Tmprss6 | transmembrane serine protease 6
Physiological systems
15 / 24 physiological systems tested
11 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Pigmentation Integument Growth/size/body region Limbs/digits/tail Nervous system Hematopoietic system Behavior/neurological Skeleton Cardiovascular system
4 No significant impact
9 Not tested
Data collections
Gene metrics:22Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
abnormal coat/ hair morphology | 3 supporting datasets | Tmprss6tm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.96x10-8 | ||
increased Ly6C-positive mature NK cell number | 1 supporting dataset | Tmprss6tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.61x10-6 | ||
abnormal coat/hair pigmentation | 6 supporting datasets | Tmprss6tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.66x10-9 | ||
decreased prepulse inhibition | 8 supporting datasets | Tmprss6tm1b(EUCOMM)Wtsi | homozygote | Early adult | 6.04x10-9 | ||
decreased mean corpuscular hemoglobin concentration | 1 supporting dataset | Tmprss6tm1b(EUCOMM)Wtsi | homozygote | Early adult | 7.72x10-6 | ||
increased heart weight | 1 supporting dataset | Tmprss6tm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.95x10-5 | ||
increased circulating calcium level | 1 supporting dataset | Tmprss6tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.82x10-6 | ||
short tibia | 2 supporting datasets | Tmprss6tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.11x10-37 | ||
decreased NK cell number | 1 supporting dataset | Tmprss6tm1b(EUCOMM)Wtsi | homozygote | Early adult | 4.24x10-6 | ||
decreased locomotor activity | 4 supporting datasets | Tmprss6tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.15x10-5 |
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External links
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Tmprss6tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
Tmprss6tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
Tmprss6tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
Tmprss6tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |