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Gene: Brf1 MGI:1919558

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
Synonyms:
GTF3B,  TAF3C,  2510002F24Rik,  TAFIII90,  TFIIIB90

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Legacy Phenotype Associated Images
Brf1tm1a(EUCOMM)Wtsi
WT, Female, WTSI
Brf1tm1a(EUCOMM)Wtsi
WT, Female, WTSI
Brf1tm1a(EUCOMM)Wtsi
WT, Female, WTSI
Brf1tm1a(EUCOMM)Wtsi
WT, Female, WTSI
Brf1tm1a(EUCOMM)Wtsi
WT, Female, WTSI

View all 31 images

Human diseases caused by Brf1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Brf1 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Cerebellofaciodental Syndrome
OMIM:616202
Cerebellar-Facial-Dental Syndrome
ORPHA:444072

The table below shows human diseases predicted to be associated to Brf1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Cerebellofaciodental Syndrome
OMIM:616202
Cerebellar-Facial-Dental Syndrome
ORPHA:444072

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Brf1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Brf1.

No publications found that use IMPC mice or data for Brf1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Brf1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Brf1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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