Gene Summary

Name:
Rho guanine nucleotide exchange factor (GEF) 26
Synonyms:
4631416L12Rik,  8430436L14Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
enlarged lymph nodes Arhgef26em2(IMPC)Mbp HOM Early adult 0.00
abnormal lymph node morphology Arhgef26em2(IMPC)Mbp HOM Early adult 0.00

Download data as:  TSV  XLS

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Viewing: all phenotypes
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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

57 Images

X-ray

XRay Images Whole Body Lateral Orientation

19 Images

Human diseases caused by Arhgef26 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Arhgef26 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Immunodeficiency 32A
Lymphadenopathy OMIM:614893
Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Irf8 Deficiency
Lymphadenopathy ORPHA:319600
Immunodeficiency 38 With Basal Ganglia Calcification
Lymphadenopathy OMIM:616126
Reticuloendotheliosis, X-Linked
Lymphadenopathy, Hepatosplenomegaly OMIM:312500
Hepatic Venoocclusive Disease With Immunodeficiency
Absence of lymph node germinal center OMIM:235550
Squamous Cell Carcinoma Of The Esophagus
Lymphadenopathy ORPHA:99977
Pulmonary Nodular Lymphoid Hyperplasia
Mediastinal lymphadenopathy, Follicular hyperplasia ORPHA:60026
Fragile Site, Distamycin A Type, Rare, Fra(16)(Q22.1)
Abnormality of the lymph nodes OMIM:136580
Mantle Cell Lymphoma
Lymphadenopathy, Splenomegaly ORPHA:52416
Immunodeficiency 75
Lymphadenopathy, Hepatosplenomegaly, Follicular hyperplasia OMIM:619126
Kerion Celsi
Lymphadenopathy ORPHA:499
Kimura Disease
Lymphadenopathy, Follicular hyperplasia ORPHA:482
Immunodeficiency 7
Lymphadenopathy OMIM:615387
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Positive
Lymphadenopathy, Splenomegaly OMIM:608971
Adenocarcinoma Of The Esophagus
Lymphadenopathy ORPHA:99976
Deafness, Autosomal Dominant 34, With Or Without Inflammation
Lymphadenopathy OMIM:617772
Mast Cell Sarcoma
Lymphadenopathy, Mediastinal lymphadenopathy, Splenomegaly ORPHA:66661
Immunodeficiency 27B
Generalized lymphadenopathy OMIM:615978
Autoinflammation With Episodic Fever And Lymphadenopathy
Lymphadenopathy, Recurrent tonsillitis, Splenomegaly OMIM:618852
Immunodeficiency 63 With Lymphoproliferation And Autoimmunity
Lymphadenopathy, Splenomegaly OMIM:618495
Carcinoma Of Esophagus
Lymphadenopathy ORPHA:70482
Immunodeficiency With Hyper-Igm, Type 2
Lymphadenopathy OMIM:605258
Lymphoproliferative Syndrome 3
Lymphadenopathy, Hepatosplenomegaly OMIM:618261
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation
Absent tonsils, Aplasia of the thymus, Lymph node hypoplasia OMIM:602450
Follicular Lymphoma
Lymphadenopathy, Mediastinal lymphadenopathy, Splenomegaly ORPHA:545
Autoimmune Hemolytic Anemia-Autoimmune Thrombocytopenia-Primary Immunodeficiency Syndrome
Lymphadenopathy, Splenomegaly ORPHA:444463
Nodular Lymphocyte Predominant Hodgkin Lymphoma
Lymphadenopathy, Splenomegaly ORPHA:86893
Granulomatous Slack Skin
Abnormality of the lymph nodes ORPHA:33111
Immunodeficiency With Hyper-Igm, Type 5
Lymphadenopathy OMIM:608106
Candidiasis, Familial, 2
Lymphadenopathy OMIM:212050
Immunodeficiency 73C With Defective Neutrophil Chemotaxis And Hypogammaglobulinemia
Cervical lymphadenopathy OMIM:618987
Familial Papillary Thyroid Carcinoma With Renal Papillary Neoplasia
Chronic noninfectious lymphadenopathy, Abnormality of the lymph nodes ORPHA:97290
