Rnf168 | ring finger protein 168
Physiological systems
21 / 24 physiological systems tested
12 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Pigmentation Integument Endocrine/exocrine gland Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Craniofacial
9 No significant impact
3 Not tested
Data collections
Gene metrics:31Significant phenotypes
2Associated diseases
Expression examined in:78Adult tissues
27Embryo tissues
abnormal thymus morphology | 2 supporting datasets | Rnf168tm2b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
increased grip strength | 2 supporting datasets | Rnf168em1(IMPC)H | homozygote | Early adult | 5.35x10-6 | ||
cornea opacity | 1 supporting dataset | Rnf168em1(IMPC)H | homozygote | Early adult | 2.56x10-5 | ||
increased mean platelet volume | 1 supporting dataset | Rnf168tm2b(EUCOMM)Hmgu | homozygote | Early adult | 9.35x10-7 | ||
abnormal skin morphology | 2 supporting datasets | Rnf168tm2b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
abnormal heart morphology | 1 supporting dataset | Rnf168tm2b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
increased grip strength | 1 supporting dataset | Rnf168tm2b(EUCOMM)Hmgu | homozygote | Early adult | 7.79x10-5 | ||
abnormal eye morphology | 2 supporting datasets | Rnf168tm2b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
decreased body weight | 1 supporting dataset | Rnf168tm2b(EUCOMM)Hmgu | homozygote | Early adult | 1.1x10-18 | ||
anophthalmia | 2 supporting datasets | Rnf168tm2b(EUCOMM)Hmgu | homozygote | Early adult | N/A * |
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External links
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Rnf168em1(IMPC)H | Exon Deletion | | mouse |
Rnf168em2(IMPC)H | Exon Deletion | | mouse |
Rnf168tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
Rnf168tm2b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
Rnf168tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |