Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
increased circulating alanine transaminase level | Ctdspltm1.1(KOMP)Mbp | HOM | Early adult | 8.60×10-06 | ||
increased circulating aspartate transaminase level | Ctdspltm1.1(KOMP)Mbp | HOM | Early adult | 2.56×10-08 | ||
impaired glucose tolerance | Ctdspltm1.1(KOMP)Mbp | HOM | Early adult | 3.05×10-05 | ||
decreased circulating total protein level | Ctdspltm1.1(KOMP)Mbp | HOM | Early adult | 3.75×10-05 | ||
decreased circulating serum albumin level | Ctdspltm1.1(KOMP)Mbp | HOM | Early adult | 1.48×10-05 |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Adrenal gland | Wholemount images | heterozygote | 50% (2 of 4) |
Aorta | Wholemount images | heterozygote | 50% (2 of 4) |
Brain | Wholemount images | heterozygote | 100% (4 of 4) |
Cerebellum | Wholemount images | heterozygote | 50% (2 of 4) |
Chest bone | Wholemount images | heterozygote | 50% (2 of 4) |
Colon | Wholemount images Section images | heterozygote | 75% (3 of 4) |
Duodenum | Section images | heterozygote | 50% (2 of 4) |
Epididymis | Section images | heterozygote | 50% (2 of 4) |
Esophagus | Wholemount images | heterozygote | 50% (2 of 4) |
Eye | Wholemount images Section images | heterozygote | 75% (3 of 4) |
Gall bladder | Wholemount images | heterozygote | 50% (2 of 4) |
Gonadal fat pad | Wholemount images | heterozygote | 50% (2 of 4) |
Harderian gland | Wholemount images | heterozygote | 50% (2 of 4) |
Ileum | Section images | heterozygote | 100% (4 of 4) |
Kidney | Wholemount images Section images | heterozygote | 100% (4 of 4) |
Lung | Wholemount images | heterozygote | 50% (2 of 4) |
Mesenteric adipose tissue | Wholemount images | heterozygote | 50% (2 of 4) |
Midbrain | Wholemount images Section images | heterozygote | 100% (4 of 4) |
Olfactory lobe | Wholemount images Section images | heterozygote | 100% (4 of 4) |
Ovary | Wholemount images | heterozygote | 25% (1 of 4) |
Oviduct | Wholemount images | heterozygote | 25% (1 of 4) |
Pancreas | Wholemount images | heterozygote | 50% (2 of 4) |
Penis | Section images | heterozygote | 25% (1 of 4) |
Pituitary gland | Wholemount images | heterozygote | 50% (2 of 4) |
Prostate gland | Wholemount images | heterozygote | 25% (1 of 4) |
Sciatic nerve | Wholemount images | heterozygote | 50% (2 of 4) |
Skin | Wholemount images Section images | heterozygote | 100% (4 of 4) |
Spinal cord | Wholemount images | heterozygote | 50% (2 of 4) |
Spleen | Section images | heterozygote | 50% (2 of 4) |
Stomach | Wholemount images Section images | heterozygote | 75% (3 of 4) |
Sublingual gland | Section images | heterozygote | 25% (1 of 4) |
Submandibular gland | Section images | heterozygote | 50% (2 of 4) |
Testis | Wholemount images Section images | heterozygote | 50% (2 of 4) |
Thyroid gland | Wholemount images | heterozygote | 50% (2 of 4) |
Tongue | Wholemount images Section images | heterozygote | 75% (3 of 4) |
Trachea | Wholemount images Section images | heterozygote | 100% (4 of 4) |
Urinary bladder | Wholemount images | heterozygote | 50% (2 of 4) |
Uterus | Wholemount images Section images | heterozygote | 50% (2 of 4) |
Vagina | Section images | heterozygote | 25% (1 of 4) |
Vas deferens | Wholemount images Section images | heterozygote | 50% (2 of 4) |
Vesicular gland | Wholemount images Section images | heterozygote | 50% (2 of 4) |
Blood | N/A | heterozygote | 0.0% (0 of 4) |
Bone marrow | N/A | heterozygote | 0.0% (0 of 4) |
Brainstem | N/A | heterozygote | Not available |
Brown adipose tissue | N/A | heterozygote | 0.0% (0 of 4) |
Cartilage tissue | N/A | heterozygote | Not available |
Cecum | N/A | heterozygote | 50% (2 of 4) |
Cerebral cortex | N/A | heterozygote | Not available |
Diaphragm | N/A | heterozygote | 50% (2 of 4) |
Heart | N/A | heterozygote | Not available |
