Gene Summary

Name:
importin 9
Synonyms:
0710008K06Rik,  Imp9

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal embryo turning Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal embryo size Ipo9em1(IMPC)Bay HOM E9.5 0.00
preweaning lethality, complete penetrance Ipo9em1(IMPC)Bay HOM   Early adult 0.00
abnormal vitelline vasculature morphology Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal neural tube closure Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal tail bud morphology Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal pharyngeal arch morphology Ipo9em1(IMPC)Bay HOM E9.5 0.00
edema Ipo9em1(IMPC)Bay HOM E9.5 0.00
embryonic growth retardation Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal heart morphology Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal allantois morphology Ipo9em1(IMPC)Bay HOM E9.5 0.00
embryonic lethality prior to tooth bud stage Ipo9em1(IMPC)Bay HOM   E12.5 0.00
abnormal midbrain development Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal hindbrain development Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal embryo development Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal chorioallantoic fusion Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal forebrain development Ipo9em1(IMPC)Bay HOM E9.5 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

Eye Morphology

VIP of left eye

17 Images

Eye Morphology

VIP of right eye

17 Images

Eye Morphology

VIP of left fundus

17 Images

X-ray

XRay Images Forepaw

10 Images

MicroCT E9.5

Embryo reconstruction

7 Images

Eye Morphology

VIP of right fundus

17 Images

X-ray

XRay Images Skull Lateral Orientation

10 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

Electrocardiogram (ECG)

