The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Tprkb by orthology or direct annotation.
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|MGI Allele||Allele Type||Produced|
|Tprkbtm1e(EUCOMM)Wtsi||Targeted, non-conditional allele||ES Cells|
|Tprkbtm1(KOMP)Vlcg||Reporter-tagged deletion allele (with selection cassette)||ES Cells|
|Tprkbtm1a(EUCOMM)Wtsi||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors, ES Cells|