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Gene: Rasip1 MGI:1917153

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
Ras interacting protein 1
Synonyms:
Rain,  2610025P08Rik

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Rasip1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Rasip1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Congenital Heart Block
First degree atrioventricular block, Gallop rhythm, Pericardial effusion, Congestive heart failur... ORPHA:60041
Acute Peripheral Arterial Occlusion
Myocardial infarction, Abnormal capillary physiology, Absent ankle pulse, Pallor, Supraventricula... ORPHA:90064
Hb Bart'S Hydrops Fetalis
Pericarditis, Polyhydramnios, Congestive heart failure, Hydrops fetalis, Pallor, Oligohydramnios ORPHA:163596
Hereditary Persistence Of Fetal Hemoglobin-Beta-Thalassemia Syndrome
Pallor ORPHA:46532
Methylmalonic Acidemia With Homocystinuria, Type Cbld
Pallor ORPHA:79283
Peripheral Cone Dystrophy
Pallor OMIM:609021
Cone-Rod Dystrophy 11
Pallor OMIM:610381
Thiamine-Responsive Megaloblastic Anemia Syndrome
Ventricular septal defect, Cardiac arrest, Paroxysmal atrial tachycardia, Congestive heart failur... ORPHA:49827
Optic Atrophy 7 With Or Without Auditory Neuropathy
Hypertrophic cardiomyopathy, Pallor OMIM:612989
Optic Atrophy 1
Pallor OMIM:165500
American Trypanosomiasis
Edema, Periorbital edema, Myocarditis, Congestive heart failure, Cardiomyopathy, Pallor, Arrhythmia ORPHA:3386
Dermatitis, Atopic
Dry skin, Pallor, Facial erythema OMIM:603165
Hyperinsulinism Due To Ucp2 Deficiency
Tachycardia, Syncope, Palpitations, Pallor, Hypertrophic cardiomyopathy ORPHA:276556
Benign Paroxysmal Torticollis Of Infancy
Pallor ORPHA:71518
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Tachycardia, Syncope, Palpitations, Pallor, Hypertrophic cardiomyopathy ORPHA:276575
Myopathy, Lactic Acidosis, And Sideroblastic Anemia 2
Hypertrophic cardiomyopathy, Pallor OMIM:613561
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Tachycardia, Syncope, Palpitations, Pallor, Hypertrophic cardiomyopathy ORPHA:276580
Osteoporosis-Oculocutaneous Hypopigmentation Syndrome
Pallor ORPHA:2786
Breath-Holding Spells
Pallor OMIM:607578
Transaldolase Deficiency
Edema, Hydrops fetalis, Coarctation of aorta, Telangiectasia, Biventricular hypertrophy, Atrial s... ORPHA:101028
Leber Congenital Amaurosis 14
Pallor OMIM:613341
Rheumatic Fever
Pericarditis, Abnormal heart valve morphology, Epistaxis, Myocarditis, Erythema, Endocarditis, Ab... ORPHA:3099
Evans Syndrome
Pallor, Syncope, Epistaxis, Petechiae ORPHA:1959
Non-Functioning Paraganglioma
Cerebral hemorrhage, Congestive heart failure, Palpitations, Pallor, Positive regitine blocking t... ORPHA:94080
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Tachycardia, Pallor ORPHA:276608
Spontaneous Periodic Hypothermia
Arrhythmia, Pallor ORPHA:29822
Cyclic Vomiting Syndrome
Cardiomyopathy, Pallor OMIM:500007
Hyperinsulinism Due To Hnf1A Deficiency
Tachycardia, Syncope, Palpitations, Pallor ORPHA:324575
Hemoglobin D Disease
Pallor ORPHA:90039
Acute Myelomonocytic Leukemia
Pallor ORPHA:517
Primary Lateral Sclerosis, Juvenile
Pallor OMIM:606353
Deafness-Lymphedema-Leukemia Syndrome
Intracranial hemorrhage, Pallor, Lymphedema ORPHA:3226
Familial Focal Epilepsy With Variable Foci
Pallor ORPHA:98820
X-Linked Sideroblastic Anemia
Pallor ORPHA:75563
Kcnq2-Related Epileptic Encephalopathy
Pallor, Cerebral edema, Facial erythema ORPHA:439218
Waldenström Macroglobulinemia
Gastrointestinal hemorrhage, Epistaxis, Periorbital edema, Congestive heart failure, Vasculitis, ... ORPHA:33226
Drug-Induced Autoimmune Hemolytic Anemia
Congestive heart failure, Tachycardia, Pallor ORPHA:90037
Pulmonary Edema Of Mountaineers, Susceptibility To
Elevated pulmonary artery pressure, Edema, Pulmonary edema OMIM:178400
Beta-Thalassemia
Hypertrophic cardiomyopathy, Pallor, Skin ulcer ORPHA:848
Idiopathic Pulmonary Hemosiderosis
Cardiomegaly, Pallor, Heart murmur, Diffuse alveolar hemorrhage ORPHA:99931
Pyruvate Kinase Deficiency Of Red Cells