Polyglucosan Body Myopathy 1 With Or Without Immunodeficiency
Lymphadenopathy OMIM:615895
Familial Papillary Or Follicular Thyroid Carcinoma
Chronic noninfectious lymphadenopathy, Abnormality of the lymph nodes ORPHA:319487
Immunodeficiency 76
Lymphadenopathy, Splenomegaly OMIM:619164
Rosaï-Dorfman Disease
Lymphadenopathy ORPHA:158014
Fish-Eye Disease
Lymphadenopathy, Splenomegaly ORPHA:79292
Mu-Heavy Chain Disease
Lymphadenopathy, Splenomegaly ORPHA:100024
Immunodeficiency 72 With Autoinflammation
Lymphadenopathy, Hepatosplenomegaly OMIM:618982
Immunodeficiency 14A, Autosomal Dominant
Lymphadenopathy, Splenomegaly OMIM:615513
Hodgkin Lymphoma
Lymphadenopathy, Splenomegaly ORPHA:98293
Immunodeficiency With Hyper-Igm, Type 3
Absence of lymph node germinal center OMIM:606843
Immunodeficiency 78 With Autoimmunity And Developmental Delay
Fluctuating splenomegaly, Lymphadenopathy OMIM:619220
Immunodeficiency 55
Lymphadenopathy OMIM:617827
Mycosis Fungoides
Lymphadenopathy OMIM:254400
Burkitt Lymphoma
Abnormality of the spleen, Abnormality of the lymph nodes ORPHA:543
Laryngeal Neuroendocrine Tumor
Chronic noninfectious lymphadenopathy ORPHA:100083
Immunodeficiency With Hyper-Igm, Type 4
Absence of lymph node germinal center OMIM:608184
Alpha-Heavy Chain Disease
Lymphadenopathy, Splenomegaly ORPHA:100025
Pfapa Syndrome
Lymphadenopathy, Splenomegaly ORPHA:42642
Proteasome-Associated Autoinflammatory Syndrome 2
Lymphadenopathy OMIM:618048
Hemophagocytic Lymphohistiocytosis, Familial, 5, With Or Without Microvillus Inclusion Disease
Lymphadenopathy, Hepatosplenomegaly, Splenomegaly OMIM:613101
Immunodeficiency 64
Mediastinal lymphadenopathy, Lymphadenopathy, Splenomegaly, Hepatosplenomegaly, Cervical lymphade... OMIM:618534
Immunodeficiency 52
Lymphadenopathy, Splenomegaly OMIM:617514
Hemophagocytic Lymphohistiocytosis, Familial, 4
Lymphadenopathy, Splenomegaly OMIM:603552
Immunodeficiency, Common Variable, 2
Lymphadenopathy, Follicular hyperplasia, Splenomegaly OMIM:240500
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia
Lymphadenopathy, Mediastinal lymphadenopathy, Splenomegaly OMIM:300853
Leukocyte Adhesion Deficiency, Type Iii
Hepatosplenomegaly, Abnormality of the lymph nodes, Splenomegaly OMIM:612840
Autoimmune Lymphoproliferative Syndrome, Type Iii
Mediastinal lymphadenopathy, Lymphadenopathy, Splenomegaly, Hepatosplenomegaly, Generalized lymph... OMIM:615559
Immunodeficiency 27A
Lymphadenopathy, Hepatosplenomegaly, Enlarged mesenteric lymph node, Splenomegaly OMIM:209950
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Absent tonsils, Absence of lymph node germinal center ORPHA:277
Pseudomyxoma Peritonei
Lymphadenopathy ORPHA:26790
Familial Cold Autoinflammatory Syndrome 2
Lymphadenopathy, Splenomegaly OMIM:611762
Classic Mycosis Fungoides
Lymphadenopathy, Splenomegaly ORPHA:2584
Cold Agglutinin Disease
Lymphadenopathy, Splenomegaly ORPHA:56425
Schnitzler Syndrome
Lymphadenopathy, Splenomegaly ORPHA:37748
Caspase 8 Deficiency
Lymphadenopathy, Splenomegaly OMIM:607271
Pleural Mesothelioma
Lymphadenopathy ORPHA:50251
Middle Ear Neuroendocrine Tumor
Chronic noninfectious lymphadenopathy ORPHA:100084
Indolent Systemic Mastocytosis
Lymphadenopathy, Splenomegaly ORPHA:98848
Autoinflammatory Syndrome, Familial, With Or Without Immunodeficiency
Lymphadenopathy, Splenomegaly OMIM:619375
Immunodeficiency, Common Variable, 1
Lymphadenopathy, Splenomegaly OMIM:607594
Classic Hodgkin Lymphoma
Lymphadenopathy, Bone marrow hypocellularity, Splenomegaly ORPHA:391
Periodic Fever, Immunodeficiency, And Thrombocytopenia Syndrome
Lymphadenopathy, Splenomegaly OMIM:150550
Corticosteroid-Sensitive Aseptic Abscess Syndrome
Abnormality of the lymphatic system, Abnormality of the lymph nodes ORPHA:54251
Systemic-Onset Juvenile Idiopathic Arthritis
Lymphadenopathy, Splenomegaly ORPHA:85414
Immunodeficiency 54
Lymphadenopathy, Splenomegaly OMIM:609981
Tularemia
Lymphadenopathy, Abnormal nasopharyngeal adenoid morphology, Mediastinal lymphadenopathy, Cervica... ORPHA:3392
Immunodeficiency 10
Lymphadenopathy OMIM:612783
Ras-Associated Autoimmune Leukoproliferative Disorder
Follicular hyperplasia, Splenomegaly OMIM:614470
Congenital Toxoplasmosis
Lymphadenopathy ORPHA:858
Nephroblastoma
Lymphadenopathy ORPHA:654
Heme Oxygenase 1 Deficiency
Lymphadenopathy, Cervical lymphadenopathy, Asplenia OMIM:614034
Meige Disease
Absence of lymph node germinal center, Lymph node hypoplasia ORPHA:90186
Lymphoproliferative Syndrome 2
Lymphadenopathy, Hepatosplenomegaly, Splenomegaly OMIM:615122
Klatskin Tumor
Lymphadenopathy ORPHA:99978
Cinca Syndrome
Lymphadenopathy, Hepatosplenomegaly OMIM:607115
Omenn Syndrome
Lymphadenopathy, Hypoplasia of the thymus, Splenomegaly OMIM:603554
Squamous Cell Carcinoma Of The Anal Canal
Lymphadenopathy ORPHA:424019
Thyroid Lymphoma
Lymphadenopathy ORPHA:97285
Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia
Lymphadenopathy OMIM:617718
Griscelli Syndrome Type 2
Lymphadenopathy, Splenomegaly ORPHA:79477
Acquired Hypertrichosis Lanuginosa
Lymphadenopathy ORPHA:2221
Pyogenic Arthritis-Pyoderma Gangrenosum-Acne Syndrome
Lymphadenopathy ORPHA:69126
Rhabdoid Tumor
Lymphadenopathy ORPHA:69077
Proteasome-Associated Autoinflammatory Syndrome 4
Lymphadenopathy, Splenomegaly OMIM:619183
Combined Immunodeficiency Due To Zap70 Deficiency
Lymphadenopathy, Lymphadenitis, Hepatosplenomegaly, Abnormality of the lymph nodes ORPHA:911
Desmoplastic Small Round Cell Tumor
Lymphadenopathy, Mediastinal lymphadenopathy ORPHA:83469
Granulomatous Disease, Chronic, Autosomal Recessive, 5
Lymphadenopathy, Lymphadenitis, Splenomegaly, Hepatosplenomegaly, Recurrent tonsillitis OMIM:618935
Roifman Syndrome
Lymphadenopathy, Splenomegaly OMIM:616651
Autoimmune Lymphoproliferative Syndrome
Chronic noninfectious lymphadenopathy, Follicular hyperplasia, Splenomegaly OMIM:601859
Roifman Syndrome
Lymphadenopathy, Hepatosplenomegaly ORPHA:353298
Deafness-Lymphedema-Leukemia Syndrome
Lymphadenopathy, Bone marrow hypocellularity, Splenomegaly ORPHA:3226
Lymphoproliferative Syndrome, X-Linked, 1
Lymphadenopathy, Splenomegaly OMIM:308240
Leishmaniasis
Lymphadenopathy, Splenomegaly ORPHA:507
Boutonneuse Fever
Lymphadenopathy, Cervical lymphadenopathy ORPHA:83313
Melkersson-Rosenthal Syndrome
Lymphadenopathy ORPHA:2483
Pancreatoblastoma
Abnormality of the lymph nodes ORPHA:677
Medullary Thyroid Carcinoma
Lymphadenopathy ORPHA:1332
T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency
Absent tonsils, Lymph node hypoplasia ORPHA:276
Sézary Syndrome
Lymphadenopathy, Splenomegaly ORPHA:3162
Autoimmune Lymphoproliferative Syndrome, Type Iia
Lymphadenopathy, Chronic noninfectious lymphadenopathy, Follicular hyperplasia, Splenomegaly OMIM:603909
Pulmonary Non-Tuberculous Mycobacterial Infection
Lymphadenopathy ORPHA:411703
Griscelli Syndrome
