Spata24 | spermatogenesis associated 24

GeneMGI:1918492Synonyms: TIPT, 2700012K08Rik, +3 more

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Immune system Vision/eye Hematopoietic system Behavior/neurological

15 No significant impact

5 Not tested

Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues

Phenotypes

decreased neutrophil cell number2 supporting datasetsSpata24tm1b(EUCOMM)WtsihomozygoteLate adult2.3x10-5 
decreased locomotor activity1 supporting datasetSpata24tm1b(EUCOMM)WtsihomozygoteLate adult9.19x10-5 
cataract1 supporting datasetSpata24tm1b(EUCOMM)WtsihomozygoteEarly adult5.87x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a50% (1/2)0.7% (4/570)
aortaheterozygoten/a0% (0/2)0.19% (1/533)
boneheterozygoten/a0% (0/2)0% (0/394)
brainheterozygoten/a100% (2/2)0.86% (5/579)
brainstemheterozygoten/a0% (0/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/a0% (0/2)0.22% (1/454)
cerebellumheterozygoten/a0% (0/2)0.56% (3/532)
cerebral cortexheterozygoten/a0% (0/2)0.41% (2/491)
esophagusheterozygoten/a0% (0/2)1.67% (7/419)
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Histopathology

IMPC related publications

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Spata24tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Spata24tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
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Spata24tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
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