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Gene: Jmjd1c MGI:1918614

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Gene Summary

Name:
jumonji domain containing 1C
Synonyms:
TRIP8,  D630035I23Rik,  5430433L24Rik

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, incomplete penetrance Jmjd1ctm1a(EUCOMM)Wtsi HOM   Early adult 0.00
mydriasis Jmjd1ctm1a(EUCOMM)Wtsi HET Early adult 2.43×10-07
vertebral transformation Jmjd1ctm1a(EUCOMM)Wtsi HET Early adult 2.53×10-08
abnormal iris morphology Jmjd1ctm1a(EUCOMM)Wtsi HET Early adult 8.99×10-05

Download data as:  TSV  XLS

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Lateral Orientation

14 Images

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X-ray

XRay Images Forepaw

12 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

16 Images

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X-ray

XRay Images Whole Body Lateral Orientation

14 Images

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X-ray

XRay Images Whole Body Dorso Ventral

14 Images

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Legacy Phenotype Associated Images
Jmjd1ctm1a(EUCOMM)Wtsi
HET, Female, WTSI
Jmjd1ctm1a(EUCOMM)Wtsi
HET, Male, WTSI
Jmjd1ctm1a(EUCOMM)Wtsi
HET, Male, WTSI
Jmjd1ctm1a(EUCOMM)Wtsi
HET, Male, WTSI
Jmjd1ctm1a(EUCOMM)Wtsi
HET, Male, WTSI

View all 70 images

Jmjd1ctm1a(EUCOMM)Wtsi
mydriasis, abnormal pupil morphology, HET, Female, WTSI
Jmjd1ctm1a(EUCOMM)Wtsi
mydriasis, abnormal pupil morphology, HET, Female, WTSI
Jmjd1ctm1a(EUCOMM)Wtsi
abnormal pupil morphology, mydriasis, HET, Male, WTSI

Human diseases caused by Jmjd1c mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Jmjd1c by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
22Q11.2 Deletion Syndrome
Cataract, Corneal neovascularization, Short neck, Posterior embryotoxon, Scoliosis ORPHA:567

The table below shows human diseases predicted to be associated to Jmjd1c by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Iris Pigment Epithelium Anomalies
Iris cyst OMIM:601616
Pupillary Membrane, Persistence Of
Persistent pupillary membrane, Developmental cataract, Megalocornea OMIM:178900
Exfoliation Syndrome
Cataract, Mydriasis, Pseudoexfoliation, Abnormal lens morphology, Phakodonesis, Pigment depositio... OMIM:177650
X-Linked Corneal Dermoid
Abnormal pupil morphology, Corneal opacity ORPHA:1661
Anterior Segment Dysgenesis 8
Cataract, Ectopia lentis, Ectopia pupillae, Hypoplasia of the iris, Uveal ectropion, Corneal stro... OMIM:617319
Klippel-Feil Syndrome 3, Autosomal Dominant
Chorioretinal coloboma, Cervical C3/C4 vertebral fusion, Cervical C5/C6 vertebrae fusion, Thoraci... OMIM:613702
Cataract 50 With Or Without Glaucoma
Cataract, Persistent pupillary membrane OMIM:620253
Anterior Segment Dysgenesis 3
Peters anomaly, Ectopia pupillae, Rieger anomaly, Abnormal iris vasculature, Axenfeld anomaly, Po... OMIM:601631
Microphthalmia/Coloboma 10
Iris coloboma, Microcoria, Chorioretinal coloboma OMIM:616428
Uveal Melanoma
Inferior lens subluxation, Mydriasis, Iris melanoma, Ciliary body melanoma, Zonular cataract ORPHA:39044
Galactosialidosis
Abnormal vertebral morphology, Abnormality of the vertebral column, Corneal opacity ORPHA:351
Corneal Dystrophy, Posterior Amorphous
Iris coloboma, Corneal dystrophy, Ectopia pupillae OMIM:612868
Ectopia Pupillae
Ectopia pupillae OMIM:129750
Ectopia Lentis Et Pupillae
Cataract, Ectopia lentis, Ectopia pupillae, Iris transillumination defect, Persistent pupillary m... OMIM:225200
Microcoria, Congenital
Miosis, Hypoplasia of the iris dilator muscle, Microcoria OMIM:156600
Corneal Dystrophy, Posterior Polymorphous, 4
Ectopia pupillae OMIM:618031
Facial Spasm
Anisocoria OMIM:134300
Microphthalmia/Coloboma 7
Inferior chorioretinal coloboma, Iris coloboma OMIM:614497
Cataract-Microcornea Syndrome
Cataract, Microcornea, Corneal opacity, Iris coloboma, Corneal dystrophy ORPHA:1377
X-Linked Intellectual Disability-Retinitis Pigmentosa Syndrome
Iris hypopigmentation ORPHA:85332
Microphthalmia/Coloboma 3
Cataract, Iris coloboma OMIM:610092
Megalocornea
Cataract, Deep anterior chamber, Megalocornea, Lens subluxation, Astigmatism, Iridodonesis, Iris ... OMIM:309300
Iridocorneal Endothelial Syndrome
Posterior synechiae of the anterior chamber, Central heterochromia, Ectopia pupillae, Abnormal mi... ORPHA:64734
Aniridia-Ptosis-Intellectual Disability-Familial Obesity Syndrome
Cataract, Persistent pupillary membrane, Aplasia/Hypoplasia of the iris, Corneal opacity ORPHA:1067
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 4
Mydriasis OMIM:619365
Deafness, Autosomal Recessive 108
Iris coloboma OMIM:617654
Intestinal Botulism
Mydriasis ORPHA:178481
Toxin-Mediated Infectious Botulism
Mydriasis ORPHA:230800
Spondylocostal Dysostosis 6, Autosomal Recessive
Cervical kyphosis, Spinal canal stenosis, Butterfly vertebrae, Hemivertebrae, Scoliosis OMIM:616566
Corneal Dystrophy, Posterior Polymorphous, 3
Corneal guttata, Keratoconus, Corneal dystrophy, Ectopia pupillae OMIM:609141
Autosomal Recessive Ataxia Due To Pex10 Deficiency
Mydriasis ORPHA:247815
Intellectual Developmental Disorder With Ocular Anomalies And Distinctive Facial Features
Iris cyst OMIM:620086
Corneal Dystrophy, Posterior Polymorphous, 1
Band keratopathy, Abnormal corneal endothelium morphology, Ectopia pupillae, Thinning of Descemet... OMIM:122000
Charcot-Marie-Tooth Disease Type 1B
Abnormal pupil morphology, Scoliosis ORPHA:101082
Loose Anagen Syndrome
Iris coloboma ORPHA:168
Iatrogenic Botulism
Mydriasis ORPHA:254509
Wound Botulism
Mydriasis ORPHA:178475
Microphthalmia, Isolated, With Corectopia
Ectopia pupillae OMIM:156900
Inhalational Botulism
Mydriasis ORPHA:254504
Bilateral Acute Depigmentation Of The Iris
Abnormal corneal endothelium morphology, Pigment deposition in the trabecular meshwork, Abnormal ... ORPHA:69736
Aniridia, Microcornea, And Spontaneously Reabsorbed Cataract
Cataract, Aniridia, Microcornea OMIM:106230
Botulism
Mydriasis ORPHA:1267
Foodborne Botulism
Mydriasis ORPHA:228371
Cataract 21, Multiple Types
Iris coloboma, Microcornea, Peters anomaly, Cerulean cataract, Corneal opacity, Cortical pulverul... OMIM:610202
Aniridia 2
Lens subluxation, Cataract, Aniridia, Iris coloboma OMIM:617141
Ophthalmoplegia, Familial Static
Anisocoria OMIM:165000
Infant Botulism
Mydriasis, Keratoconjunctivitis sicca ORPHA:178478
Miller Fisher Syndrome
Mydriasis, Anisocoria ORPHA:98919
Coats Disease
Leukocoria OMIM:300216
Posterior Polymorphous Corneal Dystrophy
Increased corneal curvature, Ectopia pupillae, Uveal ectropion, Astigmatism, Abnormal Descemet me... ORPHA:98973
2Q24 Microdeletion Syndrome
Cataract, Short neck, Abnormality iris morphology ORPHA:1617
Amoebic Keratitis
Cataract, Corneal perforation, Abnormal cornea morphology, Punctate opacification of the cornea, ... ORPHA:67043
Neovascular Glaucoma
Rubeosis iridis, Uveal ectropion, Conjunctival hyperemia, Corneal stromal edema, Abnormal anterio... ORPHA:94058
X-Linked Recessive Ocular Albinism
Iris hypopigmentation, Abnormal pupil morphology, Astigmatism, Ocular albinism ORPHA:54
Serotonin Syndrome
Mydriasis ORPHA:43116
Woolly Hair
Cataract, Abnormal pupil morphology ORPHA:170
Anterior Segment Dysgenesis 6
Posterior synechiae of the anterior chamber, Abnormal Descemet membrane morphology, Corneal neova... OMIM:617315
Anterior Segment Dysgenesis 7
Cataract, Microcornea, Anterior synechiae of the anterior chamber, Ocular anterior segment dysgen... OMIM:269400
Arachnoid Cyst
Mydriasis, Back pain, Sciatica ORPHA:2356
Woolly Hair Nevus
Heterochromia iridis, Persistent pupillary membrane ORPHA:79414
Microspherophakia And/Or Megalocornea, With Ectopia Lentis And With Or Without Secondary Glaucoma
Microspherophakia, Ectopia lentis, Megalocornea, Iridodonesis, Buphthalmos, Deep anterior chamber OMIM:251750
Peters Anomaly
Peters anomaly, Thinning of Descemet membrane, Subcapsular cataract, Anterior synechiae of the an... ORPHA:708
Isolated Ectopia Lentis
Cataract, Ectopia lentis, Ectopia pupillae ORPHA:1885
Retinal Dystrophy And Iris Coloboma With Or Without Cataract
Iris coloboma, Posterior synechiae of the anterior chamber, Developmental cataract OMIM:616722
Weill-Marchesani Syndrome 4
Ectopia lentis, Posterior synechiae of the anterior chamber, Phakodonesis, Iridodonesis, Shallow ... OMIM:613195
Myopathy, Tubular Aggregate, 1
Abnormal pupil morphology OMIM:160565
Persistent Hyperplastic Primary Vitreous, Autosomal Recessive
Cataract, Microcornea, Posterior synechiae of the anterior chamber, Persistent pupillary membrane... OMIM:221900
Smooth Muscle Dysfunction Syndrome
Mydriasis OMIM:613834
Aniridia-Intellectual Disability Syndrome
Cataract, Aniridia, Ectopia lentis ORPHA:1068
Pituitary Apoplexy
Mydriasis ORPHA:95613
Trisomy 9P
Abnormal pupil morphology, Short neck, Scoliosis, Kyphosis, Sacral dimple ORPHA:236
Osteopetrosis, Autosomal Recessive 5
Mydriasis OMIM:259720
Hirschsprung Disease-Ganglioneuroblastoma Syndrome