Hindlimb | N/A | heterozygote | Not available |
Hippocampus | N/A | heterozygote | Not available |
Hypothalamus | N/A | heterozygote | Not available |
Jejunum | N/A | heterozygote | 50% (2 of 4) |
Large intestine | N/A | heterozygote | 75% (3 of 4) |
Liver | N/A | heterozygote | 0.0% (0 of 4) |
Lower urinary tract | N/A | heterozygote | Not available |
Lymph node | N/A | heterozygote | Not available |
Mammary gland | N/A | heterozygote | 0.0% (0 of 4) |
Mesenteric lymph node | N/A | heterozygote | 0.0% (0 of 4) |
Parathyroid gland | N/A | heterozygote | 50% (2 of 4) |
Parotid gland | N/A | heterozygote | 0.0% (0 of 4) |
Peripheral nervous system | N/A | heterozygote | Not available |
Peyer's patch | N/A | heterozygote | Not available |
Quadriceps | N/A | heterozygote | 0.0% (0 of 4) |
Skeletal muscle | N/A | heterozygote | Not available |
Small intestine | N/A | heterozygote | 100% (4 of 4) |
Stomach pyloric region | N/A | heterozygote | Not available |
Striatum | N/A | heterozygote | Not available |
Thymus | N/A | heterozygote | 0.0% (0 of 4) |
Trigeminal V nerve | N/A | heterozygote | 0.0% (0 of 4) |
Vascular system | N/A | heterozygote | Not available |
White adipose tissue | N/A | heterozygote | Not available |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|---|
adrenal gland | 0.68% (4 of 586) |
aorta | 0.17% (1 of 594) |
blood | 0.0% |
bone marrow | 0.0% |
brain | 0.85% (5 of 586) |
brainstem | 0.34% (2 of 588) |
brown adipose tissue | 0.0% |
cartilage tissue | 0.17% (1 of 590) |
cecum | 5.63% (21 of 373) |
cerebellum | 0.51% (3 of 594) |
cerebral cortex | 0.34% (2 of 588) |
chest bone | Unavailable |
colon | 15.83% (22 of 139) |
diaphragm | 0.0% |
duodenum | 3.7% (5 of 135) |
epididymis | 13.79% (20 of 145) |
esophagus | 1.69% (7 of 415) |
eye | 0.0% |
gall bladder | 0.0% |
gonadal fat pad | 0.0% |
harderian gland | 0.71% (1 of 140) |
heart | 0.34% (2 of 588) |
hindlimb | 0.0% |
hippocampus | 0.34% (2 of 590) |
hypothalamus | 0.34% (2 of 592) |
ileum | 14.39% (20 of 139) |
jejunum | 8.7% (12 of 138) |
kidney | 4.55% (27 of 593) |
large intestine | 5.41% (32 of 592) |
liver | 0.0% |
lower urinary tract | 0.17% (1 of 586) |
lung | 0.34% (2 of 581) |
lymph node | 0.17% (1 of 585) |
mammary gland | 0.0% |
mesenteric adipose tissue | 0.0% |
mesenteric lymph node | 0.31% (1 of 321) |
midbrain | 0.0% |
olfactory lobe | 0.34% (2 of 587) |
ovary | 0.17% (1 of 586) |
oviduct | 0.0% |
pancreas | 0.85% (5 of 585) |
parathyroid gland | 0.18% (1 of 566) |
parotid gland | 0.0% |
penis | 0.0% |
peripheral nervous system | 0.34% (2 of 587) |
peyers patch | 0.0% |
pituitary gland | 0.17% (1 of 589) |
prostate gland | 2.04% (12 of 588) |
quadriceps | 0.0% |
sciatic nerve | 0.0% |
skeletal muscle | 0.0% |
skin | 0.17% (1 of 593) |
small intestine | 5.43% (32 of 589) |
spinal cord | 0.51% (3 of 587) |
spleen | 0.51% (3 of 590) |
stomach | 3.73% (22 of 590) |
stomach pyloric region | 0.0% |
striatum | 0.51% (3 of 583) |
sublingual gland | 0.0% |
submandibular gland | 1.4% (2 of 143) |
testis | 0.85% (5 of 591) |
thymus | 0.17% (1 of 590) |
thyroid gland | 2.89% (17 of 588) |
tongue | 3.62% (5 of 138) |
trachea | 0.51% (3 of 590) |
trigeminal v nerve | 0.0% |
urinary bladder | 0.0% |
uterus | 0.34% (2 of 590) |
vagina | 0.0% |
vas deferens | 4.65% (18 of 387) |
vascular system | 0.0% |
vesicular gland | 0.0% |
white adipose tissue | 0.0% |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Ctdspl by phenotypic similarity.
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MGI Allele | Allele Type | Produced |
---|---|---|
Ctdspltm1.1(KOMP)Mbp | Reporter-tagged deletion allele (post Cre, with no selection cassette) | Mice, Tissue |
Ctdspltm1(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | Mice, Targeting vectors, ES Cells |
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