Gene Summary

Name:
threonyl-tRNA synthetase 2, mitochondrial (putative)
Synonyms:
2610024N01Rik,  Tarsl1

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
embryonic lethality prior to organogenesis Tars2tm1b(EUCOMM)Hmgu HOM   E9.5 0.00
preweaning lethality, complete penetrance Tars2tm1b(EUCOMM)Hmgu HOM   Early adult 0.00
embryonic lethality prior to tooth bud stage Tars2tm1b(EUCOMM)Hmgu HOM   E12.5 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

No Adult expression data was found for this gene.

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Heart atrium N/A heterozygote Ambiguous
Axial skeleton N/A heterozygote Ambiguous
Brain N/A heterozygote Ambiguous
Central nervous system ganglion N/A heterozygote Ambiguous
Cranium N/A heterozygote Ambiguous
Dorsal root ganglion N/A heterozygote Ambiguous
Ear N/A heterozygote Ambiguous
Embryo N/A heterozygote Ambiguous
Outer ear N/A heterozygote Ambiguous
Eye N/A heterozygote Ambiguous
Femur pre-cartilage condensation N/A heterozygote Ambiguous
Footplate N/A heterozygote Ambiguous
Forearm N/A heterozygote Ambiguous
Forebrain N/A heterozygote Ambiguous
Forelimb N/A heterozygote Ambiguous
Fronto-nasal process N/A heterozygote Ambiguous
Gut N/A heterozygote Ambiguous
Handplate N/A heterozygote Ambiguous
Head mesenchyme N/A heterozygote Ambiguous
Head N/A heterozygote Ambiguous
Heart ventricle N/A heterozygote Ambiguous
Heart N/A heterozygote Ambiguous
Hindbrain N/A heterozygote Ambiguous
Hindlimb N/A heterozygote Ambiguous
Humerus pre-cartilage condensation N/A heterozygote Ambiguous
Inner ear N/A heterozygote Ambiguous
Intestine N/A heterozygote Ambiguous
Liver N/A heterozygote Ambiguous
Lower leg N/A heterozygote Ambiguous
Lung N/A heterozygote Ambiguous
Mandibular process N/A heterozygote Ambiguous
Maxillary process N/A heterozygote Ambiguous
Meckel's cartilage N/A heterozygote Ambiguous
Mesonephros of female N/A heterozygote Ambiguous
Mesonephros of male N/A heterozygote Ambiguous
Metanephros N/A heterozygote Ambiguous
Midbrain N/A heterozygote Ambiguous
Nasal septum N/A heterozygote Ambiguous
Nose N/A heterozygote Ambiguous
Notochord N/A heterozygote Ambiguous
Oral cavity N/A heterozygote Ambiguous
Outflow tract N/A heterozygote Ambiguous
Pancreas N/A heterozygote Ambiguous
N/A heterozygote Ambiguous
Pharynx N/A heterozygote Ambiguous
Chorioallantoic placenta N/A heterozygote Ambiguous
Radius-ulna pre-cartilage condensation N/A heterozygote Ambiguous
Rib pre-cartilage condensation N/A heterozygote Ambiguous
Skeleton N/A heterozygote Ambiguous
Skin N/A heterozygote Ambiguous
Spinal cord N/A heterozygote Ambiguous
Stomach N/A heterozygote Ambiguous
Tail somite N/A heterozygote Ambiguous
Tail N/A heterozygote Ambiguous
Thoracic vertebral cartilage condensation N/A heterozygote Ambiguous
Tongue N/A heterozygote Ambiguous
Trachea N/A heterozygote Ambiguous
Trunk mesenchyme N/A heterozygote Ambiguous
Umbilical artery embryonic part N/A heterozygote Ambiguous
Umbilical vein embryonic part N/A heterozygote Ambiguous
Upper arm N/A heterozygote Ambiguous
Upper leg N/A heterozygote Ambiguous
Urinary system N/A heterozygote Ambiguous
Vibrissa N/A heterozygote Ambiguous

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)

Background staining occurs in wild type mice and embryos at an incidental rate.

Background staining occurs in wild type embryos at a measurable rate.

Anatomy Background staining in controls(WT)
atrium 1.72% (1 of 58)
axial skeleton 1.69% (1 of 59)
brain 1.26% (6 of 476)
central nervous system ganglion 0.0%
cranium 1.79% (1 of 56)
dorsal root ganglion 1.75% (1 of 57)
ear 0.0%
embryo 0.21% (1 of 476)
external ear 1.43% (1 of 70)
eye 0.21% (1 of 483)
femur pre-cartilage condensation 2.04% (1 of 49)
footplate 0.21% (1 of 470)
forearm 0.36% (1 of 277)
forebrain 0.21% (1 of 468)
forelimb 0.21% (1 of 473)
fronto-nasal process 1.75% (1 of 57)
gut 1.79% (1 of 56)
handplate 0.21% (1 of 478)
head 0.86% (4 of 466)
head mesenchyme 1.79% (1 of 56)
heart 0.21% (1 of 481)
heart ventricle 1.89% (1 of 53)
hindbrain 1.27% (6 of 472)
hindlimb 0.22% (1 of 462)
humerus pre-cartilage condensation 0.0%
inner ear 1.85% (1 of 54)
intestine 1.85% (1 of 54)
liver 0.21% (1 of 471)
lower leg 0.35% (1 of 284)
lung 0.21% (1 of 474)
mandibular process 0.22% (1 of 462)
maxillary process 0.21% (1 of 469)
meckel's cartilage 0.0%
mesonephros of female 2.04% (1 of 49)
mesonephros of male 2% (1 of 50)
metanephros 1.85% (1 of 54)
midbrain 0.2% (1 of 488)
nasal septum 1.72% (1 of 58)
nose 1.37% (1 of 73)
notochord 1.75% (1 of 57)
oral cavity 0.0%
outflow tract 1.96% (1 of 51)
pancreas 2% (1 of 50)
pericardium 1.92% (1 of 52)
pharynx 1.85% (1 of 54)
placenta 17.95% (7 of 39)
radius-ulna pre cartilage condensation 1.79% (1 of 56)
rib pre-cartilage condensation 1.82% (1 of 55)
skeleton 1.33% (1 of 75)
skin 0.21% (1 of 468)
spinal cord 1.61% (1 of 62)
stomach 1.96% (1 of 51)
tail 0.21% (1 of 474)
tail somite group 0.21% (1 of 474)
thoracic vertebral cartilage condensation 1.96% (1 of 51)
tongue 2% (1 of 50)
trachea 1.82% (1 of 55)
trunk mesenchyme 1.79% (1 of 56)
umbilical artery embryonic part 1.79% (1 of 56)
umbilical vein embryonic part 1.92% (1 of 52)
upper arm 0.36% (1 of 280)
upper leg 0.35% (1 of 283)
urinary system 1.72% (1 of 58)
vibrissa 1.47% (1 of 68)

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Embryo LacZ

LacZ images wholemount

10 Images

Gross Morphology Embryo E9.5

Images

2 Images

Human diseases caused by Tars2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Tars2 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Combined Oxidative Phosphorylation Deficiency 21
Neonatal death OMIM:615918

The table below shows human diseases predicted to be associated to Tars2 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Combined Oxidative Phosphorylation Deficiency 21
Neonatal death OMIM:615918

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Tars2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tars2.

No publications found that use IMPC mice or data for Tars2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Tars2tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice
Tars2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Tars2tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter