Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
abnormal response to tactile stimuli | Tmem68tm1a(EUCOMM)Wtsi | HOM | Early adult | 3.68×10-12 | ||
abnormal glucose homeostasis | Tmem68tm1a(EUCOMM)Wtsi | HOM | Early adult | 4.39×10-06 | ||
increased circulating aspartate transaminase level | Tmem68tm1a(EUCOMM)Wtsi | HOM | Early adult | 8.06×10-05 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Tmem68 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Pentosuria | Abnormal circulating carbohydrate concentration, Abnormality of circulating enzyme level | ORPHA:2843 | |
Glycogen Storage Disease Vi | Elevated hepatic transaminase, Hepatomegaly, Hypertriglyceridemia, Failure to thrive in infancy, ... | OMIM:232700 | |
Glycogen Storage Disease Ixc | Elevated hepatic transaminase, Hepatomegaly, Hypertriglyceridemia, Postnatal growth retardation, ... | OMIM:613027 | |
Late-Onset Familial Hypoaldosteronism | Postnatal growth retardation, Failure to thrive, Elevated serum 11-deoxycortisol, Abnormal circul... | ORPHA:556037 | |
Congenital Bile Acid Synthesis Defect Type 2 | Elevated hepatic transaminase, Giant cell hepatitis, Hepatomegaly, Failure to thrive, Postnatal g... | ORPHA:79303 | |
Early-Onset Familial Hypoaldosteronism | Postnatal growth retardation, Failure to thrive, Elevated serum 11-deoxycortisol, Abnormal circul... | ORPHA:556030 |
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tmem68.
There are 1 publication which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
Identification of an alternative triglyceride biosynthesis pathway. | Nature (August 2023) | Tmem68tm1a(EUCOMM)Wtsi | PMC10482677 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Tmem68tm47153(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
Tmem68tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | ES Cells |
Tmem68tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
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