Slc29a3 | solute carrier family 29 (nucleoside transporters), member 3

GeneMGI:1918529Synonyms: 4933435C21Rik, Ent3

Physiological systems

22 / 24 physiological systems tested

17 Significantly impacted by the knock-out

 Reproductive system Immune system Endocrine/exocrine gland Integument Adipose tissue Growth/size/body region Digestive/alimentary Hematopoietic system Cardiovascular system Renal/urinary system Homeostasis/metabolism Limbs/digits/tail Nervous system Liver/biliary system Respiratory system Behavior/neurological Skeleton

5 No significant impact

2 Not tested

Gene metrics:58Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

enlarged lymph nodes2 supporting datasetsSlc29a3em1(IMPC)MbphomozygoteEarly adultN/A * 
abnormal uterus morphology1 supporting datasetSlc29a3em1(IMPC)MbphomozygoteEarly adultN/A * 
abnormal kidney morphology2 supporting datasetsSlc29a3em1(IMPC)MbphomozygoteEarly adultN/A * 
decreased hematocrit1 supporting datasetSlc29a3em1(IMPC)WtsihomozygoteEarly adult4.58x10-48 
enlarged spleen2 supporting datasetsSlc29a3em1(IMPC)MbphomozygoteEarly adultN/A * 
decreased circulating serum albumin level1 supporting datasetSlc29a3em1(IMPC)WtsihomozygoteEarly adult5.75x10-16 
abnormal spleen morphology2 supporting datasetsSlc29a3em1(IMPC)MbphomozygoteEarly adultN/A * 
abnormal lymph node morphology2 supporting datasetsSlc29a3em1(IMPC)MbphomozygoteEarly adultN/A * 
increased circulating bilirubin level1 supporting datasetSlc29a3em1(IMPC)WtsihomozygoteEarly adult1.25x10-29 
small seminal vesicle1 supporting datasetSlc29a3em1(IMPC)MbphomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Slc29a3em1(IMPC)MbpExon Deletionmouse
Slc29a3em1(IMPC)WtsiPoint Mutationmouse
Slc29a3tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell
Slc29a3tm48176(L1L2_Pgk_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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