Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Adrenal gland | Wholemount images Section images | heterozygote | 83.33% (5 of 6) |
Aorta | Wholemount images Section images | heterozygote | 83.33% (5 of 6) |
Blood | Section images | heterozygote | 33.33% (2 of 6) |
Bone marrow | Section images | heterozygote | 16.67% (1 of 6) |
Brain | Wholemount images | heterozygote | 66.67% (4 of 6) |
Brown adipose tissue | Wholemount images Section images | heterozygote | 83.33% (5 of 6) |
Cecum | Section images | heterozygote | 100% (6 of 6) |
Cerebellum | Wholemount images Section images | heterozygote | 66.67% (4 of 6) |
Chest bone | Wholemount images | heterozygote | 16.67% (1 of 6) |
Colon | Wholemount images Section images | heterozygote | 100% (6 of 6) |
Diaphragm | Section images | heterozygote | 50% (3 of 6) |
Duodenum | Wholemount images Section images | heterozygote | 50% (3 of 6) |
Epididymis | Section images | heterozygote | 66.67% (4 of 6) |
Esophagus | Wholemount images Section images | heterozygote | 66.67% (4 of 6) |
Eye | Wholemount images Section images | heterozygote | 50% (3 of 6) |
Gall bladder | Wholemount images | heterozygote | 16.67% (1 of 6) |
Gonadal fat pad | Wholemount images Section images | heterozygote | 66.67% (4 of 6) |
Harderian gland | Wholemount images Section images | heterozygote | 66.67% (4 of 6) |
Ileum | Wholemount images Section images | heterozygote | 50% (3 of 6) |
Jejunum | Wholemount images Section images | heterozygote | 83.33% (5 of 6) |
Kidney | Wholemount images Section images | heterozygote | 83.33% (5 of 6) |
Liver | Wholemount images Section images | heterozygote | 83.33% (5 of 6) |
Lung | Wholemount images Section images | heterozygote | 66.67% (4 of 6) |
Mesenteric adipose tissue | Wholemount images Section images | heterozygote | 50% (3 of 6) |
Mesenteric lymph node | Wholemount images Section images | heterozygote | 33.33% (2 of 6) |
Midbrain | Wholemount images Section images | heterozygote | 66.67% (4 of 6) |
Olfactory lobe | Wholemount images Section images | heterozygote | 66.67% (4 of 6) |
Ovary | Section images | heterozygote | 16.67% (1 of 6) |
Oviduct | Section images | heterozygote | 16.67% (1 of 6) |
Pancreas | Wholemount images Section images | heterozygote | 66.67% (4 of 6) |
Parotid gland | Section images | heterozygote | 50% (3 of 6) |
Penis | Section images | heterozygote | 50% (3 of 6) |
Prostate gland | Wholemount images Section images | heterozygote | 50% (3 of 6) |
Quadriceps | Wholemount images Section images | heterozygote | 83.33% (5 of 6) |
Sciatic nerve | Wholemount images Section images | heterozygote | 66.67% (4 of 6) |
Skin | Wholemount images Section images | heterozygote | 83.33% (5 of 6) |
Spinal cord | Wholemount images Section images | heterozygote | 83.33% (5 of 6) |
Spleen | Wholemount images Section images | heterozygote | 66.67% (4 of 6) |
Stomach | Wholemount images Section images | heterozygote | 100% (6 of 6) |
Sublingual gland | Section images | heterozygote | 33.33% (2 of 6) |
Submandibular gland | Section images | heterozygote | 50% (3 of 6) |
Testis | Section images | heterozygote | 50% (3 of 6) |
Thymus | Wholemount images Section images | heterozygote | 83.33% (5 of 6) |
Thyroid gland | Wholemount images Section images | heterozygote | 66.67% (4 of 6) |
Tongue | Wholemount images Section images | heterozygote | 83.33% (5 of 6) |
Trachea | Wholemount images Section images | heterozygote | 83.33% (5 of 6) |
Trigeminal V nerve | Section images | heterozygote | 66.67% (4 of 6) |
Urinary bladder | Wholemount images Section images | heterozygote | 66.67% (4 of 6) |
Uterus | Section images | heterozygote | 16.67% (1 of 6) |
Vagina | Section images | heterozygote | 16.67% (1 of 6) |
Vas deferens | Section images | heterozygote | 66.67% (4 of 6) |
