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Genes Phenotypes Help, News, Blog

Gene: Myh14 MGI:1919210

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Gene Summary

Name:
myosin, heavy polypeptide 14
Synonyms:
NMHC II-C,  2400004E04Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

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Viewing: all phenotypes
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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

14 Images

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X-ray

XRay Images Skull Lateral Orientation

12 Images

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X-ray

XRay Images Whole Body Dorso Ventral

15 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

15 Images

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X-ray

XRay Images Forepaw

14 Images

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DSS Histology

Images

2 Images

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Legacy Phenotype Associated Images
Myh14tm1a(EUCOMM)Wtsi
WT, Male, WTSI
Myh14tm1a(EUCOMM)Wtsi
WT, Male, WTSI
Myh14tm1a(EUCOMM)Wtsi
WT, Male, WTSI
Myh14tm1a(EUCOMM)Wtsi
WT, Male, WTSI
Myh14tm1a(EUCOMM)Wtsi
WT, Male, WTSI

View all 85 images

Myh14tm1a(EUCOMM)Wtsi
right eye, HOM, Male, WTSI
Myh14tm1a(EUCOMM)Wtsi
Fused cornea and lens, HOM, Female, WTSI
Myh14tm1a(EUCOMM)Wtsi
persistence of hyaloid vascular system, HOM, Male, WTSI
Myh14tm1a(EUCOMM)Wtsi
persistence of hyaloid vascular system, HOM, Male, WTSI

Human diseases caused by Myh14 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Myh14 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Peripheral Neuropathy-Myopathy-Hoarseness-Hearing Loss Syndrome
ORPHA:397744
Deafness, Autosomal Dominant 4A
OMIM:600652
Peripheral Neuropathy, Myopathy, Hoarseness, And Hearing Loss
OMIM:614369

The table below shows human diseases predicted to be associated to Myh14 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Reticulum Cell Sarcoma
Neoplasm, Sarcoma OMIM:267730
Ewing Sarcoma
Ewing sarcoma OMIM:612219
Juvenile Myelomonocytic Leukemia
Juvenile myelomonocytic leukemia OMIM:607785
Lymphoblastic Leukemia, Acute, With Lymphomatous Features
Acute lymphoblastic leukemia, Lymphoma, T-cell acute lymphoblastic leukemias OMIM:247640
Sarcoma, Synovial
Synovial sarcoma OMIM:300813
Alveolar Soft Part Sarcoma
Alveolar soft part sarcoma OMIM:606243
Leukemia, Acute Monocytic
Acute monocytic leukemia OMIM:151380
Leukemia, Acute, X-Linked
Acute leukemia OMIM:308960
Leukemia, Acute Myeloid
Acute myeloid leukemia OMIM:601626
Leukemia, Acute Lymphoblastic
Acute lymphoblastic leukemia OMIM:613065
Melanoma-Pancreatic Cancer Syndrome
Pancreatic adenocarcinoma, Oropharyngeal squamous cell carcinoma, Squamous cell carcinoma, Melano... OMIM:606719
Nut Midline Carcinoma
Oropharyngeal squamous cell carcinoma, Pancreatoblastoma, Squamous cell carcinoma, Neoplasm, Panc... ORPHA:443167
Leukemia, Chronic Lymphocytic
Chronic lymphatic leukemia OMIM:151400
Leukemia, Chronic Lymphocytic, Susceptibility To, 2
Chronic lymphatic leukemia OMIM:109543
Myelocytic Leukemia-Like Syndrome, Familial, Chronic
Chronic myelogenous leukemia OMIM:600080
Peripheral Neuropathy-Myopathy-Hoarseness-Hearing Loss Syndrome
ORPHA:397744
Deafness, Autosomal Dominant 4A
OMIM:600652
Peripheral Neuropathy, Myopathy, Hoarseness, And Hearing Loss
OMIM:614369

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Myh14

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Myh14.

There are 4 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Myh14tm1a(EUCOMM)Wtsi PMC7263671
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Myh14tm1a(EUCOMM)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Myh14tm1a(EUCOMM)Wtsi PMC6459510
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Myh14tm1a(EUCOMM)Wtsi Myh14tm1a(EUCOMM)Wtsi PMC5827107

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Myh14tm40498(L1L2_gt0) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Myh14tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Myh14tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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