Gene: Dnmbp

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Name
dynamin binding protein
MGI ID
MGI:1917352
Synonyms
2410003M15Rik Tuba 2410003L07Rik
Viability
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal optic disk morphology Dnmbpem1(IMPC)Mbp HOM Late adult 4.03×10-14
enlarged seminal vesicle Dnmbpem1(IMPC)Mbp HOM Late adult 0.00
decreased circulating glucose level Dnmbpem1(IMPC)Mbp HOM Late adult 2.94×10-05
abnormal kidney morphology Dnmbpem1(IMPC)Mbp HOM Late adult 0.00
enlarged spleen Dnmbpem1(IMPC)Mbp HOM Late adult 0.00
absent seminal vesicle Dnmbpem1(IMPC)Mbp HOM Late adult 0.00
abnormal auditory brainstem response Dnmbpem1(IMPC)Mbp HOM   Early adult 3.42×10-06
increased prepulse inhibition Dnmbpem1(IMPC)Mbp HOM Early adult 3.31×10-08
small kidney Dnmbpem1(IMPC)Mbp HOM Late adult 0.00
abnormal spleen morphology Dnmbpem1(IMPC)Mbp HOM Late adult 0.00
abnormal liver morphology Dnmbpem1(IMPC)Mbp HOM Late adult 0.00
small heart Dnmbpem1(IMPC)Mbp HOM Late adult 0.00
abnormal heart morphology Dnmbpem1(IMPC)Mbp HOM Late adult 0.00
abnormal retinal vasculature morphology Dnmbpem1(IMPC)Mbp HOM Late adult 8.48×10-21
abnormal retinal blood vessel morphology Dnmbpem1(IMPC)Mbp HOM Late adult 8.48×10-21
persistence of hyaloid vascular system Dnmbpem1(IMPC)Mbp HOM Late adult 4.31×10-11
abnormal skin morphology Dnmbpem1(IMPC)Mbp HOM Late adult 0.00
decreased startle reflex Dnmbpem1(IMPC)Mbp HOM Early adult 1.11×10-07
decreased circulating bilirubin level Dnmbpem1(IMPC)Mbp HOM Early adult 1.67×10-07

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 Expression

Expression data not available

 Associated Images

X-ray: XRay Images Whole Body Lateral Orientation
12 Images
X-ray: XRay Images Whole Body Dorso Ventral
37 Images
X-ray: XRay Images Whole Body Dorso Ventral
27 Images
X-ray: XRay Images Whole Body Lateral Orientation
9 Images

 Disease Models

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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Eye with optic nerve - extracellular matrix deposition Dnmbpem1(IMPC)Mbp HOM Early adult
Uterus - extracellular matrix deposition Dnmbpem1(IMPC)Mbp HOM Early adult
Uterus - intracellular and extracellular accumulation Dnmbpem1(IMPC)Mbp HOM Early adult
Eye with optic nerve - hypertrophy Dnmbpem1(IMPC)Mbp HOM Early adult
Ear - inflammation Dnmbpem1(IMPC)Mbp HOM Early adult

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Dnmbptm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Dnmbptm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Dnmbpem1(IMPC)Mbp Exon Deletion Mice, Tissue

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