The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
Legacy Phenotype Associated Images
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Scaf11 by phenotypic similarity.
||Kyphosis, Increased bone mineral density, Scoliosis, Abnormal form of the vertebral bodies, Scler...||ORPHA:2777|
|Sacral Agenesis With Vertebral Anomalies||
||Abnormal vertebral morphology, Absence of the sacrum||OMIM:615709|
|Ankylosing Vertebral Hyperostosis With Tylosis||
|Familial Scheuermann Disease||
||Kyphosis, Abnormal form of the vertebral bodies||ORPHA:3135|
|Spondylocostal Dysostosis 6, Autosomal Recessive||
||Spinal canal stenosis, Butterfly vertebrae, Hemivertebrae, Scoliosis, Cervical kyphosis||OMIM:616566|
|Endosteal Hyperostosis, Autosomal Dominant||
||Metacarpal diaphyseal endosteal sclerosis, Metatarsal diaphyseal endosteal sclerosis, Clavicular ...||OMIM:144750|
||Diaphyseal sclerosis, Hyperostosis, Craniofacial osteosclerosis||OMIM:126250|
||Increased bone mineral density, Hyperostosis||OMIM:155950|
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Scaf11.
There are 4 publications which use IMPC produced mice or data.
|Title||Journal||IMPC Allele||PubMed ID|
|A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation.||G3 (Bethesda, Md.) (June 2020)||Scaf11em1(IMPC)Wtsi||PMC7263671|
|High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation.||Nature immunology (December 2019)||Scaf11em1(IMPC)Wtsi||PMC7338221|
|Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis.||Nature communications (August 2019)||Scaf11em1Wtsi||PMC6671969|
|Mouse screen reveals multiple new genes underlying mouse and human hearing loss.||PLoS biology (April 2019)||Scaf11em1Wtsi||PMC6459510|
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
This service may be affected by the Covid-19 pandemic. See how
|MGI Allele||Allele Type||Produced|
|Scaf11tm1a(EUCOMM)Wtsi||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors, ES Cells|
|Scaf11tm1e(EUCOMM)Wtsi||Targeted, non-conditional allele||ES Cells|
|Scaf11tm1(KOMP)Vlcg||Reporter-tagged deletion allele (with selection cassette)||ES Cells|