Intrauterine growth retardation, Pallor, Nonimmune hydrops fetalis OMIM:266200
Generalized Juvenile Polyposis/Juvenile Polyposis Coli
Hematochezia, Anemic pallor, Edema ORPHA:329971
Retinitis Pigmentosa 51
Pallor OMIM:613464
Histiocytoid Cardiomyopathy
Wolff-Parkinson-White syndrome, Atrial flutter, Tachycardia, Atrial fibrillation, Ventricular sep... ORPHA:137675
Beta-Ketothiolase Deficiency
Edema, Dehydration, Hypertension, Pallor, Hypotension ORPHA:134
Refractory Anemia With Excess Blasts
Palpitations, Anemic pallor, Retinal hemorrhage, Pedal edema ORPHA:86839
Lymphatic Malformation 7
Nonimmune hydrops fetalis, Edema, Lymphedema, Facial edema, Pericardial effusion, Increased nucha... OMIM:617300
Sepsis In Premature Infants
Tachycardia, Edema, Pallor, Bradycardia, Hypotension, Petechiae, Purpura ORPHA:90051
Primary Myelofibrosis
Portal hypertension, Pallor, Ecchymosis, Petechiae, Purpura ORPHA:824
Fanconi Anemia, Complementation Group I
Ventricular septal defect, Pallor, Atrial septal defect, Intrauterine growth retardation, Patent ... OMIM:609053
Myopathic Ehlers-Danlos Syndrome
Pallor ORPHA:536516
Sporadic Pheochromocytoma/Secreting Paraganglioma
Cerebral hemorrhage, Congestive heart failure, Palpitations, Pallor, Positive regitine blocking t... ORPHA:276621
Anemia, Congenital Dyserythropoietic, Type Ib
Pallor OMIM:615631
Autoimmune Hemolytic Anemia, Warm Type
Congestive heart failure, Tachycardia, Pallor ORPHA:90033
Leishmaniasis
Pallor, Skin ulcer ORPHA:507
Mixed-Type Autoimmune Hemolytic Anemia
Tachycardia, Pallor ORPHA:90036
Acquired Idiopathic Sideroblastic Anemia
Congestive heart failure, Pallor ORPHA:75564
Dravet Syndrome
Pallor ORPHA:33069
3-Hydroxy-3-Methylglutaric Aciduria
Cardiac arrest, Edema, Dilated cardiomyopathy, Dehydration, Pallor, Hypotension ORPHA:20
Irida Syndrome
Pallor ORPHA:209981
Myelofibrosis
Pallor, Purpura OMIM:254450
Congenital Total Pulmonary Venous Return Anomaly
Atrial situs ambiguous, Cardiomegaly, Mixed total anomalous pulmonary venous connection, Pallor, ... ORPHA:99125
Megaloblastic Anemia Due To Dihydrofolate Reductase Deficiency
Pallor OMIM:613839
Renal Tubular Acidosis, Distal, 4, With Hemolytic Anemia
Pallor OMIM:611590
Congenital Hyperinsulinism Due To Hnf4A Deficiency
Tachycardia, Pallor ORPHA:263455
Hereditary Pheochromocytoma-Paraganglioma
Cerebral hemorrhage, Congestive heart failure, Palpitations, Pallor, Positive regitine blocking t... ORPHA:29072
Myopathy, Lactic Acidosis, And Sideroblastic Anemia 1
Pallor OMIM:600462
Aneurysm Of Sinus Of Valsalva
Aortic regurgitation, Edema, Congestive heart failure, Heart murmur, Bacterial endocarditis, Dila... ORPHA:1054
3-Hydroxy-3-Methylglutaryl-Coa Lyase Deficiency
Pallor OMIM:246450
Cold Agglutinin Disease
Pallor ORPHA:56425
Congenital Dyserythropoietic Anemia Type Iii
Melena, Pallor ORPHA:98870
Beta-Thalassemia Intermedia
High-output congestive heart failure, Pallor, Pulmonary arterial hypertension, Skin ulcer ORPHA:231222
Idiopathic Hypereosinophilic Syndrome
Transient ischemic attack, Supraventricular arrhythmia, Pulmonary embolism, Raynaud phenomenon, C... ORPHA:3260
Von Hippel-Lindau Disease
Myocardial infarction, Myocarditis, Macular edema, Abnormal left ventricular function, Cardiomyop... ORPHA:892
6-Pyruvoyl-Tetrahydropterin Synthase Deficiency
Pallor ORPHA:13
Dominant Beta-Thalassemia
High-output congestive heart failure, Dilated cardiomyopathy, Skin ulcer, Pallor, Arrhythmia ORPHA:231226
Anemia, Hypochromic Microcytic, With Iron Overload 2
Pallor OMIM:615234
Retinitis Pigmentosa 75
Pallor OMIM:617023
Alternating Hemiplegia Of Childhood
Cardiac conduction abnormality, Dehydration, Cardiomyopathy, Pallor, Abnormal T-wave, Arrhythmia ORPHA:2131
Anemia, Sideroblastic, 1
Anemic pallor OMIM:300751
Hereditary Spherocytosis
Restrictive cardiomyopathy, Pallor, Skin ulcer ORPHA:822
Cardiac Valvular Dysplasia 1
Edema, Hydrops fetalis, Atrial septal defect, Pulmonary artery atresia, Patent foramen ovale, Tri... OMIM:212093
Fumarase Deficiency
Perimembranous ventricular septal defect, Ascites, Pallor, Polyhydramnios OMIM:606812
Fructose-1,6-Bisphosphatase Deficiency
