Rnf168 | ring finger protein 168

GeneMGI:1917488Synonyms: 3110001H15Rik

Physiological systems

21 / 24 physiological systems tested

12 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Pigmentation Integument Endocrine/exocrine gland Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Craniofacial

9 No significant impact

3 Not tested

Gene metrics:31Significant phenotypes
2Associated diseases
Expression examined in:78Adult tissues
27Embryo tissues

Phenotypes

abnormal thymus morphology2 supporting datasetsRnf168tm2b(EUCOMM)HmguhomozygoteEarly adultN/A * 
increased grip strength2 supporting datasetsRnf168em1(IMPC)HhomozygoteEarly adult5.35x10-6 
cornea opacity1 supporting datasetRnf168em1(IMPC)HhomozygoteEarly adult2.56x10-5 
increased mean platelet volume1 supporting datasetRnf168tm2b(EUCOMM)HmguhomozygoteEarly adult9.35x10-7 
abnormal skin morphology2 supporting datasetsRnf168tm2b(EUCOMM)HmguhomozygoteEarly adultN/A * 
abnormal heart morphology1 supporting datasetRnf168tm2b(EUCOMM)HmguhomozygoteEarly adultN/A * 
increased grip strength1 supporting datasetRnf168tm2b(EUCOMM)HmguhomozygoteEarly adult7.79x10-5 
abnormal eye morphology2 supporting datasetsRnf168tm2b(EUCOMM)HmguhomozygoteEarly adultN/A * 
decreased body weight1 supporting datasetRnf168tm2b(EUCOMM)HmguhomozygoteEarly adult1.1x10-18 
anophthalmia2 supporting datasetsRnf168tm2b(EUCOMM)HmguhomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Rnf168em1(IMPC)HExon Deletionmouse
Rnf168em2(IMPC)HExon Deletionmouse
Rnf168tm2a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Rnf168tm2b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Rnf168tm2e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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