Gene Summary

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
embryonic lethality prior to organogenesis Cadem1(IMPC)Mbp HOM   E9.5 0.00
decreased prepulse inhibition Cadem1(IMPC)Mbp HET Early adult 2.52×10-05
limb grasping Cadem1(IMPC)Mbp HET   Early adult 3.01×10-05
preweaning lethality, complete penetrance Cadem1(IMPC)Mbp HOM   Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.


XRay Images Whole Body Dorso Ventral

93 Images


XRay Images Whole Body Lateral Orientation

31 Images

Gross Morphology Embryo E9.5


4 Images

Human diseases caused by Cad mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Cad by orthology or direct annotation.

Disease Similarity of
Matching phenotypes Source
Developmental And Epileptic Encephalopathy 50

The table below shows human diseases predicted to be associated to Cad by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Developmental And Epileptic Encephalopathy 50


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cad

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cad.

There are 10 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Trans-homophilic interaction of CADM1 promotes organ infiltration of T-cell lymphoma by adhesion to vascular endothelium. Cancer science (March 2022) Cadm1tm1a(EUCOMM)Wtsi PMC9128163
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Cadm1tm1.2Brd PMC7263671
The Synaptic Vesicle Priming Protein CAPS-1 Shapes the Adaptation of Sensory Evoked Responses in Mouse Visual Cortex. Cell reports (March 2020) Cadpstm1c(EUCOMM)Hmgu Cadpstm1a(EUCOMM)Hmgu 32160535
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Cadm1tm1.2Brd Cadm1tm1.2Brd Cadm1tm1a(EUCOMM)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Cadm1tm1a(EUCOMM)Wtsi Cadm1tm1.2Brd PMC6459510
Adipocyte Xbp1s overexpression drives uridine production and reduces obesity. Molecular metabolism (March 2018) Cadtm1a(KOMP)Wtsi PMC6001360
Cadm2 regulates body weight and energy homeostasis in mice. Molecular metabolism (November 2017) Cadm2tm1a(KOMP)Mbp PMC5985021
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Cadm1tm1.2Brd PMC5827107
Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1. Nature neuroscience (June 2017) Cadm2tm1a(KOMP)Mbp PMC5533218
Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength. PLoS genetics (August 2012) Cadm1tm1a(EUCOMM)Wtsi PMC3410859

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Cadtm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Cadem1(IMPC)Mbp Exon Deletion Mice, Tissue
Cadtm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells

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