Abnormal pupil morphology ORPHA:2151
Craniotubular Dysplasia, Ikegawa Type
Platyspondyly, Mydriasis, Increased intervertebral space OMIM:619727
Intellectual Developmental Disorder, X-Linked, Syndromic 17
Anisocoria OMIM:300858
Microcornea-Posterior Megalolenticonus-Persistent Fetal Vasculature-Coloboma Syndrome
Posterior lenticonus, Microcornea, Iris coloboma, Chorioretinal coloboma ORPHA:231736
Norrie Disease
Cataract, Hypoplasia of the iris, Opacification of the corneal stroma, Leukocoria, Corneal opacit... OMIM:310600
Alternating Hemiplegia Of Childhood
Mydriasis ORPHA:2131
Fuchs Heterochromic Iridocyclitis
Cataract, Chorioretinal scar, Corneal keratic precipitates, Iris atrophy, Heterochromia iridis, A... ORPHA:263479
Hec Syndrome
Abnormal pupil morphology, Developmental cataract ORPHA:2119
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 2
Mydriasis OMIM:619351
Bickerstaff Brainstem Encephalitis
Mydriasis, Anisocoria ORPHA:79138
Alexander Disease
Microcoria OMIM:203450
Edict Syndrome
Keratoconus, Microcornea, Hypoplasia of the iris, Astigmatism, Anterior polar cataract OMIM:614303
Anterior Segment Dysgenesis 2
Cataract, Microcornea, Peters anomaly, Posterior synechiae of the anterior chamber, Aniridia, Ant... OMIM:610256
Phacoanaphylactic Uveitis
Posterior uveitis, Anterior chamber flare grade 1+, Panuveitis, Hypopyon, Posterior synechiae of ... ORPHA:209959
Aniridia 1
Chorioretinal hypopigmentation, Cataract, Ectopia lentis, Hypoplasia of the iris, Ectopia pupilla... OMIM:106210
Axenfeld-Rieger Syndrome, Type 3
Ectopia pupillae, Posterior embryotoxon, Posterior synechiae of the anterior chamber, Hypoplasia ... OMIM:602482
Unilateral Ocular Duplication
Microcornea, Abnormal pupil morphology, Iris coloboma ORPHA:3374
Cocaine Intoxication
Mydriasis ORPHA:90068
Alagille Syndrome
Keratoconus, Abnormal form of the vertebral bodies, Abnormal pupil morphology, Vertebral segmenta... ORPHA:52
Distal Deletion 6P
Ectopia pupillae, Hypoplasia of the iris, Vertebral segmentation defect, Anterior synechiae of th... ORPHA:96125
Short Syndrome
Hypoplasia of the iris, Megalocornea, Abnormal pupil morphology, Posterior embryotoxon, Abnormal ... ORPHA:3163
Scorpion Envenomation
Miosis, Mydriasis ORPHA:466677
Oculopalatocerebral Syndrome
Leukocoria OMIM:257910
Chromosome 16Q12 Duplication Syndrome
Cataract, Anisocoria OMIM:619649
Axenfeld-Rieger Syndrome, Type 1
Microcornea, Abnormally prominent line of Schwalbe, Ectopia pupillae, Megalocornea, Hypoplasia of... OMIM:180500
Aortic Aneurysm, Familial Thoracic 6
Iris flocculi OMIM:611788
Oculoauricular Syndrome
Cataract, Microcornea, Posterior synechiae of the anterior chamber, Chorioretinal coloboma, Iris ... OMIM:612109
Persistent Hyperplastic Primary Vitreous
Cataract, Microcornea, Persistent pupillary membrane, Leukocoria, Developmental cataract, Corneal... ORPHA:91495
Retinitis Pigmentosa 97
Iris atrophy OMIM:620422
Duane Retraction Syndrome
Microcornea, Abnormal form of the vertebral bodies, Chorioretinal coloboma, Central heterochromia... ORPHA:233
Familial Dysautonomia
Abnormal pupil morphology, Heterochromia iridis, Corneal opacity, Scoliosis, Corneal erosion ORPHA:1764
Cutis Marmorata Telangiectatica Congenita
Leukocoria OMIM:219250
Intellectual Disability-Alacrima-Achalasia Syndrome
Anisocoria ORPHA:289483
Proteus-Like Syndrome
Heterochromia iridis, Cataract, Abnormal pupil morphology, Limbal dermoid ORPHA:2969
Spondylometaphyseal Dysplasia-Cone-Rod Dystrophy Syndrome
