Gene: Ipo9 MGI:1918944
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The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
edema | Ipo9em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
abnormal embryo development | Ipo9em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
abnormal forebrain development | Ipo9em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
abnormal chorioallantoic fusion | Ipo9em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
abnormal embryo turning | Ipo9em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
abnormal vitelline vasculature morphology | Ipo9em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
preweaning lethality, complete penetrance | Ipo9em1(IMPC)Bay | HOM | Early adult | 0.00 | ||
abnormal heart morphology | Ipo9em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
abnormal pharyngeal arch morphology | Ipo9em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
abnormal tail bud morphology | Ipo9em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
embryonic lethality prior to tooth bud stage | Ipo9em1(IMPC)Bay | HOM | E12.5 | 0.00 | ||
abnormal allantois morphology | Ipo9em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
embryonic growth retardation | Ipo9em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
abnormal embryo size | Ipo9em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
abnormal neural tube closure | Ipo9em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
abnormal hindbrain development | Ipo9em1(IMPC)Bay | HOM | E9.5 | 0.00 | ||
abnormal midbrain development | Ipo9em1(IMPC)Bay | HOM | E9.5 | 0.00 |
Human diseases caused by Ipo9 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Ipo9 by phenotypic similarity.
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MGI Allele | Allele Type | Produced |
---|---|---|
Ipo9tm2e(EUCOMM)Wtsi | Targeted, non-conditional allele | ES Cells |
Ipo9tm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Ipo9em1(IMPC)Bay | Exon Deletion | Mice |
Ipo9tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Ipo9tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | ES Cells |
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