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Gene: Cic MGI:1918972

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
capicua transcriptional repressor
Synonyms:
1200010B10Rik

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Cic mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Cic by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Intellectual Developmental Disorder, Autosomal Dominant 45
Attention deficit hyperactivity disorder, Hyperactivity OMIM:617600

The table below shows human diseases predicted to be associated to Cic by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Schizophrenia 15
Hyperactivity OMIM:613950
Attention Deficit-Hyperactivity Disorder
Attention deficit hyperactivity disorder, Hyperactivity OMIM:143465
Attention Deficit-Hyperactivity Disorder 8
Attention deficit hyperactivity disorder OMIM:619957
22q13 deletion syndrome (Phelan-Mcdermid syndrome)
Hyperactivity DECIPHER:20
Potocki-Lupski syndrome (17p11.2 duplication syndrome)
Hyperactivity DECIPHER:19
Attention Deficit-Hyperactivity Disorder, Susceptibility To, 7
Attention deficit hyperactivity disorder OMIM:613003
Intellectual Developmental Disorder, Autosomal Recessive 3
Hyperactivity OMIM:608443
Intellectual Developmental Disorder, X-Linked 77
Hyperactivity OMIM:300454
Intellectual Developmental Disorder, Autosomal Dominant 33
Hyperactivity OMIM:616311
Intellectual Developmental Disorder, X-Linked, Syndromic, Houge Type
Attention deficit hyperactivity disorder, Hyperactivity, Impulsivity OMIM:301008
Mucus Inspissation Of Respiratory Tract
Recurrent respiratory infections, Bronchiectasis, Atelectasis OMIM:253240
Emphysema, Hereditary Pulmonary
Chronic bronchitis, Emphysema OMIM:130700
Intellectual Developmental Disorder, X-Linked 72
Hyperactivity OMIM:300271
Intellectual Developmental Disorder, Autosomal Recessive 37
Hyperactivity OMIM:615493
Ank3-Related Intellectual Disability-Sleep Disturbance Syndrome
Hyperactivity ORPHA:356996
Intellectual Disability-Expressive Aphasia-Facial Dysmorphism Syndrome
Hyperactivity ORPHA:436151
Ciliary Dyskinesia, Primary, 29
Recurrent respiratory infections, Bronchiectasis, Atelectasis OMIM:615872
Smith-Magenis syndrome
Hyperactivity DECIPHER:8
Retinitis Pigmentosa, X-Linked, And Sinorespiratory Infections With Or Without Deafness
Recurrent bronchitis, Atelectasis OMIM:300455
Developmental And Epileptic Encephalopathy 43
Attention deficit hyperactivity disorder, Hyperactivity, Impulsivity OMIM:617113
Ciliary Dyskinesia, Primary, 33
Atelectasis, Recurrent lower respiratory tract infections, Recurrent pneumonia, Bronchiectasis, R... OMIM:616726
Hartnup Disorder
Attention deficit hyperactivity disorder, Hyperactivity OMIM:234500
Developmental And Epileptic Encephalopathy 104
Hyperactivity, Agitation OMIM:619970
Hyperlysinemia, Type I
Hyperactivity OMIM:238700
Intellectual Developmental Disorder, X-Linked, Syndromic, Pilorge Type
Hyperactivity OMIM:301076
Ciliary Dyskinesia, Primary, 21
Recurrent pneumonia, Bronchiectasis, Atelectasis OMIM:615294
Ciliary Dyskinesia, Primary, 47, And Lissencephaly
Recurrent respiratory infections, Bronchiectasis, Atelectasis OMIM:619466
Intellectual Developmental Disorder, X-Linked 109
Impulsivity, Hyperactivity, Agitation OMIM:309548
Fraxe Intellectual Disability
Hyperactivity, Impulsivity, Agitation ORPHA:100973
Congenital Lobar Emphysema
Emphysema ORPHA:1928
8p23.1 deletion syndrome
Hyperactivity DECIPHER:39
Intellectual Developmental Disorder, X-Linked 101
Hyperactivity OMIM:300928
Glycine Encephalopathy 1
Hyperactivity, Restlessness, Impulsivity OMIM:605899
Intellectual Developmental Disorder With Epilepsy, Behavioral Abnormalities, And Coarse Facies
Hyperactivity OMIM:619031
Language Delay And Attention Deficit-Hyperactivity Disorder/Cognitive Impairment With Or Without Cardiac Arrhythmia
Attention deficit hyperactivity disorder, Hyperactivity OMIM:617182
Familial Nasal Acilia
Bronchiectasis, Atelectasis, Recurrent upper respiratory tract infections ORPHA:922
Respiratory Distress Syndrome In Premature Infants
Pulmonary edema, Atelectasis OMIM:267450
Bronchopulmonary Dysplasia
Abnormal lung morphology, Pulmonary sequestration, Atelectasis, Emphysema ORPHA:70589
Intellectual Developmental Disorder, Autosomal Dominant 67
Attention deficit hyperactivity disorder, Hyperactivity OMIM:619927
Histidinemia
Hyperactivity ORPHA:2157
Bare Lymphocyte Syndrome, Type I
Recurrent bronchitis, Bronchiolitis, Bronchiectasis, Emphysema OMIM:604571
Birt-Hogg-Dubé Syndrome
Pulmonary sequestration, Pneumothorax, Emphysema ORPHA:122
Acute Interstitial Pneumonia
Reticulonodular pattern on pulmonary HRCT, Atelectasis, Interlobular septal thickening, Pulmonary... ORPHA:79126
Idiopathic Bronchiectasis
