Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

SEC24 homolog C, COPII coat complex component

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Sec24c mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Sec24c by orthology or direct annotation.

Disease Similarity of
Matching phenotypes Source
22Q11.2 Deletion Syndrome

The table below shows human diseases predicted to be associated to Sec24c by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
22Q11.2 Deletion Syndrome


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Sec24c

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Sec24c.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Murine SEC24D can substitute functionally for SEC24C during embryonic development. Scientific reports (October 2021) Sec24ctm1a(EUCOMM)Wtsi PMC8548507
The COPII cargo adapter SEC24C is essential for neuronal homeostasis. The Journal of clinical investigation (June 2018) Sec24ctm1c(EUCOMM)Wtsi PMC6063503
Mammalian COPII coat component SEC24C is required for embryonic development in mice. The Journal of biological chemistry (July 2014) Sec24ctm1c(EUCOMM)Wtsi Sec24ctm1a(EUCOMM)Wtsi Sec24ctm1d(EUCOMM)Wtsi PMC4110293

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Sec24ctm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Sec24ctm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Sec24ctm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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