Platyspondyly, Ectopia pupillae, Corneal opacity, Lens subluxation, Scoliosis, Ovoid vertebral bo... ORPHA:85167
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 2
Cataract, Peters anomaly, Buphthalmos, Persistent pupillary membrane, Scoliosis, Spinal rigidity OMIM:613150
Megalocornea-Intellectual Disability Syndrome
Hypoplasia of the iris, Megalocornea, Astigmatism, Iridodonesis, Abnormal anterior chamber morpho... ORPHA:2479
Spondylometaphyseal Dysplasia With Cone-Rod Dystrophy
Platyspondyly, Ectopia pupillae, Severe platyspondyly, Corneal opacity, Lens subluxation, Scolios... OMIM:608940
Congenital Muscular Dystrophy With Cerebellar Involvement
Cataract, Lumbar hyperlordosis, Abnormality iris morphology, Megalocornea ORPHA:370959
Charcot-Marie-Tooth Disease Type 1E
Abnormal pupil morphology, Slow pupillary light response, Tonic pupil, Anisocoria ORPHA:90658
Plague
Conjunctival hyperemia, Mydriasis ORPHA:707
Late-Onset Retinal Degeneration
Choroidal neovascularization, Abnormal anterior eye segment morphology, Chorioretinal atrophy, Ab... ORPHA:67042
Congenital Fibrosis Of Extraocular Muscles
Cataract, Abnormal pupil shape, Slow pupillary light response, Miosis, Anisocoria ORPHA:45358
Osteoporosis-Pseudoglioma Syndrome
Platyspondyly, Cataract, Biconcave vertebral bodies, Kyphoscoliosis, Iris atrophy, Severe platysp... OMIM:259770
Juvenile Glaucoma
Abnormality iris morphology, Abnormal anterior chamber morphology ORPHA:98977
Microphthalmia/Coloboma And Skeletal Dysplasia Syndrome
Sclerocornea, Cataract, Microcornea, Ectopia pupillae OMIM:615877
Vertebral Anomalies And Variable Endocrine And T-Cell Dysfunction
Ectopia pupillae, Short neck, Hemivertebrae, Scoliosis, Kyphosis OMIM:618223
Ectodermal Dysplasia With Facial Dysmorphism And Acral, Ocular, And Brain Anomalies
Cataract, Astigmatism, Ectopia pupillae OMIM:618727
Nephronophthisis 11
Anisocoria OMIM:613550
Knobloch Syndrome 1
Band keratopathy, Chorioretinal atrophy, Iris transillumination defect, Cortical cataract, Develo... OMIM:267750
1Q41Q42 Microdeletion Syndrome
Abnormality iris morphology ORPHA:250999
Oculodentodigital Dysplasia, Autosomal Recessive
Cataract, Microcornea, Persistent pupillary membrane OMIM:257850
Charcot-Marie-Tooth Disease Type 4C
Abnormal pupillary light reflex, Anisocoria, Scoliosis, Neuropathic spinal arthropathy ORPHA:99949
Traboulsi Syndrome
Cataract, Ectopia lentis, Phakodonesis, Iris atrophy, Spherophakia, Anterior synechiae of the ant... OMIM:601552
Neuhauser Syndrome
Hypoplasia of the iris, Megalocornea, Iridodonesis, Iris transillumination defect, Corneal arcus OMIM:249310
Pierson Syndrome
Cataract, Hypoplasia of the iris, Rieger anomaly, Uveal ectropion, Hypoplasia of the ciliary body... OMIM:609049
Achalasia-Addisonianism-Alacrima Syndrome
Anisocoria OMIM:231550
Oculo-Palato-Cerebral Syndrome
Cataract, Leukocoria ORPHA:2714
Collagenoma, Familial Cutaneous
Iris atrophy OMIM:115250
Weill-Marchesani Syndrome 2
Cataract, Microspherophakia, Ectopia lentis, Spinal canal stenosis, Lumbar hyperlordosis, Astigma... OMIM:608328
Trichinellosis
Conjunctival hyperemia, Conjunctivitis, Abnormal uvea morphology, Anisocoria ORPHA:863
Norrie Disease
Cataract, Ectopia lentis, Hypoplasia of the iris, Abnormal pupil morphology, Aplasia/Hypoplasia o... ORPHA:649
Oculocerebrorenal Syndrome Of Lowe
Platyspondyly, Cataract, Lentiglobus, Abnormal pupil morphology, Chorioretinal dysplasia, Corneal... ORPHA:534
Cutis Marmorata Telangiectatica Congenita
Leukocoria, Scoliosis ORPHA:1556
Oculodentodigital Dysplasia