Recurrent lower respiratory tract infections, Respiratory tract infection, Bronchiectasis, Emphys... ORPHA:60033
Infant Acute Respiratory Distress Syndrome
Pulmonary edema, Respiratory tract infection, Pneumonia, Atelectasis ORPHA:70587
Cutis Laxa, Neonatal, With Marfanoid Phenotype
Emphysema OMIM:614100
Sarcoidosis, Susceptibility To, 2
Pulmonary fibrosis, Elevated bronchoalveolar lavage fluid lymphocyte proportion, Bronchiectasis, ... OMIM:612387
Plectin-Related Limb-Girdle Muscular Dystrophy R17
Bronchiolitis, Atelectasis, Pulmonary fibrosis ORPHA:254361
Asbestos Intoxication
Atelectasis, Interlobular septal thickening, Pulmonary fibrosis, Pleural thickening, Abnormal pul... ORPHA:2302
Tracheobronchopathia Osteochondroplastica
Recurrent respiratory infections, Bronchitis, Atelectasis, Recurrent pneumonia, Pneumonia ORPHA:3348
Surfactant Metabolism Dysfunction, Pulmonary, 3
Reticular pattern on pulmonary HRCT, Desquamative interstitial pneumonitis, Paraseptal emphysema,... OMIM:610921
Bronchogenic Cyst
Atelectasis, Abnormal pleura morphology, Bronchogenic cyst, Pulmonary cyst, Pneumonia ORPHA:2357
Alpha-1-Antitrypsin Deficiency
Emphysema ORPHA:60
Recurrent Respiratory Papillomatosis
Recurrent pneumonia, Abnormal lung morphology, Atelectasis, Recurrent upper respiratory tract inf... ORPHA:60032
Respiratory Bronchiolitis-Interstitial Lung Disease Syndrome
Hypersensitivity pneumonitis, Chronic bronchitis, Honeycomb lung, Respiratory tract infection, Br... ORPHA:79127
Meconium Aspiration Syndrome
Pneumothorax, Aspiration pneumonia, Atelectasis ORPHA:70588
Epidermodysplasia Verruciformis, Susceptibility To, 4
Emphysema OMIM:618307
Myotubular Myopathy With Abnormal Genital Development
Atelectasis, Neonatal death OMIM:300219
Choreoathetosis And Congenital Hypothyroidism With Or Without Pulmonary Dysfunction
Recurrent respiratory infections, Atelectasis, Pulmonary fibrosis, Elevated bronchoalveolar lavag... OMIM:610978
Primary Ciliary Dyskinesia
Recurrent sinopulmonary infections, Atelectasis, Respiratory tract infection, Pulmonary situs amb... ORPHA:244
Idiopathic Chronic Eosinophilic Pneumonia
Hypersensitivity pneumonitis, Pleural effusion, Atelectasis ORPHA:2902
Waardenburg Syndrome Type 3
Atelectasis ORPHA:896
Ciliary Dyskinesia, Primary, 1
Recurrent bronchitis, Bronchiectasis, Pneumonia, Atelectasis OMIM:244400
Respiratory Infections, Recurrent, And Failure To Thrive With Or Without Diarrhea
Atelectasis, Recurrent lower respiratory tract infections, Bronchiectasis, Abnormal pulmonary int... OMIM:620233
Intellectual Developmental Disorder, Autosomal Dominant 45
Attention deficit hyperactivity disorder, Hyperactivity OMIM:617600
T-Cell Immunodeficiency With Thymic Aplasia
Recurrent bronchopulmonary infections, Recurrent pneumonia, Bronchiectasis, Emphysema OMIM:242700
Autosomal Dominant Hyper-Ige Syndrome
Recurrent respiratory infections, Atelectasis ORPHA:2314
Farber Disease
Nodular pattern on pulmonary HRCT, Atelectasis, Recurrent upper respiratory tract infections ORPHA:333
Whim Syndrome
Atelectasis, Respiratory tract infection, Recurrent pneumonia, Bronchiectasis, Pneumonia, Recurre... ORPHA:51636
Lymphangioleiomyomatosis
Recurrent respiratory infections, Atelectasis, Pulmonary lymphangiomyomatosis, Emphysema, Pneumot... ORPHA:538
Ciliary Dyskinesia, Primary, 20
Recurrent respiratory infections, Atelectasis, Recurrent pneumonia, Bronchiectasis, Pulmonary art... OMIM:615067
Short-Rib Thoracic Dysplasia 12
Pulmonary hypoplasia, Atelectasis, Neonatal death OMIM:269860
Familial Gestational Hyperthyroidism
Hyperactivity, Agitation ORPHA:99819
Cutis Laxa, Autosomal Recessive, Type Ic
Atelectasis, Pulmonary hypoplasia, Peripheral pulmonary artery stenosis, Recurrent pneumonia, Emp... OMIM:613177
B3Galt6-Related Spondylodysplastic Ehlers-Danlos Syndrome
Repeated pneumothoraces, Pulmonary hypoplasia, Atelectasis ORPHA:536467
Laminin Subunit Alpha 2-Related Congenital Muscular Dystrophy
Recurrent lower respiratory tract infections, Atelectasis ORPHA:258
Lujo Hemorrhagic Fever
Atelectasis ORPHA:319213
Fibrosis, Neurodegeneration, And Cerebral Angiomatosis
Recurrent respiratory infections, Atelectasis, Pulmonary fibrosis OMIM:618278
Granulomatous Disease, Chronic, X-Linked
Pleural effusion, Recurrent pneumonia, Atelectasis OMIM:306400
Zygomycosis
Pleural effusion, Pneumothorax, Atelectasis, Acute infectious pneumonia ORPHA:73263
Glycogen Storage Disease Due To Acid Maltase Deficiency
Respiratory tract infection, Atelectasis ORPHA:365
22Q11.2 Deletion Syndrome
Abnormal lung lobation, Atelectasis ORPHA:567
Oculocerebrorenal Syndrome Of Lowe
Recurrent respiratory infections, Atelectasis ORPHA:534
Chand Syndrome
Atelectasis ORPHA:1401
Relapsing Polychondritis
Atelectasis ORPHA:728
Digeorge Syndrome
Recurrent pneumonia, Atelectasis, Recurrent sinusitis OMIM:188400

