Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
fibronectin leucine rich transmembrane protein 3
Synonyms:
5530600M07Rik,  C430047I10Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Flrt3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Flrt3 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Hypogonadotropic Hypogonadism 21 With Or Without Anosmia
Delayed puberty OMIM:615271
Kallmann Syndrome
Delayed puberty ORPHA:478

The table below shows human diseases predicted to be associated to Flrt3 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Spina Bifida-Hypospadias Syndrome
Spinal dysraphism, Spina bifida ORPHA:3176
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Hypoplastic left heart, Anencephaly, Ventricular septal defect, Spina bifida, Gastroschisis ORPHA:2476
Neural Tube Defects, X-Linked
Spina bifida, Anencephaly OMIM:301410
Anencephaly 1
Spina bifida, Anencephaly OMIM:206500
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Craniorachischisis
Myelomeningocele, Cervical spina bifida, Anencephaly, Sirenomelia, Spinal dysraphism, Omphalocele ORPHA:63260
Blepharocheilodontic Syndrome 1
Neural tube defect OMIM:119580
Alg3-Cdg
Cardiomyopathy, Neural tube defect ORPHA:79321
Posterior Meningocele
Occipital meningocele, Hydrocephalus, Neural tube defect, Meningocele, Lipomyelomeningocele ORPHA:268810
Semilobar Holoprosencephaly
Hydrocephalus, Neural tube defect, Abnormal heart morphology ORPHA:220386
Alobar Holoprosencephaly
Hydrocephalus, Neural tube defect, Abnormal heart morphology ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Hydrocephalus, Neural tube defect, Abnormal heart morphology ORPHA:93926
Lobar Holoprosencephaly
Hydrocephalus, Neural tube defect, Abnormal heart morphology ORPHA:93924
Schinzel-Giedion Syndrome
Abnormal heart morphology, Inguinal hernia, Neural tube defect, Umbilical hernia ORPHA:798
Hypogonadotropic Hypogonadism 21 With Or Without Anosmia
Delayed puberty OMIM:615271
Kallmann Syndrome
Delayed puberty ORPHA:478

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Flrt3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Flrt3.

No publications found that use IMPC mice or data for Flrt3.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Flrt3tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Flrt3tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Flrt3tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Flrt3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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