Gene: Nos1ap

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Name
nitric oxide synthase 1 (neuronal) adaptor protein
MGI ID
MGI:1917979
Synonyms
6330408P19Rik
Viability
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
hyperactivity Nos1aptm1b(KOMP)Wtsi HOM Early adult 2.69×10-06
abnormal optic disk morphology Nos1aptm1b(KOMP)Wtsi HOM   Early adult 1.42×10-05
tremors Nos1aptm1b(KOMP)Wtsi HET Early adult 2.28×10-05
increased vertical activity Nos1aptm1b(KOMP)Wtsi HOM   Early adult 2.63×10-06
decreased total retina thickness Nos1aptm1b(KOMP)Wtsi HOM Early adult 4.26×10-05
decreased bone mineral content Nos1aptm1b(KOMP)Wtsi HOM Early adult 4.30×10-06
decreased circulating alanine transaminase level Nos1aptm1b(KOMP)Wtsi HOM Early adult 8.49×10-07
abnormal urinary bladder morphology Nos1aptm1b(KOMP)Wtsi HOM Early adult 0.00
thick ventricular wall Nos1aptm1b(KOMP)Wtsi HOM   Early adult 1.13×10-05
abnormal retinal blood vessel morphology Nos1aptm1b(KOMP)Wtsi HOM Early adult 3.27×10-05

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (4/583) N/A
Aorta 2 No  (1/583)  (2/2) N/A
Bone 2 No N/A
Brain 2 No  (4/583)  (2/2)  Wholemount images
Brainstem 2 No  (2/583) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (1/583)  (2/2)  Wholemount images
Cerebellum 2 No  (3/583)  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/583)  (2/2)  Wholemount images
Esophagus 2 No  (7/407) N/A
Eye 2 No N/A
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (2/583)  (2/2)  Wholemount images
Hippocampus 2 No  (3/583)  (2/2)  Wholemount images
Hypothalamus 2 No  (2/583)  (2/2)  Wholemount images
Kidney 2 No  (21/583)  (2/2)  Wholemount images
Large intestine 2 No  (10/583) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (1/583)  (2/2)  Wholemount images
Lung 2 No  (2/583) N/A
Lymph node 2 No  (1/583) N/A
Mammary gland 2 No N/A
Mesenteric lymph node 2 No N/A
Olfactory lobe 2 No  (2/583)  (2/2)  Wholemount images
Oral epithelium 2 No N/A
Ovary 2 No  (1/583)  (1/2) N/A
Oviduct 2 No  Wholemount images
Pancreas 2 No  (5/583) N/A
Parathyroid gland 2 No  (1/563)  (2/2) N/A
Peripheral nervous system 2 No  (2/583) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/583) N/A
Prostate gland 2 No  (12/583)  (1/2)  Wholemount images
Skeletal muscle 2 No N/A
Skin 2 No  (1/583) N/A
Small intestine 2 No  (9/583) N/A
Spinal cord 2 No  (3/583)  (2/2)  Wholemount images
Spleen 2 No  (3/583) N/A
Stomach 2 No  (13/583) N/A
Striatum 2 No  (3/583) N/A
Testis 2 No  (6/583)  Wholemount images
Thymus 2 No  (1/583) N/A
Thyroid gland 2 No  (17/583)  (2/2) N/A
Trachea 2 No  (3/583)  (2/2)  Wholemount images
Urinary bladder 2 No N/A
Uterus 2 No N/A
Vas deferens 2 No  (15/382)  Wholemount images
Vascular system 2 No N/A
White adipose tissue 2 No N/A
No Embryo expression data was found for this gene.

 Associated Images

X-ray: XRay Images Whole Body Lateral Orientation
16 Images
X-ray: XRay Images Whole Body Dorso Ventral
16 Images
X-ray: XRay Images Forepaw
16 Images
Adult LacZ: LacZ Images Wholemount
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
16 Images
X-ray: XRay Images Skull Lateral Orientation
16 Images
Histopathology
1 Images

 Disease Models

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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Heart - hypertrophy Nos1aptm1b(KOMP)Wtsi HOM Early adult

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Nos1aptm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Nos1aptm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue

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