Tmprss6 | transmembrane serine protease 6

GeneMGI:1919003Synonyms: 1300008A22Rik, matriptase-2

Physiological systems

15 / 24 physiological systems tested

11 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Pigmentation Integument Growth/size/body region Limbs/digits/tail Nervous system Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

4 No significant impact

9 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Viability data
Body weight measurements
Embryo imaging data
Gene metrics:22Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal coat/ hair morphology3 supporting datasetsTmprss6tm1b(EUCOMM)WtsihomozygoteEarly adult3.96x10-8 
increased Ly6C-positive mature NK cell number1 supporting datasetTmprss6tm1b(EUCOMM)WtsihomozygoteEarly adult2.61x10-6 
abnormal coat/hair pigmentation6 supporting datasetsTmprss6tm1b(EUCOMM)WtsihomozygoteEarly adult2.66x10-9 
decreased prepulse inhibition8 supporting datasetsTmprss6tm1b(EUCOMM)WtsihomozygoteEarly adult6.04x10-9 
decreased mean corpuscular hemoglobin concentration1 supporting datasetTmprss6tm1b(EUCOMM)WtsihomozygoteEarly adult7.72x10-6 
increased heart weight1 supporting datasetTmprss6tm1b(EUCOMM)WtsihomozygoteEarly adult3.95x10-5 
increased circulating calcium level1 supporting datasetTmprss6tm1b(EUCOMM)WtsihomozygoteEarly adult2.82x10-6 
short tibia2 supporting datasetsTmprss6tm1b(EUCOMM)WtsihomozygoteEarly adult2.11x10-37 
decreased NK cell number1 supporting datasetTmprss6tm1b(EUCOMM)WtsihomozygoteEarly adult4.24x10-6 
decreased locomotor activity4 supporting datasetsTmprss6tm1b(EUCOMM)WtsihomozygoteEarly adult1.15x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Tmprss6tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Tmprss6tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Tmprss6tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Tmprss6tm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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