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cic

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cic.

There are 10 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Postnatal regulation of B-1a cell development and survival by the CIC-PER2-BHLHE41 axis. Cell reports (February 2022) Cictm1c(KOMP)Wtsi 35172136
Capicua regulates the development of adult-born neurons in the hippocampus. Scientific reports (June 2021) Cictm1c(KOMP)Wtsi PMC8175746
Ataxin-1 regulates B cell function and the severity of autoimmune experimental encephalomyelitis. Proceedings of the National Academy of Sciences of the United States of America (September 2020) Cictm1c(KOMP)Wtsi PMC7519225
The Capicua/ETS Translocation Variant 5 Axis Regulates Liver-Resident Memory CD8+ T-Cell Development and the Pathogenesis of Liver Injury. Hepatology (Baltimore, Md.) (April 2019) Cictm1c(KOMP)Wtsi 30810242
CIC protein instability contributes to tumorigenesis in glioblastoma. Nature communications (February 2019) Cictm1a(KOMP)Wtsi PMC6368580
ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism. Neuron (March 2018) Cictm1c(KOMP)Wtsi 29526553
Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma. Proceedings of the National Academy of Sciences of the United States of America (January 2018) Cictm1c(KOMP)Wtsi PMC5816173
Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation. Cancer research (September 2017) Cictm2a(KOMP)Wtsi PMC5690824
Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5. Nature communications (July 2017) Cictm1c(KOMP)Wtsi Cictm1a(KOMP)Wtsi PMC5510180
Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans. Nature genetics (March 2017) Cictm1c(KOMP)Wtsi Cictm1a(KOMP)Wtsi Cictm1b(KOMP)Wtsi PMC5374026

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MGI Allele Allele Type Produced
Cictm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Cictm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Cictm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Cictm2e(KOMP)Wtsi Targeted, non-conditional allele ES Cells

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