Pex1 | peroxisomal biogenesis factor 1
Physiological systems
18 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Muscle Liver/biliary system Cardiovascular system Mortality/aging
14 No significant impact
6 Not tested
Data collections
Gene metrics:5Significant phenotypes
7Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
decreased cardiac muscle contractility | 2 supporting datasets | Pex1tm1e.1(EUCOMM)Hmgu | heterozygote | Early adult | 1.03x10-6 | ||
decreased heart rate | 1 supporting dataset | Pex1tm1e.1(EUCOMM)Hmgu | heterozygote | Early adult | 2.31x10-8 | ||
preweaning lethality, complete penetrance | 1 supporting dataset | Pex1tm1e.1(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
dilated heart left ventricle | 2 supporting datasets | Pex1tm1e.1(EUCOMM)Hmgu | heterozygote | Early adult | 2.2x10-7 | ||
abnormal liver morphology | 1 supporting dataset | Pex1tm1e.1(EUCOMM)Hmgu | heterozygote | Early adult | N/A * |
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External links
No external links available for Pex1.
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Pex1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
Pex1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell mouse |
Pex1tm1e.1(EUCOMM)Hmgu | Promoter excision from Targeted, non-conditional allele | | mouse |
Pex1tm46430(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |