Gene Summary

Name:
telomere maintenance 2
Synonyms:
1200003M09Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Telo2em1(IMPC)J HOM   Early adult 0.00
embryonic lethality prior to organogenesis Telo2em1(IMPC)J HOM   E9.5 0.00
increased total body fat amount Telo2em1(IMPC)J HET Early adult 5.44×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Lateral Orientation

9 Images

X-ray

XRay Images Whole Body Dorso Ventral

9 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

9 Images

X-ray

XRay Images Whole Body Lateral Orientation

9 Images

X-ray

XRay Images Forepaw

9 Images

Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

8 Images

Human diseases caused by Telo2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Telo2 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Telo2-Related Intellectual Disability-Neurodevelopmental Disorder
Knee flexion contracture, Hip contracture ORPHA:488642
You-Hoover-Fong Syndrome
OMIM:616954

The table below shows human diseases predicted to be associated to Telo2 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Telo2-Related Intellectual Disability-Neurodevelopmental Disorder
Knee flexion contracture, Hip contracture ORPHA:488642
You-Hoover-Fong Syndrome
OMIM:616954

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Telo2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Telo2.

No publications found that use IMPC mice or data for Telo2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Telo2em1(IMPC)J Exon Deletion Mice
Telo2tm2e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Telo2tm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Telo2tm43325(L1L2_gt2) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Telo2tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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