Not currently registered for phenotyping at IMPC
Phenotyping is currently not planned for a knockout strain of this gene.
Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
Phenotyping is currently not planned for a knockout strain of this gene.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Lin9 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Triglyceride Storage Disease, Type Ii | Obesity | OMIM:190430 | |
Bardet-Biedl Syndrome 14 | Obesity | OMIM:615991 | |
Obesity | Increased waist to hip ratio, Obesity | OMIM:601665 | |
Maturity-Onset Diabetes Of The Young, Type 11 | Obesity, Overweight | OMIM:613375 | |
Spermatogenic Failure, X-Linked, 1 | Obesity | OMIM:305700 | |
Hypoinsulinemic Hypoglycemia With Hemihypertrophy | Large for gestational age, Truncal obesity | OMIM:240900 | |
Abdominal Obesity-Metabolic Syndrome 1 | Abdominal obesity | OMIM:605552 | |
Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2 | Abdominal obesity | OMIM:605572 | |
Macrosomia With Microphthalmia, Lethal | Large for gestational age | OMIM:248110 | |
Prader-Willi Syndrome (Type 2) | Truncal obesity | DECIPHER:53 | |
Prader-Willi syndrome (Type 1) | Truncal obesity | DECIPHER:14 | |
Mental Retardation, Truncal Obesity, Retinal Dystrophy, And Micropenis Syndrome | Childhood-onset truncal obesity, Truncal obesity | OMIM:610156 | |
Bardet-Biedl Syndrome 11 | Obesity | OMIM:615988 | |
Thumb Stiffness-Brachydactyly-Intellectual Disability Syndrome | Obesity | ORPHA:1078 | |
Dysplasia Epiphysealis Hemimelica | Overgrowth | OMIM:127800 | |
Macrosomia Adiposa Congenita | Large for gestational age, Obesity | OMIM:248100 | |
Bardet-Biedl Syndrome 13 | Obesity | OMIM:615990 | |
Ank3-Related Intellectual Disability-Sleep Disturbance Syndrome | Large for gestational age | ORPHA:356996 | |
Summitt Syndrome | Obesity | OMIM:272350 | |
Intellectual Developmental Disorder, X-Linked 97 | Obesity | OMIM:300803 | |
Pituitary Hormone Deficiency, Combined Or Isolated, 7 | Abdominal obesity, Truncal obesity | OMIM:618160 | |
Bardet-Biedl Syndrome 12 | Obesity | OMIM:615989 | |
Hyperinsulinemic Hypoglycemia, Familial, 1 | Large for gestational age | OMIM:256450 | |
Hypoinsulinemic Hypoglycemia And Body Hemihypertrophy | Large for gestational age, Truncal obesity | ORPHA:293964 | |
Hyperinsulinemic Hypoglycemia, Familial, 2 | Large for gestational age | OMIM:601820 | |
Body Mass Index Quantitative Trait Locus 20 | Obesity, Tall stature | OMIM:618406 | |
Bardet-Biedl Syndrome 18 | Obesity | OMIM:615995 | |
Narcolepsy Type 1 | Obesity | ORPHA:2073 | |
Prolactin Deficiency With Obesity And Enlarged Testes | Obesity | OMIM:264120 | |
Cortisone Reductase Deficiency 2 | Obesity | OMIM:614662 | |
Mitochondrial Complex Iv Deficiency, Nuclear Type 14 | Obesity | OMIM:619058 | |
Ankylosing Vertebral Hyperostosis With Tylosis | Obesity | ORPHA:2206 | |
Prader-Willi Habitus, Osteopenia, And Camptodactyly | Obesity | OMIM:264010 | |
Bardet-Biedl Syndrome 10 | Obesity | OMIM:615987 | |
Carcinoma Of Esophagus | Obesity, Weight loss | ORPHA:70482 | |
Obesity-Hypoventilation Syndrome | Obesity | OMIM:257500 | |
Hernández-Aguirre Negrete Syndrome | Obesity | ORPHA:2139 | |
Microduplication Xp11.22P11.23 Syndrome | Obesity | ORPHA:217377 | |
Obesity Due To Melanocortin 4 Receptor Deficiency | Obesity, Childhood-onset truncal obesity | ORPHA:71529 | |
Central Precocious Puberty | Increased body weight, Obesity, Overgrowth | ORPHA:759 | |
Bardet-Biedl Syndrome 19 | Obesity | OMIM:615996 | |
Polycystic Ovary Syndrome 1 | Obesity | OMIM:184700 | |
Hyperostosis Frontalis Interna | Obesity | OMIM:144800 | |
Bardet-Biedl Syndrome 22 | Large for gestational age, Obesity | OMIM:617119 | |
Hypothyroidism, Central, With Testicular Enlargement | Overweight | OMIM:300888 | |