Vesicular gland | Wholemount images Section images | heterozygote | 66.67% (4 of 6) |
Brainstem | N/A | heterozygote | Not available |
Cartilage tissue | N/A | heterozygote | Not available |
Cerebral cortex | N/A | heterozygote | Not available |
Heart | N/A | heterozygote | Not available |
Hindlimb | N/A | heterozygote | Not available |
Hippocampus | N/A | heterozygote | Not available |
Hypothalamus | N/A | heterozygote | Not available |
Large intestine | N/A | heterozygote | 100% (6 of 6) |
Lower urinary tract | N/A | heterozygote | Not available |
Lymph node | N/A | heterozygote | Not available |
Mammary gland | N/A | heterozygote | 0.0% (0 of 6) |
Parathyroid gland | N/A | heterozygote | Not available |
Peripheral nervous system | N/A | heterozygote | Not available |
Peyer's patch | N/A | heterozygote | Not available |
Pituitary gland | N/A | heterozygote | 0.0% (0 of 6) |
Skeletal muscle | N/A | heterozygote | Not available |
Small intestine | N/A | heterozygote | 83.33% (5 of 6) |
Stomach pyloric region | N/A | heterozygote | Not available |
Striatum | N/A | heterozygote | Not available |
Vascular system | N/A | heterozygote | Not available |
White adipose tissue | N/A | heterozygote | Not available |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|---|
adrenal gland | 0.0% |
aorta | 0.0% |
blood | |
bone marrow | |
brain | 0.0% |
brainstem | 0.0% |
brown adipose tissue | 0.0% |
cartilage tissue | 0.0% |
cecum | 0.0% |
cerebellum | 0.0% |
cerebral cortex | 0.0% |
chest bone | |
colon | |
diaphragm | 0.0% |
duodenum | 0.0% |
epididymis | Unavailable |
esophagus | 0.0% |
eye | 0.0% |
gall bladder | 0.0% |
gonadal fat pad | 0.0% |
harderian gland | |
heart | 0.0% |
hindlimb | 0.0% |
hippocampus | 0.0% |
hypothalamus | 0.0% |
ileum | 0.0% |
jejunum | |
kidney | 0.0% |
large intestine | 0.0% |
liver | 0.0% |
lower urinary tract | 0.0% |
lung | 0.0% |
lymph node | 0.0% |
mammary gland | 0.0% |
mesenteric adipose tissue | 0.0% |
mesenteric lymph node | |
midbrain | 0.0% |
olfactory lobe | 0.0% |
ovary | 0.0% |
oviduct | 0.0% |
pancreas | 0.0% |
parathyroid gland | 0.0% |
parotid gland | 0.0% |
penis | 0.0% |
peripheral nervous system | 0.0% |
peyers patch | 0.0% |
pituitary gland | 0.0% |
prostate gland | 0.0% |
quadriceps | 0.0% |
sciatic nerve | 0.0% |
skeletal muscle | 0.0% |
skin | 0.0% |
small intestine | 0.0% |
spinal cord | 0.0% |
spleen | 0.0% |
stomach | 0.0% |
stomach pyloric region | 0.0% |
striatum | 0.0% |
sublingual gland | 0.0% |
submandibular gland | 0.0% |
testis | 0.0% |
thymus | 0.0% |
thyroid gland | 0.0% |
tongue | 0.0% |
trachea | 0.0% |
trigeminal v nerve | 0.0% |
urinary bladder | |
uterus | 0.0% |
vagina | 0.0% |
vas deferens | Unavailable |
vascular system | 0.0% |
vesicular gland | Unavailable |
white adipose tissue | 0.0% |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Inf2 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Focal Segmental Glomerulosclerosis 5 | Hypertension | OMIM:613237 | |
Charcot-Marie-Tooth Disease, Dominant Intermediate E | OMIM:614455 | ||
Genetic Steroid-Resistant Nephrotic Syndrome | ORPHA:656 |
The table below shows human diseases predicted to be associated to Inf2 by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Inf2.
There are 2 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcome. | eLife (January 2018) | Inf2tm1.1(KOMP)Vlcg | PMC5758111 |
Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. | PLoS genetics (February 2016) | Inf2tm1(KOMP)Vlcg | PMC4739719 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Inf2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | Mice, ES Cells |
Inf2tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | Mice, Tissue |
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