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Gene: Ipo9 MGI:1918944

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Gene Summary

Name:
importin 9
Synonyms:
0710008K06Rik,  Imp9

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IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
edema Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal embryo development Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal forebrain development Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal chorioallantoic fusion Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal embryo turning Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal vitelline vasculature morphology Ipo9em1(IMPC)Bay HOM E9.5 0.00
preweaning lethality, complete penetrance Ipo9em1(IMPC)Bay HOM   Early adult 0.00
abnormal heart morphology Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal pharyngeal arch morphology Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal tail bud morphology Ipo9em1(IMPC)Bay HOM E9.5 0.00
embryonic lethality prior to tooth bud stage Ipo9em1(IMPC)Bay HOM   E12.5 0.00
abnormal allantois morphology Ipo9em1(IMPC)Bay HOM E9.5 0.00
embryonic growth retardation Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal embryo size Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal neural tube closure Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal hindbrain development Ipo9em1(IMPC)Bay HOM E9.5 0.00
abnormal midbrain development Ipo9em1(IMPC)Bay HOM E9.5 0.00

Download data as:  TSV  XLS

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Viewing: all phenotypes
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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Eye Morphology

VIP of right eye

17 Images

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X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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Eye Morphology

VIP of left eye

17 Images

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Eye Morphology

VIP of left fundus

17 Images

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X-ray

XRay Images Skull Lateral Orientation

10 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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MicroCT E9.5

Embryo reconstruction

7 Images

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Eye Morphology

VIP of right fundus

17 Images

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X-ray

XRay Images Forepaw

10 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

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Electrocardiogram (ECG)

Waveform Image

1 Images

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Human diseases caused by Ipo9 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ipo9 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Neural tube defect OMIM:615041
Lambert Syndrome
Ventricular septal defect, Branchial anomaly, Intrauterine growth retardation ORPHA:1296
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Spina Bifida-Hypospadias Syndrome
Spina bifida, Spinal dysraphism ORPHA:3176
X-Linked Mandibulofacial Dysostosis
Webbed neck, Branchial anomaly, Short stature, Abnormal mitral valve morphology, Pulmonic stenosis ORPHA:1131
Branchiogenic-Deafness Syndrome
Branchial cyst, Branchial fistula, Short stature OMIM:609166
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Branchiootic Syndrome 3
Branchial cyst OMIM:608389
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome
Atrioventricular canal defect, Branchial anomaly, Ventricular septal defect, Bicuspid aortic valv... ORPHA:453499
X-Linked Microcephaly-Growth Retardation-Prognathism-Cryptorchidism Syndrome
Branchial cyst, Severe postnatal growth retardation ORPHA:435938
Branchiootic Syndrome 1
Branchial fistula OMIM:602588
Aminopterin/Methotrexate Embryofetopathy
Meningocele, Spinal dysraphism, Encephalocele, Ventricular septal defect, Short stature, Anenceph... ORPHA:1908
Branchiogenic Deafness Syndrome
Branchial cyst, Branchial fistula, Short stature ORPHA:50815
Holoprosencephaly
Spinal dysraphism, Encephalocele, Branchial anomaly, Ventricular septal defect, Hydrocephalus, Ho... ORPHA:2162
Posterior Meningocele
Meningocele, Neural tube defect, Occipital meningocele, Hydromyelia, Hydrocephalus, Limitation of... ORPHA:268810
Blepharocheilodontic Syndrome 1
Neural tube defect OMIM:119580
Distal 22Q11.2 Microduplication Syndrome
Patent ductus arteriosus, Webbed neck, Ventricular septal defect, Hydrocephalus, Palpebral edema,... ORPHA:261337
Oligomeganephronia
Branchial cyst, Secundum atrial septal defect, Dehydration ORPHA:2260
Branchiootic Syndrome
Branchial fistula ORPHA:52429
Bor Syndrome
Branchial cyst ORPHA:107
Branchiootorenal Syndrome 1
Branchial cyst, Branchial fistula OMIM:113650
Distal 22Q11.2 Microdeletion Syndrome
Truncus arteriosus, Ventricular septal defect, Short stature, Atrial septal defect, Growth delay,... ORPHA:261330
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To A Point Mutation
Branchial anomaly, Ventricular septal defect, Bicuspid aortic valve, Atrial septal defect, Abnorm... ORPHA:453504
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To 9Q21.3 Microdeletion
Branchial anomaly, Ventricular septal defect, Bicuspid aortic valve, Atrial septal defect, Abnorm... ORPHA:352665
Alg3-Cdg
Cardiomyopathy, Neural tube defect ORPHA:79321
Craniorachischisis
Spinal dysraphism, Myelomeningocele, Anencephaly, Sirenomelia, Cervical spina bifida ORPHA:63260
Vertebral, Cardiac, Renal, And Limb Defects Syndrome 1
Spinal dysraphism, Short stature, Mitral stenosis, Atrial septal defect, Hypoplastic left heart, ... OMIM:617660
8Q24.3 Microdeletion Syndrome
Patent ductus arteriosus, Atrioventricular canal defect, Infancy onset short-trunk short stature,... ORPHA:508488
Facial Dysmorphism-Developmental Delay-Behavioral Abnormalities Syndrome Due To Wac Point Mutation
Branchial anomaly ORPHA:466950
Treacher-Collins Syndrome
Patent ductus arteriosus, Branchial fistula, Encephalocele ORPHA:861
Iniencephaly
Polyhydramnios, Spinal dysraphism, Encephalocele, Myelomeningocele, Rhizomelia, Spina bifida, Ane... ORPHA:63259
Sacral Defect With Anterior Meningocele
Meningocele, Myelomeningocele, Hydromyelia, Hydrocephalus, Myeloschisis, Dermal sinus tract OMIM:600145
Craniofacial Microsomia
Patent ductus arteriosus, Branchial anomaly, Ventricular septal defect, Hydrocephalus, Occipital ... OMIM:164210
Branchiooculofacial Syndrome
Branchial anomaly, Short neck, Low posterior hairline, Intrauterine growth retardation, Postnatal... OMIM:113620
Witteveen-Kolk Syndrome
Polyhydramnios, Short stature, Growth delay, Branchial fistula, Intrauterine growth retardation OMIM:613406
Alobar Holoprosencephaly
Short stature, Neural tube defect, Hydrocephalus, Growth delay, Abnormal heart morphology ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Short stature, Neural tube defect, Hydrocephalus, Growth delay, Abnormal heart morphology ORPHA:93926
Lobar Holoprosencephaly
Short stature, Neural tube defect, Hydrocephalus, Growth delay, Abnormal heart morphology ORPHA:93924
Semilobar Holoprosencephaly
Short stature, Neural tube defect, Hydrocephalus, Growth delay, Abnormal heart morphology ORPHA:220386
Schinzel-Giedion Syndrome
Delayed eruption of teeth, Neural tube defect, Short neck, Abnormal heart morphology, Umbilical h... ORPHA:798

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ipo9

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ipo9.

No publications found that use IMPC mice or data for Ipo9.

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MGI Allele Allele Type Produced
Ipo9tm2e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Ipo9tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ipo9em1(IMPC)Bay Exon Deletion Mice
Ipo9tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ipo9tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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