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Genes Phenotypes Help, News, Blog

Gene: Cda MGI:1919519

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
cytidine deaminase
Synonyms:
2210401N16Rik

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Cda mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cda by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
N Syndrome
Leukemia, Neoplasm, Abnormality of chromosome stability OMIM:310465
Mosaic Variegated Aneuploidy Syndrome 4
Abnormality of chromosome stability OMIM:620153
Fanconi Anemia, Complementation Group G
Leukemia, Abnormality of chromosome stability, Myelodysplasia OMIM:614082
Fraxf Syndrome
Folate-dependent fragile site at Xq28 ORPHA:100974
Intrauterine Growth Retardation With Increased Mitomycin C Sensitivity
Abnormality of chromosome stability OMIM:600546
Ataxia-Telangiectasia
Abnormality of chromosome stability, Neoplasm, Elevated hepatic transaminase ORPHA:100
Fanconi Anemia, Complementation Group D1
Chromosomal breakage induced by crosslinking agents, Acute myeloid leukemia, T-cell acute lymphob... OMIM:605724
Nijmegen Breakage Syndrome-Like Disorder
Chromosomal breakage induced by ionizing radiation OMIM:613078
Microcephaly, Growth Restriction, And Increased Sister Chromatid Exchange 2
Increased susceptibility to spontaneous sister chromatid exchange OMIM:618097
Immunodeficiency 54
Lymphoproliferative disorder, Chromosome breakage OMIM:609981
Scleroderma, Familial Progressive
Abnormality of chromosome stability, Chromosome breakage OMIM:181750
Fanconi Anemia, Complementation Group T
Chromosomal breakage induced by crosslinking agents, Acute myeloid leukemia OMIM:616435
Transcobalamin Deficiency
Abnormality of chromosome stability ORPHA:859
Fanconi Anemia, Complementation Group S
Ovarian neoplasm, Breast carcinoma, Chromosome breakage, Ovarian carcinoma OMIM:617883
Fanconi Anemia, Complementation Group J
Chromosomal breakage induced by crosslinking agents OMIM:609054
Radial-Renal Syndrome
Chromosome breakage OMIM:179280
Fanconi Anemia, Complementation Group N
Chromosomal breakage induced by crosslinking agents, Nephroblastoma, Neuroblastoma, Medulloblastoma OMIM:610832
Mitochondrial Complex Iv Deficiency, Nuclear Type 16
Chromosomal breakage induced by crosslinking agents OMIM:619060
Fragile X Syndrome
Folate-dependent fragile site at Xq28 OMIM:300624
Fanconi Anemia, Complementation Group O
Chromosome breakage OMIM:613390
Lig4 Syndrome
Lymphoma, Abnormality of chromosome stability, Acute leukemia ORPHA:99812
Fragile X Syndrome
Folate-dependent fragile site at Xq28 ORPHA:908
Fanconi Anemia, Complementation Group E
Leukemia, Chromosomal breakage induced by crosslinking agents, Deficient excision of UV-induced p... OMIM:600901
Fanconi Anemia, Complementation Group V
Chromosomal breakage induced by crosslinking agents OMIM:617243
Fanconi Anemia, Complementation Group A
Leukemia, Chromosomal breakage induced by crosslinking agents, Deficient excision of UV-induced p... OMIM:227650
Bloom Syndrome
Leukemia, Chromosome breakage, Lymphoma, Abnormality of chromosome stability, Squamous cell carci... OMIM:210900
Fanconi Anemia, Complementation Group Q
Chromosome breakage OMIM:615272
X-Linked Intellectual Disability-Acromegaly-Hyperactivity Syndrome
Folate-dependent fragile site at Xq28 ORPHA:85327
Fanconi Anemia, Complementation Group P
Squamous cell carcinoma, Chromosomal breakage induced by crosslinking agents OMIM:613951
Fanconi Anemia, Complementation Group C
Leukemia, Chromosomal breakage induced by crosslinking agents, Deficient excision of UV-induced p... OMIM:227645
Nijmegen Breakage Syndrome
Neoplasm, Acute leukemia, Glioma, B-cell lymphoma, Lymphoma, Abnormality of chromosome stability,... ORPHA:647
Bone Marrow Failure Syndrome 3
Chromosome breakage, Acute myeloid leukemia OMIM:617052
Fanconi Anemia, Complementation Group U
Chromosome breakage OMIM:617247
Icf Syndrome
Abnormality of chromosome stability ORPHA:2268
Fanconi Anemia, Complementation Group I
Chromosomal breakage induced by crosslinking agents OMIM:609053
Fanconi Anemia, Complementation Group R
Chromosomal breakage induced by crosslinking agents OMIM:617244
Fanconi Anemia, Complementation Group B
Abnormality of chromosome stability OMIM:300514
Fanconi Anemia, Complementation Group D2
Leukemia, Chromosomal breakage induced by crosslinking agents, Deficient excision of UV-induced p... OMIM:227646
Dyskeratosis Congenita, Autosomal Recessive 8
Chromosomal breakage induced by crosslinking agents OMIM:620133
Fanconi Anemia, Complementation Group L
Chromosomal breakage induced by crosslinking agents, Chromosome breakage OMIM:614083
Cartilage-Hair Hypoplasia
Abnormality of chromosome stability ORPHA:175
Fanconi Anemia, Complementation Group F
Chromosomal breakage induced by crosslinking agents OMIM:603467
Revesz Syndrome
Abnormality of chromosome stability OMIM:268130
Meningioma
Intracranial meningioma, Neoplasm of the anterior pituitary, Spinal meningioma, Chromosomal break... ORPHA:2495
Fanconi Anemia
Abnormality of chromosome stability, Neoplasm, Myelodysplasia ORPHA:84
Riddle Syndrome
Chromosomal breakage induced by ionizing radiation ORPHA:420741

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cda

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cda.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Cytidine deaminase deficiency in mice enhances genetic instability but limits the number of chemically induced colon tumors. Cancer letters (December 2022) Cdatm1c(EUCOMM)Wtsi Cdatm1a(EUCOMM)Wtsi Cdatm1d(EUCOMM)Wtsi 36496104
Cdan1 Is Essential for Primitive Erythropoiesis. Frontiers in physiology (June 2021) Cdan1tm1a(KOMP)Wtsi PMC8255688
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Cdan1em1(IMPC)Wtsi PMC7263671

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Cdatm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Cdatm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Cdatm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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