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Genes Phenotypes Help, News, Blog

Gene: Kazn MGI:1918779

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Gene Summary

Name:
kazrin, periplakin interacting protein
Synonyms:
2310007B04Rik,  9030409G11Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased total body fat amount Kazntm1a(EUCOMM)Wtsi HOM   Early adult 7.54×10-07
decreased body weight Kazntm1a(EUCOMM)Wtsi HOM Early adult 2.18×10-07
decreased bone mineral content Kazntm1a(EUCOMM)Wtsi HOM Early adult 5.85×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Legacy Phenotype Associated Images
Kazntm1a(EUCOMM)Wtsi
forearm, WT, Male, WTSI
Kazntm1a(EUCOMM)Wtsi
body, WT, Male, WTSI
Kazntm1a(EUCOMM)Wtsi
body, WT, Male, WTSI
Kazntm1a(EUCOMM)Wtsi
body, WT, Female, WTSI
Kazntm1a(EUCOMM)Wtsi
head, WT, Female, WTSI

View all 170 images

Kazntm1a(EUCOMM)Wtsi
anterior commissure, decreased anterior commissure size, HOM, Male, WTSI
Kazntm1a(EUCOMM)Wtsi
WT, Male, WTSI
Kazntm1a(EUCOMM)Wtsi
lateral ventricle, enlarged lateral ventricles, HOM, Male, WTSI
Kazntm1a(EUCOMM)Wtsi
enlarged third ventricle, 3rd ventricle, HOM, Male, WTSI
Kazntm1a(EUCOMM)Wtsi
anterior commissure, decreased anterior commissure size, HOM, Male, WTSI

View all 11 images

Kazntm1a(EUCOMM)Wtsi
eye, corneal opacity, iris synechia, fused cornea and lens, HOM, Female, WTSI
Kazntm1a(EUCOMM)Wtsi
eye, eyelids fail to open, HOM, Female, WTSI
Kazntm1a(EUCOMM)Wtsi
back skin, HOM, Female, WTSI
Kazntm1a(EUCOMM)Wtsi
back skin, HOM, Female, WTSI

Human diseases caused by Kazn mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Kazn

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Kazn.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Kazntm1a(EUCOMM)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Kazntm1a(EUCOMM)Wtsi PMC6459510
Exons 5-15 of kazrin are dispensable for murine epidermal morphogenesis and homeostasis. The Journal of investigative dermatology (April 2012) Kazntm1c(EUCOMM)Wtsi Kazntm1a(EUCOMM)Wtsi Kazntm1d(EUCOMM)Wtsi PMC3398255

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Kazntm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Kazntm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Kazntm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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