Tmem106b | transmembrane protein 106B

GeneMGI:1919150Synonyms: 6430519M21Rik, 5830455K21Rik, +1 more

Physiological systems

21 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Growth/size/body region Vision/eye Skeleton

16 No significant impact

3 Not tested

Gene metrics:7Significant phenotypes
4Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues

Phenotypes

increased circulating alkaline phosphatase level1 supporting datasetTmem106btm2b(KOMP)WtsihomozygoteEarly adult9.24x10-62 
enlarged epididymis1 supporting datasetTmem106btm2b(KOMP)WtsihomozygoteEarly adultN/A * 
decreased body length2 supporting datasetsTmem106btm2b(KOMP)WtsihomozygoteEarly adult1.91x10-6 
increased bone mineral content1 supporting datasetTmem106btm2b(KOMP)WtsihomozygoteEarly adult6.42x10-5 
abnormal retina inner nuclear layer morphology1 supporting datasetTmem106bem1(IMPC)BayhomozygoteEarly adult2.85x10-7 
decreased total retina thickness1 supporting datasetTmem106bem1(IMPC)BayhomozygoteEarly adult5.69x10-6 
abnormal epididymis morphology1 supporting datasetTmem106btm2b(KOMP)WtsihomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
Download data as:  










* Does not have a P-value assigned because it was manually marked as significant.
Download data as:  

lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Tmem106bem1(IMPC)BayExon Deletionmouse
Tmem106btm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Tmem106btm1e(KOMP)WtsiTargeted, non-conditional allelees cell
Tmem106btm2a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Tmem106btm2b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse

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