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Gene: Pla2g4e MGI:1919144

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Gene Summary

Name:
phospholipase A2, group IVE
Synonyms:
Pla2epsilon,  2310026J01Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased grip strength Pla2g4etm2b(EUCOMM)Hmgu HOM Early adult 4.24×10-05
abnormal coat appearance Pla2g4etm2b(EUCOMM)Hmgu HOM   Early adult 1.96×10-06

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Eye Morphology

VIP of right fundus

15 Images

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Eye Morphology

VIP of right eye

15 Images

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X-ray

XRay Images Forepaw

9 Images

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Eye Morphology

VIP of left fundus

15 Images

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X-ray

XRay Images Whole Body Dorso Ventral

9 Images

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Eye Morphology

VIP of left eye

14 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

9 Images

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X-ray

XRay Images Whole Body Lateral Orientation

9 Images

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X-ray

XRay Images Skull Lateral Orientation

9 Images

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Human diseases caused by Pla2g4e mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Pla2g4e by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Acne Inversa, Familial, 3
Chronic furunculosis, Perifolliculitis, Acne inversa, Recurrent cutaneous abscess formation OMIM:613737
Immunodeficiency 51
Pneumonia, Folliculitis, Chronic mucocutaneous candidiasis, Eczematoid dermatitis, Cutaneous absc... OMIM:613953
Familial Reactive Perforating Collagenosis
Hyperkeratotic papule, Inflammatory abnormality of the skin, Crusting erythematous dermatitis, Pe... ORPHA:79147
Chilblain Lupus 2
Chilblains OMIM:614415
Acne Inversa, Familial, 2, With Or Without Dowling-Degos Disease
Acne inversa, Chronic furunculosis, Perifolliculitis, Follicular hyperkeratosis, Recurrent cutane... OMIM:613736
Verrucous Hemangioma
Hyperkeratotic papule, Inflammatory abnormality of the skin ORPHA:464318
Benign Cephalic Histiocytosis
Inflammatory abnormality of the skin, Skin rash ORPHA:157997
Kerion Celsi
Inflammatory abnormality of the skin, Recurrent skin infections, Recurrent cutaneous abscess form... ORPHA:499
Epidermolytic Hyperkeratosis 2A, Autosomal Dominant
Palmoplantar keratoderma, Generalized hyperkeratosis, Cobblestone-like hyperkeratosis, Palmoplant... OMIM:620150
Ichthyosis Hystrix Of Curth-Macklin
Diffuse palmoplantar hyperkeratosis, Recurrent skin infections, Hyperkeratosis ORPHA:79503
Paget Disease, Extramammary
Eczematoid dermatitis OMIM:167300
Ulerythema Ophryogenesis
Acne, Hyperkeratotic papule, Contact dermatitis, Follicular hyperkeratosis ORPHA:3406
Proteasome-Associated Autoinflammatory Syndrome 5
Skin rash, Hypertriglyceridemia OMIM:619175
Mal De Meleda
Nonepidermolytic palmoplantar hyperkeratosis, Inflammatory abnormality of the skin, Palmoplantar ... ORPHA:87503
Chilblain Lupus
Discoid lupus rash, Inflammatory abnormality of the skin, Malar rash, Skin rash, Pruritis on hand... ORPHA:90280
Intellectual Developmental Disorder, Fra12A Type
Hyperkeratosis, Erythroderma OMIM:136630
Pityriasis Rubra Pilaris
Subungual hyperkeratosis, Palmoplantar keratoderma, Eczematoid dermatitis, Pustule, Erythroderma,... ORPHA:2897
Ichthyosis, Congenital, Autosomal Recessive 10
Erythroderma, Orthokeratotic hyperkeratosis, Palmoplantar keratoderma, Hyperkeratosis OMIM:615024
Erythrokeratodermia Variabilis Et Progressiva 6
Parakeratosis, Pruritus, Superficial dermal perivascular inflammatory infiltrate OMIM:618531
Erythrokeratodermia Variabilis Et Progressiva 1
Patchy palmoplantar hyperkeratosis, Erythroderma, Generalized hyperkeratosis OMIM:133200
Erythema Nodosum, Familial
Erythema nodosum OMIM:132990
Inflammatory Bowel Disease 28, Autosomal Recessive
Folliculitis, Pyoderma, Crohn's disease, Perianal abscess, Enterocolitis, Colitis OMIM:613148
Peeling Skin Syndrome 6
Atopic dermatitis, Parakeratosis, Pruritus, Orthokeratosis OMIM:618084
Pruritic Urticarial Papules And Plaques Of Pregnancy
Pruritus on foot, Eczematoid dermatitis, Pruritis on breast, Parakeratosis, Pruritis on hand, Pru... ORPHA:64745
Ichthyosis With Erythrokeratoderma
Palmoplantar keratoderma, Diffuse palmoplantar hyperkeratosis, Parakeratosis, Palmoplantar hyperk... OMIM:620507
Ige Responsiveness, Atopic
Allergic rhinitis, Eczematoid dermatitis OMIM:147050
Seborrhea-Like Dermatitis With Psoriasiform Elements
Seborrheic dermatitis, Hyperkeratosis OMIM:610227
Psoriasis 2
Parakeratosis, Psoriasiform dermatitis, Hyperkeratosis OMIM:602723
Chronic Actinic Dermatitis
Allergic rhinitis, Eczematoid dermatitis, Erythroderma, Late onset atopic dermatitis, Pruritus ORPHA:330064
Protoporphyria, Erythropoietic, 1
Pruritus, Eczematoid dermatitis, Hypertriglyceridemia OMIM:177000
Interstitial Granulomatous Dermatitis With Arthritis
Inflammatory abnormality of the skin, Pruritus, Rheumatoid arthritis ORPHA:79099
Iga Pemphigus
Cutaneous abscess, Neutrophilic infiltration of the skin, Pustule, Acantholysis, Pruritus, Ulcera... ORPHA:555905
Inflammatory Bowel Disease 25, Autosomal Recessive
Perianal abscess, Folliculitis, Enterocolitis, Pancolitis OMIM:612567
Pemphigus Foliaceus
Psoriasiform dermatitis, Crusting erythematous dermatitis, Pustule, Erythroderma, Acantholysis, P... ORPHA:79481
Yao Syndrome
Uveitis, Inflammatory abnormality of the skin, Skin rash, Keratoconjunctivitis sicca, Arthritis, ... OMIM:617321
Vexas Syndrome
Arteritis, Inflammatory abnormality of the skin, Neutrophilic infiltration of the skin, Nasal cho... OMIM:301054

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Pla2g4e

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Pla2g4e.

No publications found that use IMPC mice or data for Pla2g4e.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Pla2g4etm2e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Pla2g4etm2b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice
Pla2g4etm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Pla2g4etm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Pla2g4etm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Pla2g4etm39423(L1L2_gt0) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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