Gene: Arhgef12

Name
Rho guanine nucleotide exchange factor (GEF) 12
MGI ID
MGI:1916882
Synonyms
LARG 2310014B11Rik
Viability
Homozygous - Subviable
Other links
View data by physiological system
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, incomplete penetrance Arhgef12tm1b(KOMP)Wtsi HOM n/a 0.00
prenatal lethality prior to heart atrial septation Arhgef12tm1b(KOMP)Wtsi HOM embryonic day 14.5 0.00
abnormal sensory capabilities/reflexes/nociception Arhgef12tm1b(KOMP)Wtsi HET postnatal 5.27×10-09
abnormal embryo size Arhgef12tm1b(KOMP)Wtsi HET embryonic day 9.5 0.00
embryonic growth retardation Arhgef12tm1b(KOMP)Wtsi HOM embryonic day 9.5 0.00
embryonic growth retardation Arhgef12tm1b(KOMP)Wtsi HET embryonic day 9.5 0.00
decreased circulating insulin level Arhgef12tm1b(KOMP)Wtsi HET postnatal 5.26×10-05
abnormal embryo size Arhgef12tm1b(KOMP)Wtsi HOM embryonic day 9.5 0.00

Download data as:  TSV  XLS

Filtered by: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2) N/A
Aorta 2 No  (2/2) N/A
Blood 2 No  (1/2) N/A
Bone marrow 2 No N/A
Brain 2 No N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No  (2/2) N/A
Cartilage tissue 2 No N/A
Cecum 2 No  (12/383)  (2/2) N/A
Cerebellum 2 No  (2/2) N/A
Cerebral cortex 2 No N/A
Chest bone 2 No N/A
Colon 2 No  (12/127)  (2/2) N/A
Diaphragm 2 No  (1/2) N/A
Duodenum 2 No  (2/127)  (2/2) N/A
Epididymis 2 No  (18/134)  (1/2) N/A
Esophagus 2 No  (7/415)  (2/2) N/A
Eye 2 No  (2/2) N/A
Gall bladder 2 No N/A
Gonadal fat pad 2 No  (2/2) N/A
Harderian gland 2 No  (2/2) N/A
Heart 2 No N/A
Hindlimb 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Ileum 2 No  (14/127)  (2/2) N/A
Jejunum 2 No  (6/127)  (2/2) N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No  (1/2) N/A
Lower urinary tract 2 No N/A
Lung 2 No  (2/2) N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Mesenteric adipose tissue 2 No  (1/2) N/A
Mesenteric lymph node 2 No N/A
Midbrain 2 No  (2/2) N/A
Olfactory lobe 2 No  (1/2) N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584)  (2/2) N/A
Parathyroid gland 2 No N/A
Parotid gland 2 No  (2/2) N/A
Penis 2 No  (1/2) N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/2) N/A
Prostate gland 2 No  (12/584)  (1/2) N/A
Quadriceps 2 No  (1/2) N/A
Sciatic nerve 2 No N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2) N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584)  (2/2) N/A
Stomach 2 No  (12/584)  (2/2) N/A
Stomach pyloric region 2 No N/A
Striatum 2 No N/A
Sublingual gland 2 No  (2/2) N/A
Submandibular gland 2 No  (2/132)  (2/2) N/A
Testis 2 No  (2/584)  (1/2) N/A
Thymus 2 No  (2/2) N/A
Thyroid gland 2 No  (15/584)  (1/2) N/A
Tongue 2 No  (5/127)  (1/2) N/A
Trachea 2 No  (1/2) N/A
Trigeminal V nerve 2 No  (2/2) N/A
Urinary bladder 2 No  (2/2) N/A
Uterus 2 No  (1/2) N/A
Vagina 2 No  (1/2) N/A
Vas deferens 2 No  (15/388)  (1/2) N/A
Vascular system 2 No N/A
Vesicular gland 2 No  (1/2) N/A
White adipose tissue 2 No N/A
No Embryo expression data was found for this gene.

 Associated Images

X-ray: XRay Images Dorso Ventral
10 Images
X-ray: XRay Images Lateral Orientation
10 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Arhgef12tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Arhgef12tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue

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