Gene Summary

RNA binding protein with multiple splicing 2

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal bone structure Rbpms2em1(IMPC)J HOM Early adult 2.22×10-11
decreased bone mineral content Rbpms2em1(IMPC)J HOM Early adult 3.60×10-32
decreased bone mineral density Rbpms2em1(IMPC)J HOM Early adult 9.92×10-28
female infertility Rbpms2em1(IMPC)J HOM Early adult 0.00
increased total body fat amount Rbpms2em1(IMPC)J HOM Early adult 1.10×10-11
decreased lean body mass Rbpms2em1(IMPC)J HOM Early adult 5.12×10-11

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.


XRay Images Skull Lateral Orientation

11 Images


XRay Images Whole Body Lateral Orientation

11 Images


XRay Images Forepaw

11 Images


XRay Images Whole Body Dorso Ventral

11 Images


XRay Images Skull Dorso Ventral Orientation

11 Images

Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

8 Images

Human diseases caused by Rbpms2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Rbpms2 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Premature Ovarian Failure 2B
Female infertility, Premature ovarian insufficiency, Osteoporosis, Primary amenorrhea OMIM:300604
Oocyte/Zygote/Embryo Maturation Arrest 9
Oocyte arrest at metaphase I, Female infertility OMIM:619011
Oocyte/Zygote/Embryo Maturation Arrest 4
Oocyte arrest at metaphase I, Female infertility OMIM:617743
Oocyte/Zygote/Embryo Maturation Arrest 2
Oocyte arrest at metaphase I, Female infertility OMIM:616780
Oocyte/Zygote/Embryo Maturation Arrest 5
Female infertility, Lack of oocyte pronucleus formation OMIM:617996
Premature Ovarian Failure 19
Irregular menstruation, Female infertility, Premature ovarian insufficiency, Secondary amenorrhea OMIM:619245
Infertility, Increased bone mineral density OMIM:166450
Oocyte/Zygote/Embryo Maturation Arrest 8
Female infertility OMIM:619009
Oocyte/Zygote/Embryo Maturation Arrest 13
Female infertility OMIM:620154
Oocyte/Zygote/Embryo Maturation Arrest 12
Female infertility OMIM:619697
Oocyte/Zygote/Embryo Maturation Arrest 10
Female infertility OMIM:619176
Hydatidiform Mole, Recurrent, 3
Female infertility OMIM:618431
Hydatidiform Mole, Recurrent, 4
Female infertility OMIM:618432
Progesterone Resistance
Female infertility OMIM:264080
Oocyte/Zygote/Embryo Maturation Arrest 6
Female infertility OMIM:618353
Oocyte/Zygote/Embryo Maturation Arrest 11
Female infertility OMIM:619643
Oocyte/Zygote/Embryo Maturation Arrest 7
Female infertility OMIM:618550
Oocyte/Zygote/Embryo Maturation Arrest 15
Female infertility OMIM:616814
Oocyte/Zygote/Embryo Maturation Arrest 1
Female infertility OMIM:615774
Oocyte/Zygote/Embryo Maturation Arrest 3
Female infertility OMIM:617712
Oligomenorrhea, Female infertility, Menorrhagia OMIM:615555
Female Infertility Due To Oocyte Meiotic Arrest
Abnormal meiosis, Female infertility, Abnormal spermatogenesis, Oocyte arrest at metaphase I ORPHA:488191
Osteosclerosis-Ichthyosis-Premature Ovarian Failure Syndrome
Increased bone mineral density, Premature ovarian insufficiency ORPHA:75325
Familial Hyperprolactinemia
Oligomenorrhea, Osteoporosis, Osteopenia, Infertility, Female hypogonadism, Menorrhagia, Amenorrhea ORPHA:397685
Asherman Syndrome
Oligomenorrhea, Dysmenorrhea, Decreased fertility in females, Metrorrhagia, Infertility, Abnormal... ORPHA:137686
Premature Ovarian Failure 13
Oligomenorrhea, Female infertility, Amenorrhea OMIM:617442
Melorheostosis, Isolated
Increased bone mineral density, Hyperostosis OMIM:155950
Premature Ovarian Failure 6
Premature ovarian insufficiency, Primary amenorrhea, Female infertility, Streak ovary, Secondary ... OMIM:612310
Premature Ovarian Failure 20
Female infertility, Secondary amenorrhea OMIM:619938
Hypophosphatemic Rickets, Autosomal Recessive, 1
Craniosynostosis, Rickets, Hypophosphatemic rickets, Increased bone mineral density OMIM:241520
Aromatase Deficiency
Eunuchoid habitus, Primary amenorrhea, Osteoporosis, Osteopenia, Hypergonadotropic hypogonadism, ... ORPHA:91
Ring Chromosome Y Syndrome
Female infertility, Azoospermia, Streak ovary, Male infertility, Abnormal spermatogenesis, Male h... ORPHA:261529
Muscular Dystrophy, Congenital Hearing Loss, And Ovarian Insufficiency Syndrome
Female infertility, Premature ovarian insufficiency, Failure to thrive OMIM:619518
Ciliary Dyskinesia, Primary, 37
Female infertility OMIM:617577
Ovarian Dysgenesis 3
Female infertility, Primary amenorrhea OMIM:614324
Blepharophimosis, Ptosis, And Epicanthus Inversus
Irregular menstruation, Female infertility, Premature ovarian insufficiency, Amenorrhea OMIM:110100
Primary Ciliary Dyskinesia
Female infertility, Abnormal sperm motility, Male infertility ORPHA:244
Turner Syndrome
Premature ovarian insufficiency, Reduced bone mineral density, Primary amenorrhea, Failure to thr... ORPHA:881
Mosaic Monosomy X
Premature ovarian insufficiency, Reduced bone mineral density, Primary amenorrhea, Failure to thr... ORPHA:99228
Monosomy X
Premature ovarian insufficiency, Reduced bone mineral density, Primary amenorrhea, Failure to thr... ORPHA:99226
Turner Syndrome Due To Structural X Chromosome Anomalies
Premature ovarian insufficiency, Reduced bone mineral density, Primary amenorrhea, Failure to thr... ORPHA:99413
Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Plus
Oligomenorrhea, Premature ovarian insufficiency, Hypergonadotropic hypogonadism, Decreased fertil... ORPHA:572333


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Rbpms2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Rbpms2.

No publications found that use IMPC mice or data for Rbpms2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Rbpms2tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Rbpms2em1(IMPC)J Exon Deletion Mice
Rbpms2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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