Obesity-Colitis-Hypothyroidism-Cardiac Hypertrophy-Developmental Delay Syndrome | Obesity | ORPHA:88643 | |
Halothane Hepatitis | Obesity | OMIM:234350 | |
Obesity, Hyperphagia, And Developmental Delay | Obesity | OMIM:613886 | |
Hypogonadotropic Hypogonadism 27 Without Anosmia | Obesity | OMIM:619755 | |
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency | Obesity | ORPHA:329249 | |
Cortisone Reductase Deficiency 1 | Obesity | OMIM:604931 | |
Hepatic Veno-Occlusive Disease | Increased body weight | ORPHA:890 | |
Nephronophthisis 15 | Obesity | OMIM:614845 | |
Retinal Dystrophy And Obesity | Obesity | OMIM:616188 | |
Bardet-Biedl Syndrome 8 | Obesity | OMIM:615985 | |
Narcolepsy 7 | Obesity | OMIM:614250 | |
Hypothyroidism, Congenital, Nongoitrous, 6 | Increased body weight, Increased body mass index | OMIM:614450 | |
Coenzyme Q10 Deficiency, Primary, 2 | Obesity | OMIM:614651 | |
Abdominal Obesity-Metabolic Syndrome 3 | Abdominal obesity, Truncal obesity | OMIM:615812 | |
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome | Increased body weight | ORPHA:276608 | |
Acth-Independent Macronodular Adrenal Hyperplasia 2 | Abdominal obesity, Increased body weight | OMIM:615954 | |
Pseudohypoparathyroidism, Type Ib | Obesity | OMIM:603233 | |
Thyroid Hormone Resistance, Generalized, Autosomal Recessive | Increased body weight, Small for gestational age | OMIM:274300 | |
Body Mass Index Quantitative Trait Locus 19 | Obesity | OMIM:617885 | |
Blue Diaper Syndrome | Increased body weight | ORPHA:94086 | |
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Hypermethylation | Large for gestational age, Overgrowth, Small for gestational age | ORPHA:254534 | |
Proprotein Convertase 1/3 Deficiency | Obesity | OMIM:600955 | |
Smith-Magenis Syndrome | Increased body weight | OMIM:182290 | |
Intellectual Developmental Disorder, X-Linked, Syndromic, Nascimento Type | Increased body weight | OMIM:300860 | |
Wilson Disease | Increased body weight, Weight loss, Failure to thrive | ORPHA:905 | |
Hyperinsulinism Due To Hnf4A Deficiency | Large for gestational age, Increased body weight | ORPHA:263455 | |
Pruritic Urticarial Papules And Plaques Of Pregnancy | Increased body weight | ORPHA:64745 | |
Pigmented Nodular Adrenocortical Disease, Primary, 4 | Increased body weight | OMIM:615830 | |
Insulinoma | Increased body weight | ORPHA:97279 | |
Sotos Syndrome | Increased body weight, Overgrowth, Tall stature | OMIM:117550 | |
Adrenocortical Carcinoma | Increased body weight, Weight loss | ORPHA:1501 | |
Cushing Syndrome Due To Macronodular Adrenal Hyperplasia | Abdominal obesity, Increased body weight | ORPHA:189427 | |
Magel2-Related Prader-Willi-Like Syndrome | Abdominal obesity, Increased body weight, Failure to thrive | ORPHA:398069 | |
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency | Increased body weight, Failure to thrive | ORPHA:264580 | |
Primary Pigmented Nodular Adrenocortical Disease | Abdominal obesity, Increased body weight | ORPHA:189439 | |
Glycogen Storage Disease Due To Liver And Muscle Phosphorylase Kinase Deficiency | Increased body weight | ORPHA:79240 | |
Insulin-Resistance Syndrome Type B | Increased body weight, Weight loss, Decreased body weight, Abnormality of body weight | ORPHA:2298 | |
Hellp Syndrome | Increased body weight | ORPHA:244242 | |
Cushing Disease | Abdominal obesity, Increased body weight, Truncal obesity | ORPHA:96253 | |
Cushing Syndrome Due To Ectopic Acth Secretion | Abdominal obesity, Increased body weight, Weight loss, Truncal obesity | ORPHA:99889 | |
Carney Complex | Abdominal obesity, Increased body weight, Tall stature | ORPHA:1359 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Lin9tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Lin9tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
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