Waveform Image

1 Images

Human diseases caused by Ipo9 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ipo9 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Neural tube defect OMIM:615041
Lambert Syndrome
Intrauterine growth retardation, Branchial anomaly, Ventricular septal defect ORPHA:1296
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Myelopathy, Htlv-1-Associated
Myelopathy OMIM:159580
Spina Bifida-Hypospadias Syndrome
Spinal dysraphism, Spina bifida ORPHA:3176
Verheij Syndrome
Truncus arteriosus, Short stature, Growth delay, Intrauterine growth retardation, Short neck, Ven... OMIM:615583
X-Linked Mandibulofacial Dysostosis
Webbed neck, Branchial anomaly, Short stature, Abnormal mitral valve morphology, Pulmonic stenosis ORPHA:1131
Branchiogenic-Deafness Syndrome
Short stature, Branchial fistula, Branchial cyst OMIM:609166
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome
Bicuspid aortic valve, Atrioventricular canal defect, Branchial anomaly, Pleural effusion, Increa... ORPHA:453499
Branchiootic Syndrome 3
Branchial cyst OMIM:608389
X-Linked Microcephaly-Growth Retardation-Prognathism-Cryptorchidism Syndrome
Severe postnatal growth retardation, Branchial cyst ORPHA:435938
Branchiootic Syndrome 1
Branchial fistula OMIM:602588
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Aminopterin/Methotrexate Embryofetopathy
Situs inversus totalis, Anencephaly, Encephalocele, Meningocele, Hydrocephalus, Short stature, Ho... ORPHA:1908
Branchiogenic Deafness Syndrome
Short stature, Branchial fistula, Branchial cyst ORPHA:50815
Holoprosencephaly
Encephalocele, Hydrocephalus, Branchial anomaly, Holoprosencephaly, Tetralogy of Fallot, Short ne... ORPHA:2162
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Isolated Posterior Meningocele
Neural tube defect, Hydromyelia, Meningocele, Hydrocephalus, Lipomyelomeningocele, Occipital meni... ORPHA:268810
Blepharocheilodontic Syndrome 1
Neural tube defect OMIM:119580
Distal 22Q11.2 Microduplication Syndrome
Tricuspid valve prolapse, Palpebral edema, Webbed neck, Hydrocephalus, Low posterior hairline, Pa... ORPHA:261337
Oligomeganephronia
Secundum atrial septal defect, Dehydration, Branchial cyst ORPHA:2260
Branchiootic Syndrome
Branchial fistula ORPHA:52429
Bor Syndrome
Branchial cyst ORPHA:107
Branchiootorenal Syndrome 1
Branchial fistula, Branchial cyst OMIM:113650
Distal 22Q11.2 Microdeletion Syndrome
Truncus arteriosus, Short stature, Growth delay, Intrauterine growth retardation, Atrial septal d... ORPHA:261330
Alg3-Cdg
Cardiomyopathy, Neural tube defect ORPHA:79321
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To A Point Mutation
Branchial anomaly, Increased nuchal translucency, Growth delay, Abnormal heart morphology, Cystic... ORPHA:453504
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To 9Q21.3 Microdeletion
Branchial anomaly, Increased nuchal translucency, Growth delay, Abnormal heart morphology, Cystic... ORPHA:352665
Craniorachischisis
Sirenomelia, Anencephaly, Myelomeningocele, Spinal dysraphism, Cervical spina bifida ORPHA:63260
8Q24.3 Microdeletion Syndrome
Atrioventricular canal defect, Spina bifida occulta, Truncus arteriosus, Branchial cyst, Dysplast... ORPHA:508488
Vertebral, Cardiac, Renal, And Limb Defects Syndrome 1
Short stature, Aortic valve stenosis, Mitral stenosis, Spinal dysraphism, Atrial septal defect, H... OMIM:617660
Aprosencephaly Syndrome
Aprosencephaly, Anencephaly OMIM:207770
Facial Dysmorphism-Developmental Delay-Behavioral Abnormalities Syndrome Due To Wac Point Mutation
Branchial anomaly ORPHA:466950
Treacher-Collins Syndrome
Branchial fistula, Encephalocele, Patent ductus arteriosus ORPHA:861
Branchial Arch Abnormalities, Choanal Atresia, Athelia, Hearing Loss, And Hypothyroidism Syndrome
Polyhydramnios, Patent foramen ovale, Short stature, Natal tooth, Right ventricular hypertrophy, ... OMIM:620186
Iniencephaly
Polyhydramnios, Rhizomelia, Anencephaly, Encephalocele, Hydrocephalus, Myelomeningocele, Spina bi... ORPHA:63259
Sacral Defect With Anterior Meningocele
Myeloschisis, Hydromyelia, Meningocele, Hydrocephalus, Dermal sinus tract, Myelomeningocele OMIM:600145
Craniofacial Microsomia 1
Occipital encephalocele, Hydrocephalus, Branchial anomaly, Tetralogy of Fallot, Patent ductus art... OMIM:164210
Branchiooculofacial Syndrome
Postnatal growth retardation, Branchial anomaly, Low posterior hairline, Intrauterine growth reta... OMIM:113620
Witteveen-Kolk Syndrome
Polyhydramnios, Short stature, Growth delay, Intrauterine growth retardation, Branchial fistula OMIM:613406
Alobar Holoprosencephaly
Neural tube defect, Hydrocephalus, Short stature, Growth delay, Abnormal heart morphology ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Neural tube defect, Hydrocephalus, Short stature, Growth delay, Abnormal heart morphology ORPHA:93926
Lobar Holoprosencephaly
Neural tube defect, Hydrocephalus, Short stature, Growth delay, Abnormal heart morphology ORPHA:93924
Semilobar Holoprosencephaly
Neural tube defect, Hydrocephalus, Short stature, Growth delay, Abnormal heart morphology ORPHA:220386
Schinzel-Giedion Syndrome
Neural tube defect, Delayed eruption of teeth, Abnormal heart morphology, Umbilical hernia, Short... ORPHA:798
Aprosencephaly And Cerebellar Dysgenesis
Aprosencephaly OMIM:601374

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ipo9

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ipo9.

No publications found that use IMPC mice or data for Ipo9.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Ipo9tm2e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Ipo9em1(IMPC)Bay Exon Deletion Mice
Ipo9tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ipo9tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ipo9tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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