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Gene: Palld MGI:1919583

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
palladin, cytoskeletal associated protein
Synonyms:
2410003B16Rik

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Palld mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Palld by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Pancreatic Cancer, Susceptibility To, 1
OMIM:606856
Familial Pancreatic Carcinoma
ORPHA:1333

The table below shows human diseases predicted to be associated to Palld by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Type II lissencephaly, Neural tube defect OMIM:615041
Spina Bifida-Hypospadias Syndrome
Spinal dysraphism, Spina bifida ORPHA:3176
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Acalvaria
Abnormality of neuronal migration, Holoprosencephaly, Hydrocephalus, Spina bifida ORPHA:945
Subependymal Nodular Heterotopia
Occipital encephalocele, Polymicrogyria, Myelomeningocele, Abnormality of neuronal migration, Nas... ORPHA:101030
Frontal Encephalocele
Hydrocephalus, Encephalocele, Spina bifida ORPHA:1931
Joubert Syndrome 15
Exencephaly OMIM:614464
Ophthalmoplegia, External, And Myopia
Spina bifida OMIM:311000
Neural Tube Defects, Susceptibility To
Myelomeningocele, Spina bifida occulta, Anencephaly, Hydrocephalus OMIM:182940
Hemihyperplasia, Isolated
Myelomeningocele OMIM:235000
Chiari Malformation Type Ii
Cervical myelopathy, Myelomeningocele, Hydrocephalus, Spina bifida, Gray matter heterotopia OMIM:207950
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Anencephaly, Spina bifida ORPHA:2476
Hypertelorism-Hypospadias-Polysyndactyly Syndrome
Abnormal cortical gyration, Polymicrogyria, Encephalocele, Exencephaly, Abnormality of neuronal m... ORPHA:2211
Camptodactyly With Muscular Hypoplasia, Skeletal Dysplasia, And Abnormal Palmar Creases
Spina bifida OMIM:211960
Schisis Association
Anencephaly, Encephalocele, Spina bifida ORPHA:63862
Craniorachischisis
Spinal dysraphism, Myelomeningocele, Sirenomelia, Cervical spina bifida, Anencephaly ORPHA:63260
Nevus Comedonicus Syndrome
Spina bifida occulta, Spina bifida ORPHA:64754
Caudal Duplication
Myelomeningocele, Spina bifida ORPHA:1756
Wildervanck Syndrome
Meningocele ORPHA:3456
Aminopterin/Methotrexate Embryofetopathy
Spinal dysraphism, Encephalocele, Hydrocephalus, Meningocele, Holoprosencephaly, Anencephaly ORPHA:1908
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Muscle-Eye-Brain Disease
Meningocele, Holoprosencephaly, Hydrocephalus ORPHA:588
Humero-Radial Synostosis
Meningocele ORPHA:3265
Meckel Syndrome, Type 4
Hydrocephalus, Meningocele, Anencephaly, Encephalocele OMIM:611134
Meckel Syndrome, Type 2
Meningocele, Anencephaly, Encephalocele OMIM:603194
Thoraco-Abdominal Enteric Duplication
Meningocele ORPHA:1759
Acropectorovertebral Dysplasia
Spina bifida ORPHA:957
Intellectual Developmental Disorder, Autosomal Dominant 72
Spina bifida OMIM:620439
Isolated Klippel-Feil Syndrome
Spina bifida ORPHA:2345
Neurocutaneous Melanocytosis
Abnormality of neuronal migration, Meningocele ORPHA:2481
Isolated Posterior Meningocele
Hydrocephalus, Lipomyelomeningocele, Meningocele, Occipital meningocele, Neural tube defect ORPHA:268810
