Gene Summary

Name:
YTH N6-methyladenosine RNA binding protein 3
Synonyms:
9130022A11Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal liver morphology Ythdf3em1(IMPC)Mbp HOM Early adult 0.00
increased circulating alanine transaminase level Ythdf3em1(IMPC)Mbp HOM Early adult 9.33×10-07
enlarged thymus Ythdf3em1(IMPC)Mbp HOM Early adult 0.00
abnormal thymus morphology Ythdf3em1(IMPC)Mbp HOM Early adult 0.00
small liver Ythdf3em1(IMPC)Mbp HOM Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

54 Images

X-ray

XRay Images Whole Body Lateral Orientation

18 Images

Human diseases caused by Ythdf3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ythdf3 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Isolated Anencephaly
Thymus hyperplasia ORPHA:563609
Proteus-Like Syndrome
Thymus hyperplasia, Abnormality of the parathyroid gland, Splenomegaly, Polycystic ovaries ORPHA:2969
Myopathy, Epilepsy, And Progressive Cerebral Atrophy
Thymus hyperplasia OMIM:619036
Proteus Syndrome
Ovarian neoplasm, Macroorchidism, Splenomegaly, Testicular neoplasm, Thymus hyperplasia, Enlarged... ORPHA:744

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ythdf3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ythdf3.

No publications found that use IMPC mice or data for Ythdf3.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Ythdf3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ythdf3tm3a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ythdf3em1(IMPC)Mbp Exon Deletion Mice, Tissue
Ythdf3tm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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