Vwa8 | von Willebrand factor A domain containing 8

GeneMGI:1919008Synonyms: 4932416F07Rik, 1300010F03Rik

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Vision/eye Cardiovascular system

16 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:6Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased circulating potassium level1 supporting datasetVwa8tm1b(EUCOMM)WtsihomozygoteEarly adult5.14x10-7 
abnormal vitreous body morphology1 supporting datasetVwa8tm1b(EUCOMM)WtsihomozygoteEarly adult6.29x10-5 
abnormal retina blood vessel morphology1 supporting datasetVwa8tm1b(EUCOMM)WtsihomozygoteEarly adult4.44x10-5 
abnormal retina morphology1 supporting datasetVwa8tm1b(EUCOMM)WtsihomozygoteEarly adult3.17x10-5 
abnormal retina vasculature morphology1 supporting datasetVwa8tm1b(EUCOMM)WtsihomozygoteEarly adult8.87x10-6 
increased fasting circulating glucose level1 supporting datasetVwa8tm1b(EUCOMM)WtsihomozygoteEarly adult3.03x10-7 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Vwa8tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Vwa8tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Vwa8tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Vwa8tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell
Vwa8tm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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