Gene Summary

Name:
nectin cell adhesion molecule 4
Synonyms:
nectin 4,  Prr4,  1200017F15Rik,  Pvrl4

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased exploration in new environment Nectin4em1(IMPC)J HET Early adult 4.29×10-08
decreased body length Nectin4em1(IMPC)J HET   Early adult 7.61×10-05
preweaning lethality, incomplete penetrance Nectin4em1(IMPC)J HOM   Early adult 0.00
decreased grip strength Nectin4em1(IMPC)J HET Early adult 3.22×10-07

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

11 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

11 Images

X-ray

XRay Images Skull Lateral Orientation

11 Images

X-ray

XRay Images Forepaw

11 Images

X-ray

XRay Images Whole Body Dorso Ventral

11 Images

Human diseases caused by Nectin4 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Nectin4 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Ectodermal Dysplasia-Syndactyly Syndrome 1
OMIM:613573

The table below shows human diseases predicted to be associated to Nectin4 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Ectodermal Dysplasia-Syndactyly Syndrome 1
OMIM:613573

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Nectin4

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Nectin4.

No publications found that use IMPC mice or data for Nectin4.

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MGI Allele Allele Type Produced
Nectin4em1(IMPC)J Exon Deletion Mice

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