Iniencephaly
Spinal dysraphism, Myelomeningocele, Encephalocele, Hydrocephalus, Spina bifida, Holoprosencephal... ORPHA:63259
Amish Lethal Microcephaly
Spina bifida, Lissencephaly ORPHA:99742
Anophthalmia Plus Syndrome
Spina bifida ORPHA:1104
Camptodactyly Syndrome, Guadalajara Type 1
Spina bifida ORPHA:1327
Czeizel-Losonci Syndrome
Myelomeningocele, Spina bifida occulta, Hydrocephalus, Spina bifida ORPHA:2437
Sirenomelia
Sirenomelia, Spina bifida ORPHA:3169
Waardenburg Syndrome Type 1
Meningocele, Spina bifida ORPHA:894
Sacral Defect With Anterior Meningocele
Myelomeningocele, Myeloschisis, Hydrocephalus, Meningocele, Dermal sinus tract OMIM:600145
Triploidy
Meningocele, Holoprosencephaly, Hydrocephalus ORPHA:3376
Fountain Syndrome
Spina bifida occulta, Spina bifida ORPHA:3219
Joubert Syndrome 14
Hydrocephalus, Meningocele, Encephalocele OMIM:614424
Autosomal Recessive Spondylocostal Dysostosis
Spina bifida occulta, Meningocele, Umbilical hernia ORPHA:2311
Cleft Lip/Palate-Deafness-Sacral Lipoma Syndrome
Meningocele ORPHA:2003
Cerebrocostomandibular Syndrome
Myelomeningocele, Hydranencephaly, Spina bifida, Meningocele ORPHA:1393
Neu-Laxova Syndrome 2
Spina bifida, Lissencephaly OMIM:616038
Pelvis-Shoulder Dysplasia
Hydranencephaly, Hydrocephalus, Spina bifida ORPHA:2839
Fliedner-Zweier Syndrome
Meningocele OMIM:620511
Neu-Laxova Syndrome
Abnormal cortical gyration, Polymicrogyria, Abnormality of neuronal migration, Spina bifida, Pach... ORPHA:2671
Lung Agenesis-Heart Defect-Thumb Anomalies Syndrome
Spina bifida ORPHA:1120
Hepatic Fibrosis-Renal Cysts-Intellectual Disability Syndrome
Meningocele ORPHA:2031
Acromelic Frontonasal Dysplasia
Meningocele, Encephalocele ORPHA:1827
Aprosencephaly Syndrome
Aprosencephaly, Anencephaly OMIM:207770
Curry-Jones Syndrome
Occipital meningocele, Lipomyelomeningocele, Polymicrogyria OMIM:601707
Pagod Syndrome
Abnormality of neuronal migration, Meningocele, Encephalocele, Spina bifida ORPHA:991
Lateral Meningocele Syndrome
Meningocele, Umbilical hernia ORPHA:2789
Lateral Meningocele Syndrome
Meningocele, Hydrocephalus, Umbilical hernia OMIM:130720
Lumbar Syndrome
Myelomeningocele, Spina bifida ORPHA:83628
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Anencephaly, Hydrocephalus, Occipital meningocele, Polymicrogyria OMIM:616546
Chromosome 17P13.1 Deletion Syndrome
Hydrocephalus, Spina bifida, Umbilical hernia OMIM:613776
Trisomy 20P
Spina bifida, Umbilical hernia ORPHA:261318
Limb Body Wall Complex
Myelomeningocele, Encephalocele, Short umbilical cord, Hydrocephalus, Spina bifida, Spina bifida ... ORPHA:2369
Joubert Syndrome With Jeune Asphyxiating Thoracic Dystrophy
Meningocele, Occipital encephalocele ORPHA:397715
Waardenburg Syndrome, Type 1
Myelomeningocele, Spina bifida OMIM:193500
Vacterl With Hydrocephalus
Aqueductal stenosis, Hydrocephalus, Spina bifida ORPHA:3412
Cloacal Exstrophy
Myelomeningocele, Spina bifida ORPHA:93929
Trisomy 18
Holoprosencephaly, Anencephaly, Spina bifida ORPHA:3380
Phakomatosis Pigmentokeratotica
Spina bifida ORPHA:2874
Mosaic Trisomy 9
Spina bifida ORPHA:99776
Orofaciodigital Syndrome Vi