Lymphadenopathy, Bone marrow hypocellularity, Splenomegaly ORPHA:381
Immune Dysregulation With Autoimmunity, Immunodeficiency, And Lymphoproliferation
Lymphadenopathy, Splenomegaly OMIM:616100
American Trypanosomiasis
Lymphadenopathy, Splenomegaly ORPHA:3386
Cyclic Neutropenia
Lymphadenopathy, Cervical lymphadenopathy, Recurrent tonsillitis ORPHA:2686
Scrub Typhus
Lymphadenopathy, Splenomegaly ORPHA:83317
Purine Nucleoside Phosphorylase Deficiency
Lymph node hypoplasia, Splenomegaly OMIM:613179
Immunodeficiency 91 And Hyperinflammation
Lymphadenopathy, Hepatosplenomegaly OMIM:619644
Primary Myelofibrosis
Lymphadenopathy, Hepatosplenomegaly, Splenomegaly ORPHA:824
Anaplastic Thyroid Carcinoma
Lymphadenopathy ORPHA:142
Thymic Neuroendocrine Tumor
Chronic noninfectious lymphadenopathy, Mediastinal lymphadenopathy, Neoplasm of the thymus ORPHA:97289
Diffuse Cutaneous Mastocytosis
Lymphadenopathy, Abnormality of the spleen ORPHA:79456
Combined Immunodeficiency Due To Crac Channel Dysfunction
Lymphadenopathy, Splenomegaly ORPHA:169090
Agammaglobulinemia, X-Linked
Lymph node hypoplasia OMIM:300755
Castleman Disease
Lymphadenopathy, Generalized lymphadenopathy, Mediastinal lymphadenopathy, Follicular hyperplasia ORPHA:160
Omenn Syndrome
Lymphadenopathy, Splenomegaly ORPHA:39041
Aggressive Systemic Mastocytosis
Lymphadenopathy, Hepatosplenomegaly, Hypersplenism ORPHA:98850
Felty Syndrome
Lymphadenopathy, Bone marrow hypocellularity, Splenomegaly ORPHA:47612
Cutaneous Neuroendocrine Carcinoma
Chronic noninfectious lymphadenopathy ORPHA:79140
Lymphoproliferative Syndrome 1
Lymphadenopathy, Splenomegaly OMIM:613011
Cinca Syndrome
Lymphadenopathy, Splenomegaly ORPHA:1451
Gamma-Heavy Chain Disease
Lymphadenopathy, Splenomegaly ORPHA:100026
Hereditary Amyloidosis With Primary Renal Involvement
Lymphadenopathy, Hepatosplenomegaly, Abnormality of the lymph nodes ORPHA:85450
Niemann-Pick Disease, Type A
Lymphadenopathy, Splenomegaly OMIM:257200
Immunodeficiency With Hyper-Igm, Type 1
Enlarged tonsils, Absence of lymph node germinal center, Splenomegaly OMIM:308230
Adult-Onset Still Disease
Generalized lymphadenopathy, Bone marrow hypocellularity, Splenomegaly ORPHA:829
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Lymphadenopathy, Hepatosplenomegaly ORPHA:169154
Macrophage Activation Syndrome
Lymphadenopathy, Splenomegaly ORPHA:158061
Hypocomplementemic Urticarial Vasculitis
Lymphadenopathy, Splenomegaly ORPHA:36412
Hyperimmunoglobulinemia D With Periodic Fever
Lymphadenopathy ORPHA:343
Legionnaires Disease
Lymphadenopathy, Bone marrow hypocellularity, Splenomegaly ORPHA:549
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity
Lymphadenopathy, Hepatosplenomegaly, Enlarged tonsils OMIM:606367
Mixed Connective Tissue Disease
Lymphadenopathy, Mediastinal lymphadenopathy, Splenomegaly ORPHA:809
Malt Lymphoma
Lymphadenopathy, Mediastinal lymphadenopathy ORPHA:52417
Pulmonary Capillary Hemangiomatosis
Lymphadenopathy, Mediastinal lymphadenopathy ORPHA:199241
Aregenerative Anemia
Lymphadenopathy, Bone marrow hypocellularity ORPHA:101096
Granulomatous Disease, Chronic, Autosomal Recessive, 1
Lymphadenopathy, Lymphadenitis, Splenomegaly OMIM:233700
Granulomatous Disease, Chronic, Autosomal Recessive, 2
Lymphadenopathy, Lymphadenitis, Splenomegaly OMIM:233710
Lig4 Syndrome
Lymphadenopathy ORPHA:99812
Immunodeficiency, Common Variable, 8, With Autoimmunity
Lymphadenopathy, Generalized lymphadenopathy, Splenomegaly OMIM:614700
Immunodeficiency 73B With Defective Neutrophil Chemotaxis And Lymphopenia
Lymphadenitis, Generalized lymphadenopathy, Hepatosplenomegaly OMIM:618986
Hyper-Igd Syndrome
Lymphadenopathy, Lymphadenitis, Hepatosplenomegaly, Splenomegaly OMIM:260920
Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked
Lymphadenopathy OMIM:304790
Acute Interstitial Pneumonia
Lymphadenopathy ORPHA:79126
Granulomatous Disease, Chronic, Autosomal Recessive, 4
Lymphadenopathy, Lymphadenitis, Splenomegaly OMIM:233690
Granulomatous Disease, Chronic, X-Linked
Lymphadenopathy, Lymphadenitis, Splenomegaly OMIM:306400
Familial Hemophagocytic Lymphohistiocytosis
Lymphadenopathy, Splenomegaly ORPHA:540
Autoinflammation, Panniculitis, And Dermatosis Syndrome
Lymphadenopathy OMIM:617099
Mevalonic Aciduria
Lymphadenopathy, Hepatosplenomegaly, Fluctuating splenomegaly OMIM:610377
Proteasome-Associated Autoinflammatory Syndrome 3
Lymphadenopathy, Splenomegaly OMIM:617591
Carney Triad
Lymphadenopathy, Mediastinal lymphadenopathy ORPHA:139411
Hemophagocytic Lymphohistiocytosis, Familial, 2
Lymphadenopathy, Hepatosplenomegaly, Splenomegaly OMIM:603553
Hemophagocytic Lymphohistiocytosis, Familial, 1
Lymphadenopathy, Splenomegaly OMIM:267700
Lymphatic Filariasis
Lymphadenopathy, Lymphadenitis, Lymphangiectasis, Abnormality of the lymphatic system ORPHA:2035
Pediatric Systemic Lupus Erythematosus
Lymphadenopathy ORPHA:93552
Familial Pancreatic Carcinoma
Lymphadenopathy, Hepatosplenomegaly ORPHA:1333
Drug Reaction With Eosinophilia And Systemic Symptoms
Lymphadenopathy ORPHA:139402
Acute Promyelocytic Leukemia
Lymphadenopathy ORPHA:520
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative
Absent peripheral lymph nodes in presence of infection OMIM:600802
Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
Hepatosplenomegaly, Absence of lymph node germinal center ORPHA:79124
Kikuchi-Fujimoto Disease
Lymphadenopathy, Abnormality of the lymph nodes, Splenomegaly, Generalized lymphadenopathy, Cervi... ORPHA:50918
Chediak-Higashi Syndrome
Lymphadenopathy, Splenomegaly OMIM:214500
Graft Versus Host Disease
Lymphadenopathy, Hepatosplenomegaly ORPHA:39812
Farber Disease
Lymphadenopathy, Hepatosplenomegaly ORPHA:333
Waldenström Macroglobulinemia
Lymphadenopathy, Splenomegaly ORPHA:33226
Cherubism
Submandibular lymph node enlargement OMIM:118400
Systemic Mastocytosis With Associated Hematologic Neoplasm
Lymphadenopathy, Splenomegaly ORPHA:98849
Histiocytosis-Lymphadenopathy Plus Syndrome
Lymphadenopathy, Hepatosplenomegaly, Cervical lymphadenopathy, Splenomegaly OMIM:602782
Common Variable Immunodeficiency
Lymphadenopathy, Splenomegaly ORPHA:1572
Poems Syndrome
Lymphadenopathy ORPHA:2905
Tangier Disease
Hepatosplenomegaly, Chronic noninfectious lymphadenopathy, Orange discolored tonsils ORPHA:31150
H Syndrome
Lymphadenopathy, Hepatosplenomegaly ORPHA:168569
Thymic Aplasia
Lymphadenopathy, Aplasia of the thymus ORPHA:83471
Q Fever
Lymphadenopathy, Hepatosplenomegaly, Splenomegaly ORPHA:781
Adenocarcinoma Of The Anal Canal
Lymphadenopathy ORPHA:424016
Gallbladder Neuroendocrine Tumor
Chronic noninfectious lymphadenopathy ORPHA:100086
Neurologic, Endocrine, And Pancreatic Disease, Multisystem, Infantile-Onset 2
Lymphadenopathy, Accessory spleen, Polysplenia, Splenomegaly OMIM:619418
Multiple Myeloma
Lymphadenopathy, Splenomegaly ORPHA:29073
Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis
Lymphadenopathy, Hepatosplenomegaly ORPHA:85408
Spondyloenchondrodysplasia With Immune Dysregulation
Lymphadenopathy OMIM:607944
Selective Igm Deficiency
Lymphadenopathy, Lymphadenitis ORPHA:331235
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
Lymphadenopathy, Hepatosplenomegaly, Bone marrow hypocellularity, Splenomegaly OMIM:615688
Lymphangioleiomyomatosis
Lymphadenopathy, Pulmonary lymphangiomyomatosis, Abnormality of the lymphatic system ORPHA:538
Hennekam Syndrome
Lymphadenopathy, Lymphangioma, Pulmonary lymphangiectasia, Splenomegaly ORPHA:2136
X-Linked Lymphoproliferative Disease
Lymphadenopathy, Bone marrow hypocellularity, Splenomegaly, Hepatosplenomegaly, Cervical lymphade... ORPHA:2442
Autoimmune Lymphoproliferative Syndrome
Lymphadenopathy, Bone marrow hypocellularity, Splenomegaly, Hypersplenism, Chronic noninfectious ... ORPHA:3261
Chédiak-Higashi Syndrome
Lymphadenopathy, Hepatosplenomegaly, Splenomegaly ORPHA:167
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome
Lymphadenopathy, Splenomegaly ORPHA:37042
Tumor Necrosis Factor Receptor 1 Associated Periodic Syndrome
Lymphadenopathy, Splenomegaly ORPHA:32960
Ileal Neuroendocrine Tumor
Lymphadenopathy ORPHA:100078
Jejunal Neuroendocrine Tumor
Lymphadenopathy ORPHA:100077
Familial Mediterranean Fever
Lymphadenopathy, Splenomegaly ORPHA:342
Coccidioidomycosis
Lymphadenopathy, Abnormality of the spleen, Mediastinal lymphadenopathy ORPHA:228123
Chikungunya
Lymphadenopathy, Cervical lymphadenopathy ORPHA:324625
Duodenal Neuroendocrine Tumor
Lymphadenopathy ORPHA:100076
Autosomal Recessive Malignant Osteopetrosis
Lymphadenopathy, Splenomegaly ORPHA:667
Igg4-Related Submandibular Gland Disease
Lymphadenopathy ORPHA:449432
Brucellosis
Lymphadenopathy, Hypersplenism, Splenomegaly ORPHA:1304
Igg4-Related Kidney Disease
Lymphadenopathy, Lymphadenitis ORPHA:449395
Behçet Disease
Lymphadenopathy, Splenomegaly ORPHA:117
Proteasome-Associated Autoinflammatory Syndrome 1
Lymphadenopathy, Splenomegaly OMIM:256040
Sarcoidosis
Lymphadenopathy, Abnormality of the lymph nodes ORPHA:797
Igg4-Related Dacryoadenitis And Sialadenitis
Lymphadenopathy ORPHA:79078
Igg4-Related Ophthalmic Disease
Lymphadenopathy ORPHA:449563
Primary Sjögren Syndrome
Lymphadenopathy ORPHA:289390
Crimean-Congo Hemorrhagic Fever
Lymphadenopathy, Splenomegaly ORPHA:99827
Marburg Hemorrhagic Fever
Lymphadenopathy ORPHA:99826
Immunodeficiency 82 With Systemic Inflammation
Lymphadenopathy, Follicular hyperplasia, Splenomegaly OMIM:619381
Blau Syndrome
Lymphadenopathy, Splenomegaly ORPHA:90340
Cushing Syndrome Due To Ectopic Acth Secretion
Abnormality of the lymph nodes, Neoplasm of the thymus ORPHA:99889
African Trypanosomiasis
Lymphadenopathy, Hepatosplenomegaly, Splenomegaly ORPHA:3385
Leptospirosis
Lymphadenopathy ORPHA:509

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Arhgef26

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Arhgef26.

No publications found that use IMPC mice or data for Arhgef26.

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MGI Allele Allele Type Produced
Arhgef26em2(IMPC)Mbp Exon Deletion Mice, Tissue
Arhgef26tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Arhgef26tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Arhgef26tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Arhgef26tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells

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