Iars2 | isoleucine-tRNA synthetase 2, mitochondrial

GeneMGI:1919586Synonyms: 2010002H18Rik

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Vision/eye Hematopoietic system Mortality/aging

17 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:5Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

preweaning lethality, complete penetrance3 supporting datasetsIars2em1(IMPC)TcphomozygoteEarly adultN/A * 
embryonic lethality prior to organogenesis1 supporting datasetIars2em1(IMPC)TcphomozygoteE9.5N/A * 
prenatal lethality prior to heart atrial septation1 supporting datasetIars2em1(IMPC)TcphomozygoteE15.5N/A * 
abnormal eye morphology1 supporting datasetIars2em1(IMPC)TcpheterozygoteEarly adultN/A * 
increased hematocrit1 supporting datasetIars2em1(IMPC)TcpheterozygoteEarly adult1.7x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
Download data as:  










* This parameter was manually assessed for significance.
Download data as:  

lacZ Expression

Associated images

Loading...

Histopathology

IMPC related publications

Loading...

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

Iars2em1(IMPC)TcpExon Deletionmouse
Iars2tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Iars2tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Iars2tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter