Piezo2 | piezo-type mechanosensitive ion channel component 2

GeneMGI:1918781Synonyms: Fam38b, 9430028L06Rik, +3 more

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Embryo Growth/size/body region Behavior/neurological Mortality/aging

14 No significant impact

5 Not tested

Gene metrics:4Significant phenotypes
7Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

preweaning lethality, complete penetrance1 supporting datasetPiezo2em1(IMPC)JhomozygoteEarly adultN/A * 
increased vertical activity1 supporting datasetPiezo2em2(IMPC)JheterozygoteEarly adult7.33x10-6 
preweaning lethality, complete penetrance1 supporting datasetPiezo2em2(IMPC)JhomozygoteEarly adultN/A * 
abnormal embryo size1 supporting datasetPiezo2em2(IMPC)JhomozygoteE18.5N/A * 
increased circulating triglyceride level1 supporting datasetPiezo2em2(IMPC)JheterozygoteEarly adult7.9x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Piezo2em1(IMPC)JExon Deletionmouse
Piezo2em2(IMPC)JExon Deletionmouse
Piezo2tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Piezo2tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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