Cataract, Microcornea, Abnormality iris morphology, Abnormal form of the vertebral bodies ORPHA:2710
Revesz Syndrome
Leukocoria, Megalocornea OMIM:268130
Alacrima, Achalasia, And Impaired Intellectual Development Syndrome
Anisocoria OMIM:615510
Intellectual Developmental Disorder With Impaired Language And Dysmorphic Facies
Anisocoria, Scoliosis OMIM:618653
Superficial Siderosis
Anisocoria, Back pain ORPHA:247245
Retinoblastoma
Heterochromia iridis, Leukocoria, Hypopyon, Uveitis ORPHA:790
Retinoblastoma
Leukocoria OMIM:180200
Brain Small Vessel Disease 1 With Or Without Ocular Anomalies
Microcornea, Hypoplasia of the iris, Ectopia pupillae, Astigmatism, Corneal neovascularization, P... OMIM:175780
Scalp-Ear-Nipple Syndrome
Cataract, Anisocoria, Iris coloboma, Developmental cataract OMIM:181270
Wolf-Hirschhorn Syndrome
Iris coloboma, Abnormal form of the vertebral bodies, Ectopia pupillae, Rieger anomaly, Vertebral... OMIM:194190
Sponastrime Dysplasia
Platyspondyly, Cataract, Abnormality of the vertebral column, Lumbar hyperlordosis, Biconcave ver... ORPHA:93357
Familial Thoracic Aortic Aneurysm And Aortic Dissection
Scoliosis, Abnormality iris morphology ORPHA:91387
Multiple System Atrophy 1, Susceptibility To
Iris atrophy OMIM:146500
Tubulointerstitial Nephritis And Uveitis Syndrome
Posterior uveitis, Cataract, Choroidal neovascularization, Chorioretinal scar, Posterior synechia... ORPHA:91500
Neonatal Marfan Syndrome
Iridodonesis, Ectopia lentis, Megalocornea ORPHA:284979
Acrofrontofacionasal Dysostosis 1
Iris atrophy OMIM:201180
Witteveen-Kolk Syndrome
Cataract, Iris coloboma, Anisocoria, Scoliosis OMIM:613406
Mowat-Wilson Syndrome
Cataract, Microcornea, Chorioretinal coloboma, Ectopia pupillae, Iris coloboma OMIM:235730
Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation
Cataract, Microcornea, Ectopia pupillae, Abnormal pupil morphology, Axenfeld anomaly, Astigmatism... ORPHA:261552
Neurooculorenal Syndrome
Iris atrophy OMIM:620305
Vascular Ehlers-Danlos Syndrome
Keratoconus, Abnormal pupil morphology ORPHA:286
22Q11.2 Deletion Syndrome
Cataract, Corneal neovascularization, Short neck, Posterior embryotoxon, Scoliosis ORPHA:567

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Jmjd1c

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Jmjd1c.

There are 8 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Jmjd1ctm1a(EUCOMM)Wtsi PMC7263671
Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis. Nature communications (February 2020) Jmjd1ctm1a(EUCOMM)Wtsi PMC7005700
Jmjd1c is dispensable for healthy adult hematopoiesis and Jak2V617F-driven myeloproliferative disease initiation in mice. PloS one (February 2020) Jmjd1ctm1a(EUCOMM)Wtsi PMC6999878
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Jmjd1ctm1a(EUCOMM)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Jmjd1ctm1a(EUCOMM)Wtsi PMC6459510
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Jmjd1ctm1a(EUCOMM)Wtsi PMC5827107
MLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C. The Journal of clinical investigation (February 2016) Jmjd1ctm1c(EUCOMM)Wtsi Jmjd1ctm1a(EUCOMM)Wtsi PMC4767347
JMJD1C is required for the survival of acute myeloid leukemia by functioning as a coactivator for key transcription factors. Genes & development (October 2015) Jmjd1ctm1c(EUCOMM)Wtsi PMC4617977

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MGI Allele Allele Type Produced
Jmjd1ctm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Jmjd1ctm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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