No  (4/4)  Wholemount images
Brainstem 4 No N/A
Brown adipose tissue 4 No N/A
Cartilage tissue 4 No  (1/4) N/A
Cerebellum 4 No N/A
Cerebral cortex 4 No N/A
Esophagus 4 No  (7/415) N/A
Eye 4 No N/A
Gall bladder 4 No N/A
Heart 4 No N/A
Hippocampus 4 No N/A
Hypothalamus 4 No  (1/4) N/A
Kidney 4 No  (18/584) N/A
Large intestine 4 No  (10/584) N/A
Liver 4 No N/A
Lower urinary tract 4 No N/A
Lung 4 No N/A
Lymph node 4 No N/A
Mammary gland 4 No N/A
Olfactory lobe 4 No N/A
Oral epithelium 4 No N/A
Ovary 4 No  (1/584) N/A
Oviduct 4 No N/A
Pancreas 4 No  (5/584) N/A
Parathyroid gland 4 No N/A
Peripheral nervous system 4 No N/A
Peyer's patch 4 No N/A
Pituitary gland 4 No N/A
Prostate gland 4 No  (12/584)  (1/4) N/A
Skeletal muscle 4 No N/A
Skin 4 No N/A
Small intestine 4 No  (9/584) N/A
Spinal cord 4 No  (4/4)  Wholemount images
Spleen 4 No  (2/584) N/A
Stomach 4 No  (12/584)  (1/4) N/A
Striatum 4 No N/A
Testis 4 No  (2/584)  (2/4)  Wholemount images
Thymus 4 No N/A
Thyroid gland 4 No  (15/584) N/A
Trachea 4 No  (1/4) N/A
Uterus 4 No N/A
Vascular system 4 No  (1/4) N/A
White adipose tissue 4 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 1  (6/485)  (2/2) N/A
Ear 1  (1/485) N/A
Embryo 1  (1/485)  (2/2) N/A
Eye 1  (1/485) N/A
Foot 1  (1/485) N/A
Forebrain 1  (1/485) N/A
Forelimb 1  (1/485) N/A
Hand 1  (1/485) N/A
Head 1  (5/485)  (2/2) N/A
Heart 1  (1/485) N/A
Hindbrain 1  (6/485)  (2/2) N/A
Hindlimb 1  (1/485) N/A
Liver 1  (1/485) N/A
Lung 1  (1/485) N/A
Mandibular process 1  (1/485) N/A
Maxillary process 1  (1/485) N/A
Midbrain 1  (1/485) N/A
Oral cavity 1  (1/485) N/A
Skin 1  (1/485) N/A
Tail 1  (1/485) N/A
Tail somite 1  (1/485) N/A

 Associated Images

X-ray: XRay Images Lateral Orientation
12 Images
X-ray: XRay Images Dorso Ventral
16 Images
Echo: M-Mode Images
28 Images
Embryo LacZ: LacZ images wholemount
8 Images
Adult LacZ: LacZ Images Wholemount
4 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
8 Images
X-ray: XRay Images Skull Lateral Orientation
2 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Bbs5tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Bbs5tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Bbs5tm1c(EUCOMM)Wtsi Wild type floxed exon (post-Flp) Mice
Bbs5tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Bbs5tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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