Llgl2 | LLGL2 scribble cell polarity complex component

GeneMGI:1918843Synonyms: 9130006H11Rik

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Behavior/neurological Mortality/aging

17 No significant impact

4 Not tested

Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues

Phenotypes

preweaning lethality, complete penetrance1 supporting datasetLlgl2tm1b(KOMP)WtsihomozygoteEarly adultN/A * 
decreased circulating HDL cholesterol level1 supporting datasetLlgl2tm1b(KOMP)WtsiheterozygoteEarly adult4.94x10-5 
increased startle reflex1 supporting datasetLlgl2tm1b(KOMP)WtsiheterozygoteEarly adult1.17x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoteSection images
100% (2/2)0.7% (4/570)
aortaheterozygoteSection images
100% (1/1)0.19% (1/533)
brainheterozygoten/a0% (0/2)0.86% (5/579)
brainstemheterozygoten/a0% (0/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/a0% (0/2)0.22% (1/454)
cerebellumheterozygoten/a0% (0/2)0.56% (3/532)
cerebral cortexheterozygoten/a0% (0/2)0.41% (2/491)
epididymisheterozygoteSection images
100% (1/1)87.5% (21/24)
esophagusheterozygoteSection images
100% (2/2)1.67% (7/419)
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Histopathology

IMPC related publications

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Llgl2tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Llgl2tm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Llgl2tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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