Gene: Exosc8

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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Exosc8tm1.1(KOMP)Vlcg HOM Early adult 0.00
embryonic lethality prior to organogenesis Exosc8tm1.1(KOMP)Vlcg HOM E9.5 0.00
embryonic lethality prior to tooth bud stage Exosc8tm1.1(KOMP)Vlcg HOM E12.5 0.00

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2) N/A
Aorta 2 No  (2/2) N/A
Bone 2 No  (2/2) N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No  (2/2) N/A
Brown adipose tissue 2 No  (2/2) N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No  (2/2) N/A
Cerebral cortex 2 No  (2/2) N/A
Epididymis 2 No  (18/134) N/A
Esophagus 2 No  (7/415)  (2/2) N/A
Eye 2 No  (2/2) N/A
Heart 2 No  (2/2) N/A
Hippocampus 2 No  (2/2) N/A
Hypothalamus 2 No  (2/2) N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584)  (2/2) N/A
Liver 2 No  (2/2) N/A
Lower urinary tract 2 No N/A
Lung 2 No  (2/2) N/A
Lymph node 2 No  (2/2) N/A
Mammary gland 2 No  (1/2) N/A
Midbrain 2 No  (2/2) N/A
Olfactory lobe 2 No  (2/2) N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584)  (2/2) N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (2/2) N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2) N/A
Small intestine 2 No  (9/584)  (2/2) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584)  (2/2) N/A
Stomach 2 No  (12/584)  (2/2) N/A
Striatum 2 No  (2/2) N/A
Submandibular gland 2 No  (2/132)  (2/2) N/A
Testis 2 No  (2/584)  (1/2) N/A
Thalamus 2 No  (2/2) N/A
Thymus 2 No  (2/2) N/A
Thyroid gland 2 No  (15/584)  (2/2) N/A
Trachea 2 No  (2/2) N/A
Urinary bladder 2 No  (2/2) N/A
Uterus 2 No  (1/2) N/A
Vascular system 2 No N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No  (2/2) N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 1  (1/61)  (1/1) N/A
Brain 1  (6/504)  (1/1) N/A
Ear 1  (1/504)  (1/1) N/A
Embryo 1  (1/505)  (1/1)  Wholemount images
Eye 1  (1/504) N/A
Foot 1  (1/504)  (1/1) N/A
Forebrain 1  (1/504)  (1/1) N/A
Forelimb 1  (1/504)  (1/1) N/A
Hand 1  (1/503)  (1/1) N/A
Head 1  (5/504)  (1/1) N/A
Heart 1  (1/504)  (1/1) N/A
Hindbrain 1  (6/504)  (1/1) N/A
Hindlimb 1  (1/503)  (1/1) N/A
Liver 1  (1/504)  (1/1) N/A
Lung 1  (1/500) N/A
Mandibular process 1  (1/504)  (1/1) N/A
Maxillary process 1  (1/504)  (1/1) N/A
Midbrain 1  (1/504)  (1/1) N/A
Nose 1  (1/70)  (1/1) N/A
Oral cavity 1  (1/504)  (1/1) N/A
Skeleton 1  (1/70)  (1/1) N/A
Skin 1  (1/504)  (1/1) N/A
Tail 1  (1/504)  (1/1) N/A
Tail somite 1  (1/504) N/A
Umbilical artery embryonic part 1  (1/57)  (1/1) N/A
Umbilical vein embryonic part 1  (1/57)  (1/1) N/A

 Associated Images

X-ray: XRay Images Forepaw
9 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
9 Images
X-ray: XRay Images Skull Lateral Orientation
9 Images
X-ray: XRay Images Whole Body Dorso Ventral
9 Images
X-ray: XRay Images Whole Body Lateral Orientation
9 Images
Eye Morphology: Images Ophthalmoscopy
1 Images
Embryo LacZ: LacZ images wholemount
8 Images
Sleep Wake: Wake state (bmp file)
3 Images
Electroretinography: Rod waveform (pdf format)
3 Images
Electroretinography: Cone waveform (pdf format)
3 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Exosc8tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice
Exosc8tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells
Exosc8tm47080(L1L2_gt0) Targeting vectors
Exosc8tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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