Tachycardia, Pallor ORPHA:348
Tay-Sachs Disease
Pallor OMIM:272800
Cone-Rod Dystrophy 8
Pallor OMIM:605549
Beta-Thalassemia Major
High-output congestive heart failure, Dilated cardiomyopathy, Skin ulcer, Pallor, Arrhythmia ORPHA:231214
Infection-Related Hemolytic Uremic Syndrome
Edema, Myocarditis, Hypertension, Pleural empyema, Pallor, Hypertensive crisis, Generalized edema ORPHA:544482
Diamond-Blackfan Anemia 1
Ventricular septal defect, Tricuspid stenosis, Congestive heart failure, Coarctation of aorta, Pa... OMIM:105650
Systemic Mastocytosis With Associated Hematologic Neoplasm
Tachycardia, Syncope, Pallor, Hypotension ORPHA:98849
Elliptocytosis 1
Pallor OMIM:611804
Sheehan Syndrome
Orthostatic hypotension, Palpitations, Bradycardia, Pallor, Dry skin ORPHA:91355
Esophageal Atresia
Ventricular septal defect, Polyhydramnios, Coarctation of aorta, Pallor, Tetralogy of Fallot ORPHA:1199
Imerslund-Gräsbeck Syndrome
Tachycardia, Pallor ORPHA:35858
Senior-Loken Syndrome 8
Pallor OMIM:616307
Pituitary Apoplexy
Hypertension, Pallor, Hypotension ORPHA:95613
Plummer-Vinson Syndrome
Pallor ORPHA:54028
Childhood Absence Epilepsy
Pallor ORPHA:64280
Pearson Marrow-Pancreas Syndrome
Pallor, Erythema, Hydrops fetalis, Dehydration OMIM:557000
Non-Functioning Pituitary Adenoma
Pallor, Hypotension ORPHA:91349
Myopathy, Mitochondrial, And Ataxia
Pallor OMIM:617675
Tsh-Secreting Pituitary Adenoma
Supraventricular arrhythmia, Pericardial effusion, Congestive heart failure, Hypertension, Palpit... ORPHA:91347
Letterer-Siwe Disease
Pallor OMIM:246400
Adenohypophysitis
Orthostatic hypotension, Pallor ORPHA:95512
Hereditary Folate Malabsorption
Pallor ORPHA:90045
Panhypophysitis
Orthostatic hypotension, Pallor ORPHA:95513
Diamond-Blackfan Anemia
Ventricular septal defect, Nonimmune hydrops fetalis, Abnormal heart morphology, Coarctation of a... ORPHA:124
Prolactinoma
Pallor, Hypotension ORPHA:2965
Degcags Syndrome
Tachycardia, Ventricular septal defect, Polyhydramnios, Patent ductus arteriosus, Pulmonary arter... OMIM:619488
Severe Combined Immunodeficiency Due To Complete Rag1/2 Deficiency
Pallor ORPHA:331206
Severe Congenital Hypochromic Anemia With Ringed Sideroblasts
Pallor ORPHA:300298
Autosomal Recessive Malignant Osteopetrosis
Abnormal pulmonary valve morphology, Pulmonary arterial hypertension, Pulmonary artery stenosis, ... ORPHA:667
Incontinentia Pigmenti
Pallor, Erythema, Retinal hemorrhage OMIM:308300
Aregenerative Anemia
Pallor ORPHA:101096
Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema
Pallor OMIM:194380
Anemia, Nonspherocytic Hemolytic, Due To G6Pd Deficiency
Pallor OMIM:300908
Retinitis Pigmentosa And Erythrocytic Microcytosis
Pallor OMIM:616959
Fanconi Anemia, Complementation Group D2
Patent ductus arteriosus, Anemic pallor, Abnormal heart morphology OMIM:227646
Fanconi Anemia, Complementation Group C
Intrauterine growth retardation, Ventricular septal defect, Anemic pallor OMIM:227645
Fanconi Anemia, Complementation Group E
Anemic pallor, Abnormal heart morphology OMIM:600901
Multiple Endocrine Neoplasia Type 2
Pallor, Palpitations, Hypertensive crisis, Hypertension associated with pheochromocytoma ORPHA:653
Fanconi Anemia, Complementation Group A
Anemic pallor, Abnormal heart morphology OMIM:227650
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 3
Pallor OMIM:253280
Goodpasture Syndrome
Pallor, Pulmonary hemorrhage OMIM:233450

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Rasip1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Rasip1.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Rasip1 is essential to blood vessel stability and angiogenic blood vessel growth. Angiogenesis (February 2016) Rasip1tm3a(EUCOMM)Wtsi PMC4808411

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Rasip1tm3a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Rasip1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Rasip1tm2e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Rasip1tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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