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Genes Phenotypes Help, News, Blog

Gene: Polr3b MGI:1917678

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Gene Summary

Name:
polymerase (RNA) III (DNA directed) polypeptide B
Synonyms:
A330032P03Rik,  RPC2,  2700078H01Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Polr3bem7(IMPC)Tcp HOM   Early adult 0.00
embryonic lethality prior to tooth bud stage Polr3bem7(IMPC)Tcp HOM   E12.5 0.00
embryonic lethality prior to organogenesis Polr3bem7(IMPC)Tcp HOM   E9.5 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Gross Pathology and Tissue Collection

Images

8 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

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X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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Immunophenotyping

Panel A FCS file(s)

6 Images

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X-ray

XRay Images Skull Lateral Orientation

10 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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Immunophenotyping

Panel B FCS file(s)

6 Images

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Human diseases caused by Polr3b mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Polr3b by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Hypomyelination-Hypogonadotropic Hypogonadism-Hypodontia Syndrome
ORPHA:88637
Leukodystrophy, Hypomyelinating, 8, With Or Without Oligodontia And/Or Hypogonadotropic Hypogonadism
OMIM:614381
Charcot-Marie-Tooth Disease, Demyelinating, Type 1I
OMIM:619742

The table below shows human diseases predicted to be associated to Polr3b by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Hypomyelination-Hypogonadotropic Hypogonadism-Hypodontia Syndrome
ORPHA:88637
Leukodystrophy, Hypomyelinating, 8, With Or Without Oligodontia And/Or Hypogonadotropic Hypogonadism
OMIM:614381
Charcot-Marie-Tooth Disease, Demyelinating, Type 1I
OMIM:619742

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Polr3b

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Polr3b.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Polr3b heterozygosity in mice induces both beneficial and deleterious effects on health during ageing with no effect on lifespan. Aging cell (March 2024) Polr3bem7(IMPC)Tcp 38465473

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Polr3bem7(IMPC)Tcp Indel Mice, Tissue
Polr3btm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Polr3btm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Polr3bem2(IMPC)Tcp Indel Mice

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