Gpr15 | G protein-coupled receptor 15

GeneMGI:1918473Synonyms: 4933439K08Rik

Physiological systems

18 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Skeleton

12 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



decreased bone mineral content	2 supporting datasets	Gpr15^em1(IMPC)J	homozygote	Early adult	7.31x10^-7
increased total body fat amount	2 supporting datasets	Gpr15^em1(IMPC)J	homozygote	Early adult	1.29x10^-8
impaired glucose tolerance	1 supporting dataset	Gpr15^em1(IMPC)J	homozygote	Early adult	9.72x10^-6
decreased mean corpuscular hemoglobin	1 supporting dataset	Gpr15^em1(IMPC)J	homozygote	Early adult	3.59x10^-5
decreased mean corpuscular hemoglobin concentration	1 supporting dataset	Gpr15^em1(IMPC)J	homozygote	Early adult	1.14x10^-5
decreased lean body mass	2 supporting datasets	Gpr15^em1(IMPC)J	homozygote	Early adult	5.29x10^-7
abnormal startle reflex	1 supporting dataset	Gpr15^em1(IMPC)J	homozygote	Late adult	2.82x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gpr15.

Associated images

Download files

Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

4 images

Combined SHIRPA and Dysmorphology

Images

11 images

X-ray

XRay Images Forepaw

11 images

X-ray

XRay Images Skull Dorso Ventral Orientation

11 images

X-ray

XRay Images Skull Lateral Orientation

11 images

X-ray

XRay Images Whole Body Dorso Ventral

11 images

X-ray

XRay Images Whole Body Lateral Orientation

Human diseases caused by Gpr15 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.



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Histopathology

There is no histopathology data found for Gpr15.

IMPC related publications

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External links

No external links available for Gpr15.

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*Gpr15^em1(IMPC)Bay*	Exon Deletion	‌	mouse
*Gpr15^em1(IMPC)J*	Indel	‌	mouse

My Genes

Gpr15 | G protein-coupled receptor 15

Physiological systems

6 Significantly impacted by the knock-out

12 No significant impact

6 Not tested

Data collections

Phenotypes

lacZ Expression

Associated images

Auditory Brain Stem Response

Combined SHIRPA and Dysmorphology

X-ray

X-ray

X-ray

X-ray

X-ray

Human diseases caused by Gpr15 mutations

Histopathology

IMPC related publications

External links

Order Mouse and ES Cells

The IMPC Newsletter

Access Data Release 22.1 Data