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Genes Phenotypes Help, News, Blog

Gene: Kansl2 MGI:1916862

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
KAT8 regulatory NSL complex subunit 2
Synonyms:
2310037I24Rik

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Kansl2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Kansl2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Kansl2.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature. Nature cell biology (June 2020) Kansl2tm1c(EUCOMM)Wtsi Kansl2tm1a(EUCOMM)Wtsi 32541879
Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate. Science advances (May 2020) Kansl2tm1a(EUCOMM)Wtsi PMC7314555
Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation. Nature communications (May 2020) Kansl2tm1a(EUCOMM)Wtsi PMC7206058

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MGI Allele Allele Type Produced
Kansl2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Kansl2tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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