Gene Summary

Name:
VPS11, CORVET/HOPS core subunit
Synonyms:
1200011A11Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Vps11em1(IMPC)Rbrc HOM   Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Eye Morphology

Images Ophthalmoscopy

3 Images

Eye Morphology

Images Slit Lamp

1 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

Human diseases caused by Vps11 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Vps11 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Dystonia 32
OMIM:619637
Vps11-Related Autosomal Recessive Hypomyelinating Leukodystrophy
ORPHA:466934
Leukodystrophy, Hypomyelinating, 12
OMIM:616683

The table below shows human diseases predicted to be associated to Vps11 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Dystonia 32
OMIM:619637
Vps11-Related Autosomal Recessive Hypomyelinating Leukodystrophy
ORPHA:466934
Leukodystrophy, Hypomyelinating, 12
OMIM:616683

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Vps11

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Vps11.

No publications found that use IMPC mice or data for Vps11.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Vps11tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Vps11tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Vps11tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Vps11tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Vps11em1(IMPC)Rbrc Exon Deletion Mice

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