Periventricular nodular heterotopia, Occipital meningocele, Polymicrogyria OMIM:277170
Aicardi Syndrome
Pachygyria, Gray matter heterotopia, Spina bifida, Polymicrogyria OMIM:304050
Nail-Patella Syndrome
Spina bifida OMIM:161200
Lathosterolosis
Meningocele ORPHA:46059
Focal Dermal Hypoplasia
Spina bifida, Umbilical hernia ORPHA:2092
Fibular Hemimelia
Spina bifida ORPHA:93323
Hallermann-Streiff Syndrome
Spina bifida OMIM:234100
Neu-Laxova Syndrome 1
Hydranencephaly, Small placenta, Short umbilical cord, Neonatal death, Spina bifida, Stillbirth, ... OMIM:256520
Basal Cell Nevus Syndrome 1
Hydrocephalus, Spina bifida OMIM:109400
Holoprosencephaly 7
Alobar holoprosencephaly, Semilobar holoprosencephaly, Hydrocephalus, Holoprosencephaly, Occipita... OMIM:610828
Knobloch Syndrome 1
Spina bifida occulta, Occipital encephalocele, Occipital meningocele, Polymicrogyria OMIM:267750
Jacobsen Syndrome
Pachygyria, Spina bifida ORPHA:2308
Phocomelia, Schinzel Type
Meningocele ORPHA:2879
Arima Syndrome
Gray matter heterotopia, Occipital meningocele OMIM:243910
Autosomal Dominant Palmoplantar Keratoderma And Congenital Alopecia
Meningocele ORPHA:1010
Intellectual Disability-Cardiac Anomalies-Short Stature-Joint Laxity Syndrome
Spina bifida ORPHA:508498
Neurofibromatosis, Type I
Aqueductal stenosis, Hydrocephalus, Spina bifida OMIM:162200
22Q11.2 Deletion Syndrome
Hydrocephalus, Meningocele, Spina bifida, Umbilical hernia ORPHA:567
Campomelic Dysplasia
Hydrocephalus, Spinal dysraphism, Spina bifida OMIM:114290
Koolen-De Vries Syndrome Due To A Point Mutation
Hydrocephalus, Spina bifida ORPHA:363965
17Q21.31 Microdeletion Syndrome
Hydrocephalus, Spina bifida ORPHA:363958
Fanconi Anemia
Hydrocephalus, Spina bifida, Umbilical hernia ORPHA:84
Thrombocytopenia-Absent Radius Syndrome
Spina bifida OMIM:274000
Holoprosencephaly 9
Abnormal cortical gyration, Alobar holoprosencephaly, Hydrocephalus, Holoprosencephaly, Occipital... OMIM:610829
Rubinstein-Taybi Syndrome 1
Spina bifida occulta, Spina bifida OMIM:180849
Cutis Laxa, Autosomal Recessive, Type Ib
Spina bifida, Neonatal death OMIM:614437
Neurodevelopmental Disorder With Dysmorphic Facies And Thin Corpus Callosum
Spina bifida OMIM:619480
Vater/Vacterl Association
Patent urachus, Occipital encephalocele, Spina bifida OMIM:192350
Marfan Syndrome
Meningocele ORPHA:558
Otopalatodigital Syndrome, Type Ii
Stillbirth, Hydrocephalus, Spina bifida, Umbilical hernia OMIM:304120
Femoral-Facial Syndrome
Encephalocele, Spina bifida OMIM:134780
Exstrophy-Epispadias Complex
Hydrocephalus, Spina bifida ORPHA:322
Ulna And Fibula, Absence Of, With Severe Limb Deficiency
Occipital meningocele OMIM:276820
Pancreatic Cancer, Susceptibility To, 1
OMIM:606856
Familial Pancreatic Carcinoma
ORPHA:1333

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Palld

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Palld.

No publications found that use IMPC mice or data for Palld.

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MGI Allele Allele Type Produced
Palldtm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Palldtm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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