Gene Summary

Name:
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Synonyms:
2410008J01Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
limb grasping Cadem1(IMPC)Mbp HET   Early adult 3.83×10-05
preweaning lethality, complete penetrance Cadem1(IMPC)Mbp HOM   Early adult 0.00
decreased prepulse inhibition Cadem1(IMPC)Mbp HET Early adult 1.75×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

51 Images

X-ray

XRay Images Whole Body Lateral Orientation

17 Images

Human diseases caused by Cad mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Cad by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Developmental And Epileptic Encephalopathy 50
OMIM:616457

The table below shows human diseases predicted to be associated to Cad by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Developmental And Epileptic Encephalopathy 50
OMIM:616457

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cad

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cad.

There are 9 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Cadm1tm1.2Brd PMC7263671
The Synaptic Vesicle Priming Protein CAPS-1 Shapes the Adaptation of Sensory Evoked Responses in Mouse Visual Cortex. Cell reports (March 2020) Cadpstm1c(EUCOMM)Hmgu Cadpstm1a(EUCOMM)Hmgu 32160535
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Cadm1tm1.2Brd Cadm1tm1.2Brd Cadm1tm1a(EUCOMM)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Cadm1tm1a(EUCOMM)Wtsi Cadm1tm1.2Brd PMC6459510
Adipocyte Xbp1s overexpression drives uridine production and reduces obesity. Molecular metabolism (March 2018) Cadtm1a(KOMP)Wtsi PMC6001360
Cadm2 regulates body weight and energy homeostasis in mice. Molecular metabolism (November 2017) Cadm2tm1a(KOMP)Mbp PMC5985021
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Cadm1tm1.2Brd PMC5827107
Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1. Nature neuroscience (June 2017) Cadm2tm1a(KOMP)Mbp PMC5533218
Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength. PLoS genetics (August 2012) Cadm1tm1a(EUCOMM)Wtsi PMC3410859

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MGI Allele Allele Type Produced
Cadem1(IMPC)Mbp Exon Deletion Mice, Tissue
Cadtm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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